Florien Jenner
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View article: Editorial: Effect of mechanical loading on the tendon for tissue engineering approaches
Editorial: Effect of mechanical loading on the tendon for tissue engineering approaches Open
View article: Integrated tissue proteomics and lipidomics from ovine organs suggests novel functional implications for fatty acids and lipid mediators
Integrated tissue proteomics and lipidomics from ovine organs suggests novel functional implications for fatty acids and lipid mediators Open
Lipid mediators are potent biomolecules that may help to gain specific information about biological processes. However, due to incomplete functional annotations and hence interpretive challenges these molecules are hardly considered in mol…
View article: Ontogenetic stage and type of donor cells shape extracellular vesicles’ therapeutic potential for osteoarthritis
Ontogenetic stage and type of donor cells shape extracellular vesicles’ therapeutic potential for osteoarthritis Open
Background Osteoarthritis (OA) remains an intractable condition due to the limited regenerative capacity of adult cartilage. Extracellular vesicles (EVs) have emerged as promising therapeutics, yet the optimal donor cell source is still un…
View article: An Animal‐Free Patient‐Derived Tissue‐Mimetic Biochip Model of the Human Synovial Membrane for Human‐Relevant Osteoarthritis Research
An Animal‐Free Patient‐Derived Tissue‐Mimetic Biochip Model of the Human Synovial Membrane for Human‐Relevant Osteoarthritis Research Open
Current synovial models fail to capture human‐relevant OA traits. This study develops a fully humanized, animal‐free synovial membrane model, mimicking OA synovial structure and molecular profile. Protocols for rheumatoid synovial micromas…
View article: Indicators of mortality risk in ageing horses
Indicators of mortality risk in ageing horses Open
Clinical care for patients with limited life expectancy often requires adjustments, prioritizing immediate benefits over long-term outcomes, as the relevance of future complications diminishes. This study identifies indicators of mortality…
View article: Beyond symptomatic alignment: evaluating the integration of causal mechanisms in matching animal models with human pathotypes in osteoarthritis research
Beyond symptomatic alignment: evaluating the integration of causal mechanisms in matching animal models with human pathotypes in osteoarthritis research Open
Osteoarthritis (OA) is a highly prevalent and disabling condition lacking curative treatments, with only symptomatic relief available. Recognizing OA as a heterogenous disorder with diverse aetiologies and molecular foundations underscores…
View article: Dexamethasone: a double-edged sword in the treatment of osteoarthritis
Dexamethasone: a double-edged sword in the treatment of osteoarthritis Open
Glucocorticoids are widely used to manage osteoarthritis (OA) symptoms, but long-term safety concerns exist. This study investigates the therapeutic potential of dexamethasone (DEX) and triamcinolone acetonide (TA) in chondrocytes, evaluat…
View article: Intracellular ROS Assay v1
Intracellular ROS Assay v1 Open
Accumulation of reactive oxygen species (ROS) coupled with an increase in oxidative stress has beenimplicated in the pathogenesis of several disease states. The role of oxidative stress in senescence is well established. Free radicals and …
View article: Caspase 3/7 Activity v1
Caspase 3/7 Activity v1 Open
The Caspase-Glo 3/7 Assay is a homogeneous, luminescent assay that measures caspase-3 and -7 activities. The assay provides a luminogenic caspase-3/7 substrate, which contains the tetrapeptide sequence DEVD, in a reagent optimized for casp…
View article: Immunofluorescence staining v1
Immunofluorescence staining v1 Open
H3K9me3/S10p (R20236, nsJ Bioreagents, San Diego, USA) isan epigenetic modification to the DNA packaging proteinHistone H3 involved in regulation of senescence. H3K9me3/S10p was detected by immunofluorescence assays.
View article: The role of space availability and affiliation in shaping equine social distances and dynamics
The role of space availability and affiliation in shaping equine social distances and dynamics Open
View article: The effect of cyclic fluid perfusion on the proinflammatory tissue environment in osteoarthritis using equine joint-on-a-chip models
The effect of cyclic fluid perfusion on the proinflammatory tissue environment in osteoarthritis using equine joint-on-a-chip models Open
This joint on a chip model, integrating inflammatory stimuli and cyclic fluid flow, allows for the study of OA pathogenesis in healthy and diseased states, offering critical insights into pathological tissue crosstalk.
