Gerit Moser
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Adaptive Neutrophil Phenotypes and Their Functions in the Maternal Immune Landscape 2674 Open
Description Successful early pregnancy depends on tightly regulated immune interactions at the feto-maternal interface to support the development of the semi-allogenic fetus. Neutrophils, key components of the innate immune system, play an…
View article: Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interface
Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interface Open
This study suggests that maternal platelet-derived factors affect the transcriptional profile of trophoblasts, including upregulation of LAIR2, which may be involved in fine-tuning the coagulation of maternal blood leaking from eroded deci…
View article: Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts
Fluid shear stress induces a shift from glycolytic to amino acid pathway in human trophoblasts Open
Background The human placenta, a tissue with a lifespan limited to the period of pregnancy, is exposed to varying shear rates by maternal blood perfusion depending on the stage of development. In this study, we aimed to investigate the eff…
Early human trophoblast development: from morphology to function Open
Human pregnancy depends on the proper development of the embryo prior to implantation and the implantation of the embryo into the uterine wall. During the pre-implantation phase, formation of the morula is followed by internalization of bl…
View article: (Dis)similarities between the Decidual and Tumor Microenvironment
(Dis)similarities between the Decidual and Tumor Microenvironment Open
Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast cells invade maternal tissues while being tolerated by the maternal immune system. Similarly, tumor cells can invade surrounding tissues and esc…
Early Human Trophoblast Development: From Morphology To Function Open
Human pregnancy depends on the proper development of the embryo prior to implantation and the implantation of the embryo into the uterine wall. During the preimplantation phase, formation of the morula is followed by internalization of bla…
View article: The fate of human SUSD2+ endometrial mesenchymal stem cells during decidualization
The fate of human SUSD2+ endometrial mesenchymal stem cells during decidualization Open
Regeneration of the endometrial stromal compartment in premenopausal women is likely maintained by the perivascular endometrial mesenchymal stem/stromal cells (eMSC) expressing sushi domain containing 2 (SUSD2). The fate of SUSD2+ eMSC dur…
Placental Endocrine Activity: Adaptation and Disruption of Maternal Glucose Metabolism in Pregnancy and the Influence of Fetal Sex Open
The placenta is an endocrine fetal organ, which secretes a plethora of steroid- and proteo-hormones, metabolic proteins, growth factors, and cytokines in order to adapt maternal physiology to pregnancy. Central to the growth of the fetus i…
Automated Quantitative Image Evaluation of Antigen Retrieval Methods for 17 Antibodies in Placentation and Implantation Diagnostic and Research Open
Immunostaining in clinical routine and research highly depends on standardized staining methods and quantitative image analyses. We qualitatively and quantitatively compared antigen retrieval methods (no pretreatment, pretreatment with pep…
Imaging Of A Three Dimensional Model System For Invasive Growth Of Trophoblasts Open
Introduction The details of the processes of human implantation and subsequent trophoblast invasion into maternal tissues still remain mostly unknown. Due to ethical reasons live-imaging of the process of blastocyst implantation in humans …
Maternal Platelets—Friend or Foe of the Human Placenta? Open
Human pregnancy relies on hemochorial placentation, including implantation of the blastocyst and deep invasion of fetal trophoblast cells into maternal uterine blood vessels, enabling direct contact of maternal blood with placental villi. …
Trophoblast retrieval and isolation from the cervix: origins of cervical trophoblasts and their potential value for risk assessment of ongoing pregnancies Open
TRIC could one day provide a method of risk assessment for maternal and fetal disease, and reveal molecular pathways disrupted during the first trimester in EVT cells associated with placental maldevelopment. As perinatal interventions eme…
Extravillous trophoblasts invade more than uterine arteries: evidence for the invasion of uterine veins Open
During the first trimester of pregnancy, extravillous trophoblasts (EVTs) invade into the decidual interstitium to the first third of the myometrium, thereby anchoring the placenta to the uterus. They also follow the endovascular and endog…