Gerhard Schenkirsch
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View article: Bridging Data Silos in Oncology with Modular Software for Federated Analysis on Fast Healthcare Interoperability Resources: Multisite Implementation Study
Bridging Data Silos in Oncology with Modular Software for Federated Analysis on Fast Healthcare Interoperability Resources: Multisite Implementation Study Open
Background Real-world data (RWD) from sources like administrative claims, electronic health records, and cancer registries offer insights into patient populations beyond the tightly regulated environment of randomized controlled trials. To…
View article: Bridging Data Silos in Oncology with Modular Software for Federated Analysis on FHIR: A Multisite Implementation Study (Preprint)
Bridging Data Silos in Oncology with Modular Software for Federated Analysis on FHIR: A Multisite Implementation Study (Preprint) Open
BACKGROUND Real-world data (RWD) from sources like administrative claims, electronic health records, and cancer registries offer insights into patient populations beyond the tightly regulated environment of randomized controlled trials. T…
View article: The WERA cancer center matrix: Strategic management of patient access to precision oncology in a large and mostly rural area of Germany
The WERA cancer center matrix: Strategic management of patient access to precision oncology in a large and mostly rural area of Germany Open
The WERA matrix provided a transparent portfolio of postal code areas, which helped assessing the geographical impact of our PO program. We believe that its intuitive principle can easily be transferred to other cancer centers.
View article: The WERA Cancer Center Matrix: Strategic Management of Patient Access to Precision Oncology in a Large and Mostly Rural Area of Germany
The WERA Cancer Center Matrix: Strategic Management of Patient Access to Precision Oncology in a Large and Mostly Rural Area of Germany Open
Purpose Offering equal Patient Access to Precision Oncology (PO) is a major challenge of clinical oncologists and cancer center representatives. Here, we provide an easily transferable model adopted from strategic management science to ass…
View article: The Concept of Stroma AReactive Invasion Front Areas (SARIFA) as a New Prognostic Biomarker for Lipid-driven Cancers Holds True in Pancreatic Ductal Adenocarcinoma
The Concept of Stroma AReactive Invasion Front Areas (SARIFA) as a New Prognostic Biomarker for Lipid-driven Cancers Holds True in Pancreatic Ductal Adenocarcinoma Open
Background Pancreatic ductal adenocarcinoma (PDAC) is a ‘difficult-to-treat’ entity. To forecast its prognosis, we introduced a new biomarker, SARIFA (stroma areactive invasion front areas), which are an area at the tumour invasion front l…
View article: ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series
ALK, NUT, and TRK Do Not Play Relevant Roles in Gastric Cancer—Results of an Immunohistochemical Study in a Large Series Open
ALK, NUT, and TRK are rare molecular aberrations that are pathognomonic for specific rare tumors. In low frequencies, however, they are found in a wide range of other tumor entities. This study aimed to investigate the frequency, associati…
View article: Associations between Weather, Air Quality and Moderate Extreme Cancer-Related Mortality Events in Augsburg, Southern Germany
Associations between Weather, Air Quality and Moderate Extreme Cancer-Related Mortality Events in Augsburg, Southern Germany Open
While many authors have described the adverse health effects of poor air quality and meteorological extremes, there remain inconsistencies on a regional scale as well as uncertainty about the single and joint effects of atmospheric predict…
View article: A Mass Spectrometry Imaging Based Approach for Prognosis Prediction in UICC Stage I/II Colon Cancer
A Mass Spectrometry Imaging Based Approach for Prognosis Prediction in UICC Stage I/II Colon Cancer Open
Currently, pathological evaluation of stage I/II colon cancer, following the Union Internationale Contre Le Cancer (UICC) guidelines, is insufficient to identify patients that would benefit from adjuvant treatment. In our study, we analyze…
View article: Stroma AReactive Invasion Front Areas (SARIFA)—A New Easily to Determine Biomarker in Colon Cancer—Results of a Retrospective Study
Stroma AReactive Invasion Front Areas (SARIFA)—A New Easily to Determine Biomarker in Colon Cancer—Results of a Retrospective Study Open
Many studies have used histomorphological features to more precisely predict the prognosis of patients with colon cancer, focusing on tumor budding, poorly differentiated clusters, and the tumor–stroma ratio. Here, we introduce SARIFA: Str…
View article: Stroma <scp>A</scp>Reactive <scp>I</scp>nvasion <scp>F</scp>ront <scp>A</scp>reas (<scp>SARIFA</scp>) – a new prognostic biomarker in gastric cancer related to tumor‐promoting adipocytes
Stroma <span>A</span>Reactive <span>I</span>nvasion <span>F</span>ront <span>A</span>reas (<span>SARIFA</span>) – a new prognostic biomarker in gastric cancer related to tumor‐promoting adipocytes Open
Compared to other malignancies, there is a lack of easy‐to‐evaluate biomarkers for gastric cancer, which is associated with an adverse clinical outcome in many cases. Here, we present S troma AR eactive I nvasion F ront A reas (SARIFA) as …
View article: Comprehensive Immunohistochemical Study of the SWI/SNF Complex Expression Status in Gastric Cancer Reveals an Adverse Prognosis of SWI/SNF Deficiency in Genomically Stable Gastric Carcinomas
Comprehensive Immunohistochemical Study of the SWI/SNF Complex Expression Status in Gastric Cancer Reveals an Adverse Prognosis of SWI/SNF Deficiency in Genomically Stable Gastric Carcinomas Open