View article: Correction: The effect of cyclic fluid perfusion on the proinflammatory tissue environment in osteoarthritis using equine joint-on-a-chip models
Correction: The effect of cyclic fluid perfusion on the proinflammatory tissue environment in osteoarthritis using equine joint-on-a-chip models Open
Correction for ‘The effect of cyclic fluid perfusion on the proinflammatory tissue environment in osteoarthritis using equine joint-on-a-chip models’ by Johannes Heidenberger et al. , Lab Chip , 2025, 25 , 2256–2269, https://doi.org/10.103…
View article: The modulating role of uniaxial straining in the IL-1β and TGF-β mediated inflammatory response of human primary ligamentocytes
The modulating role of uniaxial straining in the IL-1β and TGF-β mediated inflammatory response of human primary ligamentocytes Open
Biomechanical (over-)stimulation, in addition to inflammatory and fibrotic stimuli, severely impacts the anterior cruciate ligament (ACL) biology, contributing to the overall chronic nature of desmopathy. A major challenge has been the lac…
View article: RT-qPCR v1
RT-qPCR v1 Open
Gene expression levels by RT-qPCR
View article: SA-B-Gal Activity v1
SA-B-Gal Activity v1 Open
To measure cellular senescence
View article: Western Blot v1
Western Blot v1 Open
Western Blot - protein expression assessment
View article: “How long is life worth living for the horse?” A focus group study on how Austrian equine stakeholders assess quality of life for chronically ill or old horses
“How long is life worth living for the horse?” A focus group study on how Austrian equine stakeholders assess quality of life for chronically ill or old horses Open
View article: Time budgets and weight shifting as indicators of pain in hospitalized horses
Time budgets and weight shifting as indicators of pain in hospitalized horses Open
Introduction Pain assessment in horses presents a significant challenge due to their nonverbal nature and their tendency to conceal signs of discomfort in the presence of potential threats, including humans. Therefore, this study aimed to …
View article: Comparative proteomic profiling of the ovine and human PBMC inflammatory response
Comparative proteomic profiling of the ovine and human PBMC inflammatory response Open
View article: Proximity tracking using ultra-wideband technology for equine social behaviour research
Proximity tracking using ultra-wideband technology for equine social behaviour research Open
Sociopositive interactions with conspecifics are essential for equine welfare and quality of life. This study aimed to validate the use of wearable ultra-wideband (UWB) technology to quantify the spatial relationships and dynamics of socia…
View article: Video Ethogram of Equine Social Behaviour
Video Ethogram of Equine Social Behaviour Open
Equine social behaviour studies face challenges stemming from the absence of a comprehensive ethogram with unequivocal standardised definitions and the resulting limits to data comparison across studies. To address these constraints, this …
View article: The impact of opioid administration on the incidence of postanaesthetic colic in horses
The impact of opioid administration on the incidence of postanaesthetic colic in horses Open
Effective management of postoperative pain is essential to ensure patient welfare, reduce morbidity and optimize recovery. Opioids are effective in managing moderate to severe pain in horses but concerns over their adverse effects on gastr…
View article: Development, refinement, and validation of an equine musculoskeletal pain scale
Development, refinement, and validation of an equine musculoskeletal pain scale Open
Musculoskeletal disease is a common cause of chronic pain that is often overlooked and inadequately treated, impacting the quality of life of humans and horses alike. Lameness due to musculoskeletal pain is prevalent in horses, but the per…
View article: Mesenchymal Stem Cell Conditioned Medium Modulates Inflammation in Tenocytes: Complete Conditioned Medium Has Superior Therapeutic Efficacy than Its Extracellular Vesicle Fraction
Mesenchymal Stem Cell Conditioned Medium Modulates Inflammation in Tenocytes: Complete Conditioned Medium Has Superior Therapeutic Efficacy than Its Extracellular Vesicle Fraction Open
Tendinopathy, a prevalent overuse injury, lacks effective treatment options, leading to a significant impact on quality of life and socioeconomic burden. Mesenchymal stem/stromal cells (MSCs) and their secretome, including conditioned medi…
View article: Between Leisure and Pressure—Veterinarians’ Attitudes towards the Care of Competition Horses in Germany, Austria and Switzerland
Between Leisure and Pressure—Veterinarians’ Attitudes towards the Care of Competition Horses in Germany, Austria and Switzerland Open
Equine veterinarians face a range of challenges when attending competition horses. Athletic goals may significantly impact veterinary decision making, and the veterinarian’s work can be complicated by reputational considerations and rival …
View article: Equine Social Behaviour: Love, War and Tolerance
Equine Social Behaviour: Love, War and Tolerance Open
Sociality is an ethological need of horses that remained unchanged by domestication. Accordingly, it is essential to include horses’ social behavioural requirements and the opportunity to establish stable affiliative bonds in equine manage…
View article: Immortalized murine tenocyte cells: a novel and innovative tool for tendon research
Immortalized murine tenocyte cells: a novel and innovative tool for tendon research Open
View article: Immortalized murine tenocyte cells – a novel and innovative tool for tendon research
Immortalized murine tenocyte cells – a novel and innovative tool for tendon research Open
Primary tenocytes rapidly undergo senescence and a phenotypic drift upon in vitro monolayer culture, which limits tendon research. The Ink4a/Arf locus encodes the proteins p16Ink4a/Arf and p14ARF (p19ARF in mice) that regulate cell cycle p…
View article: Tendinopathy: sex bias starts from the preclinical development of tendon treatments. A systematic review
Tendinopathy: sex bias starts from the preclinical development of tendon treatments. A systematic review Open