Gerhard Wikström
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View article: Passive leg raise echocardiography improves non-invasive diagnosis of HFpEF: A prospective validation against invasive hemodynamics
Passive leg raise echocardiography improves non-invasive diagnosis of HFpEF: A prospective validation against invasive hemodynamics Open
Background/Introduction Heart failure with preserved ejection fraction (HFpEF) remains difficult to diagnose non-invasively. The Passive Leg Raise (PLR) test with echocardiography provides a rapid, simple non-invasive assessment of stroke …
View article: Clinical characteristics of patients with suspected and verified PE: A single-center prospective cohort study
Clinical characteristics of patients with suspected and verified PE: A single-center prospective cohort study Open
In this prospective cohort study, we included 196 patients presenting with dyspnea and suspected pulmonary embolism (PE) at the emergency department of Uppsala University Hospital, Sweden, between June 2019 and July 2022. All patients unde…
View article: Health care resource use, diagnostic delay and disease burden in transthyretin amyloid cardiomyopathy in Sweden
Health care resource use, diagnostic delay and disease burden in transthyretin amyloid cardiomyopathy in Sweden Open
Advanced ATTR-CM stages are associated with significant healthcare costs, as patients more often require resource-intensive inpatient care. The current diagnostic trajectory of ATTR-CM in this study was characterized by a diagnostic delay …
View article: Repetitive LevosimenDan infusions fOR patients with advanced chronic heart failure in the vulnerable post-discharge period: the multinational randomized LeoDOR trial
Repetitive LevosimenDan infusions fOR patients with advanced chronic heart failure in the vulnerable post-discharge period: the multinational randomized LeoDOR trial Open
Background Studies of the repetitive use of intravenous levosimendan suggested a beneficial effect in patients with advanced heart failure (HF). It was the aim of the LeoDOR trial to test the efficacy and safety of intermittent levosimenda…
View article: Outcome prediction by myocardial external efficiency from <sup>11</sup>C‐acetate positron emission tomography in cardiac amyloidosis
Outcome prediction by myocardial external efficiency from <sup>11</sup>C‐acetate positron emission tomography in cardiac amyloidosis Open
Aims This study aimed to study the prognostic value of myocardial oxygen consumption (MVO 2 ) and myocardial external efficiency (MEE) from 11 C‐acetate positron emission tomography (PET) in cardiac amyloidosis (CA) patients. Methods and r…
View article: Repetitive levosimendan infusions for patients with advanced chronic heart failure in the vulnerable post‐discharge period: The multinational randomized <scp>LeoDOR</scp> trial
Repetitive levosimendan infusions for patients with advanced chronic heart failure in the vulnerable post‐discharge period: The multinational randomized <span>LeoDOR</span> trial Open
Aim The LeoDOR trial explored the efficacy and safety of intermittent levosimendan therapy in the vulnerable phase following a hospitalization for acute heart failure (HF). Methods and results In this prospective multicentre, double‐blind,…
View article: Peripheral Vascular Ageing in Pulmonary Arterial Hypertension as Assessed by Common Carotid Artery Intima Thickness and Intima/Media Thickness Ratio: An Investigation Using Non-Invasive High-Resolution Ultrasound
Peripheral Vascular Ageing in Pulmonary Arterial Hypertension as Assessed by Common Carotid Artery Intima Thickness and Intima/Media Thickness Ratio: An Investigation Using Non-Invasive High-Resolution Ultrasound Open
Patients with PAH displayed signs of peripheral vascular remodelling, challenging the common opinion that vascular changes in PAH are restricted to the lung vasculature. Correlations with cardiopulmonary variables from RHC support peripher…
View article: Characteristics and management of very elderly patients with heart failure: a retrospective, population cohort study
Characteristics and management of very elderly patients with heart failure: a retrospective, population cohort study Open
Aims Unmet needs exist in the diagnosis and treatment of heart failure (HF) in the elderly population. Our aim was to analyse and compare data of diagnostics and management of very elderly patients (aged ≥85 years) compared with younger pa…
View article: MicroRNA in Extracellular Vesicles from Patients with Pulmonary Arterial Hypertension Alters Endothelial Angiogenic Response
MicroRNA in Extracellular Vesicles from Patients with Pulmonary Arterial Hypertension Alters Endothelial Angiogenic Response Open
Pulmonary arterial hypertension (PAH) is characterized by a progressive elevation of pulmonary pressure leading to right ventricular dysfunction and is associated with a poor prognosis. Patients with PAH have increased numbers of circulati…
View article: Platelet-leukocyte aggregate formation and inflammation in patients with pulmonary arterial hypertension and CTEPH
Platelet-leukocyte aggregate formation and inflammation in patients with pulmonary arterial hypertension and CTEPH Open
Pulmonary hypertension (PH) is defined by increased mean pulmonary artery pressure, and the clinical classification includes five etiologies, of which we investigated subgroup 1, pulmonary arterial hypertension (PAH) and subgroup 4, chroni…
View article: The retirement of Editor-in-Chief Arne Andersson, Upsala Journal of Medical Sciences 2006–2022: an amazing journey under Arne’s stewardship
The retirement of Editor-in-Chief Arne Andersson, Upsala Journal of Medical Sciences 2006–2022: an amazing journey under Arne’s stewardship Open
an amazing journey under Arne's stewardshipThe day we have dreaded for several years has finally come.Our Editor-in-Chief (EIC), Professor Arne Andersson, has decided to retire after serving that role since 2006.During those years, Upsala …
View article: Healthcare resource utilisation and costs associated with a heart failure diagnosis: a retrospective, population-based cohort study in Sweden