The SWI/SNF complex has important functions in the mobilization of nucleosomes and consequently influences gene expression. Numerous studies have demonstrated that mutations or deficiency of one or more subunits can have an oncogenic effec…
View article: A Retrospective 5-Year Single Center Study Highlighting the Risk of Cancer Predisposition in Adolescents and Young Adults
A Retrospective 5-Year Single Center Study Highlighting the Risk of Cancer Predisposition in Adolescents and Young Adults Open
The knowledge of inherited cancer susceptibility opens a new field of cancer medicine. We conducted a retrospective single-center cohort study. Data of AYA cancer patients registered between January 2014 and December 2018 were analyzed. Th…
View article: Ultrastaging Using Ex Vivo Sentinel Lymph Node Mapping and One-Step Nucleic Acid Amplification (OSNA) in Gastric Cancer: Experiences of a European Center
Ultrastaging Using Ex Vivo Sentinel Lymph Node Mapping and One-Step Nucleic Acid Amplification (OSNA) in Gastric Cancer: Experiences of a European Center Open
Background: In this study, the effectiveness of One-step nucleic acid amplification (OSNA) in combination with ex vivo SLN mapping is compared with conventional histology including immunohistochemistry. Methods: LNs were retrieved from gas…
View article: Deep Learning Prediction of Metastasis in Locally Advanced Colon Cancer Using Binary Histologic Tumor Images
Deep Learning Prediction of Metastasis in Locally Advanced Colon Cancer Using Binary Histologic Tumor Images Open
In this study, we developed the Binary ImaGe Colon Metastasis classifier (BIg-CoMet), a semi-guided approach for the stratification of colon cancer patients into two risk groups for the occurrence of distant metastasis, using an InceptionR…
View article: Interobserver Variability in the Assessment of Tumor Budding in pT 3/4 Colon Cancer: Improvement by Supporting Immunohistochemistry?
Interobserver Variability in the Assessment of Tumor Budding in pT 3/4 Colon Cancer: Improvement by Supporting Immunohistochemistry? Open
The prognostic significance of tumor budding in colon cancer is unequivocally documented, and the recommendations of the International Tumor Budding Consensus Conference (ITBCC) are currently the accepted basis for its assessment. Up to no…
View article: Trends in cancer incidence and survival in the Augsburg study region—results from the Augsburg cancer registry
Trends in cancer incidence and survival in the Augsburg study region—results from the Augsburg cancer registry Open
Objectives Knowledge about time trends of cancer incidence and cancer survival in a defined region is an essential prerequisite for the planning of regional healthcare infrastructure. The aim of the study was to provide population-based an…
View article: Impact of uPA/PAI-1 and disseminated cytokeratin-positive cells in breast cancer
Impact of uPA/PAI-1 and disseminated cytokeratin-positive cells in breast cancer Open
uPA and PAI-1 seem to influence the metastatic potential of dCK+ cells, which underlines its important role in tumor progression.
View article: Impact of Primary Tumor Localization on the Efficacy of Bevacizumab in Metastatic Colorectal Cancer
Impact of Primary Tumor Localization on the Efficacy of Bevacizumab in Metastatic Colorectal Cancer Open
Adding bevacizumab to chemotherapy in mCRC may be beneficial only in patients with left-sided primary tumor, while those with right-sided primary tumors may have no additional benefit from the addition of bevacizumab. This hypothesis-gener…
View article: The prognostic significance of lymph node size in node-positive colon cancer
The prognostic significance of lymph node size in node-positive colon cancer Open
Metastasised lymph nodes affect all size categories, and large lymph nodes are not always metastasised. The combination of enlarged lymph nodes and a small lymph node metastasis to lymph node size ratio (MSR) is associated with a better pr…
View article: Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study
Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study Open
Aims . The prognostic role of the proteases uPA and PAI-1, as well as tumor budding, in colon cancer, has been investigated previously. Methods . We provide 6-year follow-up data and results of the validation set. The initial test set and …
View article: Number of Intratumoral T Lymphocytes Is Associated With Lymph Node Size, Lymph Node Harvest, and Outcome in Node-Negative Colon Cancer
Number of Intratumoral T Lymphocytes Is Associated With Lymph Node Size, Lymph Node Harvest, and Outcome in Node-Negative Colon Cancer Open
ITL density is independently prognostic and associated with LN harvest and LN size. The immune response is very likely the true explanation for the known prognostic effect of the LN harvest in colon cancer.
View article: A new simple morphology‐based risk score is prognostic in stage I/II colon cancers
A new simple morphology‐based risk score is prognostic in stage I/II colon cancers Open
A portion of stage I/ II colon cancers (10–20%) exhibit an adverse clinical course. The administration of adjuvant chemotherapy is recommended only in certain high‐risk situations. However, these risk factors recently failed to predict ben…
View article: Circulating cytokeratin-positive cells and tumor budding in colorectal cancer
Circulating cytokeratin-positive cells and tumor budding in colorectal cancer Open
CK+ cells and showed neither prognostic significance nor an association with tumor budding. It is very likely that CK18-staining is not specific enough to identify the relevant cells.