Healthcare resource utilisation and costs associated with a heart failure diagnosis: a retrospective, population-based cohort study in Sweden Open
Objectives To examine healthcare resource use (HRU) and costs among heart failure (HF) patients using population data from Sweden. Design Retrospective, non-interventional cohort study. Setting Two cohorts were identified from linked natio…
View article: Early risk prediction in idiopathic<i>versus</i>connective tissue disease-associated pulmonary arterial hypertension: call for a refined assessment
Early risk prediction in idiopathic<i>versus</i>connective tissue disease-associated pulmonary arterial hypertension: call for a refined assessment Open
Despite systematic screening and improved treatment strategies, the prognosis remains worse in patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) compared to patients with idiopathic/hereditary pul…
View article: Recurrent heart failure hospitalizations increase the risk of cardiovascular and all‐cause mortality in patients with heart failure in Sweden: a real‐world study
Recurrent heart failure hospitalizations increase the risk of cardiovascular and all‐cause mortality in patients with heart failure in Sweden: a real‐world study Open
Aims Heart failure (HF) is a leading cause of hospitalization and is associated with high morbidity and mortality. We examined the impact of recurrent HF hospitalizations (HFHs) on cardiovascular (CV) mortality among patients with HF in Sw…
View article: Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study
Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study Open
Dimethylarginines were associated to signs of adverse effects on arterial wall layer dimensions and cardiovascular risk factors in women with and without preeclampsia, during pregnancy and to their changes from pregnancy up to one-year pos…
View article: Levosimendan Efficacy and Safety: 20 years of SIMDAX in Clinical Use
Levosimendan Efficacy and Safety: 20 years of SIMDAX in Clinical Use Open
Levosimendan was first approved for clinic use in 2000, when authorisation was granted by Swedish regulatory authorities for the haemodynamic stabilisation of patients with acutely decompensated chronic heart failure. In the ensuing 20 yea…
View article: Levosimendan Efficacy and Safety: 20 Years of SIMDAX in Clinical Use
Levosimendan Efficacy and Safety: 20 Years of SIMDAX in Clinical Use Open
Levosimendan was first approved for clinical use in 2000, when authorization was granted by Swedish regulatory authorities for the hemodynamic stabilization of patients with acutely decompensated chronic heart failure (HF). In the ensuing …
View article: Risk stratification in chronic thromboembolic pulmonary hypertension predicts survival
Risk stratification in chronic thromboembolic pulmonary hypertension predicts survival Open
To investigate if the pulmonary arterial hypertension (PAH) risk assessment tool presented in the 2015 ESC/ERS guidelines is valid for patients with chronic thromboembolic pulmonary hypertension (CTEPH) when taking pulmonary endarterectomy…
View article: Chytrid fungus dynamics and infections associated with movement distances in a red‐listed amphibian
Chytrid fungus dynamics and infections associated with movement distances in a red‐listed amphibian Open
Amphibians are among the most threatened vertebrate taxa due to anthropogenic habitat change and emerging pathogens. The fungus Batrachochytrium dendrobatidis ( Bd ) may cause trade‐offs between the immune responses and other important fun…
View article: Effects of Serelaxin in Patients with Acute Heart Failure
Effects of Serelaxin in Patients with Acute Heart Failure Open
In this trial involving patients who were hospitalized for acute heart failure, an infusion of serelaxin did not result in a lower incidence of death from cardiovascular causes at 180 days or worsening heart failure at 5 days than placebo.…
View article: 37Diagnostic accuracy of [11C]PIB positron emission tomography for detection of cardiac amyloidosis
37Diagnostic accuracy of [11C]PIB positron emission tomography for detection of cardiac amyloidosis Open
Background: [11C]PIB positron emission tomography (PIB-PET) has shown promise as a specific and non-invasive method for the diagnosis of cardiac amyloidosis (CA).Objectives: This study evaluated the diagnostic accuracy of the method. Metho…
View article: <p>Epidemiology of heart failure and trends in diagnostic work-up: a retrospective, population-based cohort study in Sweden</p>
Epidemiology of heart failure and trends in diagnostic work-up: a retrospective, population-based cohort study in Sweden Open
The annual incidence rate of HF declined over time, while prevalence of HF has increased, suggesting that patients with HF were surviving longer over time. Our study confirms that previously reported epidemiological trends persist and rema…
View article: Repetitive levosimendan infusions for patients with advanced chronic heart failure in the vulnerable post‐discharge period
Repetitive levosimendan infusions for patients with advanced chronic heart failure in the vulnerable post‐discharge period Open
Hospitalization for acute heart failure (HF) is associated with a substantial morbidity burden and with associated healthcare costs and an increased mortality risk. However, few if any major medical innovations have been witnessed in this …
View article: Right ventricular involvement in transthyretin amyloidosis
Right ventricular involvement in transthyretin amyloidosis Open
RV involvement is common in cardiac ATTR patients. The present study also detected an RV apical sparing pattern in patients with ATTR cardiomyopathy, similar to what has previously been described for the left ventricle in these patients. T…
View article: Plasma l-arginine levels distinguish pulmonary arterial hypertension from left ventricular systolic dysfunction
Plasma l-arginine levels distinguish pulmonary arterial hypertension from left ventricular systolic dysfunction Open
Pulmonary arterial hypertension (PAH) is a life-threatening condition, characterized by an imbalance of vasoactive substances and remodeling of pulmonary vasculature. Nitric oxide, formed from L-arginine, is essential for homeostasis and s…