Explanipedia

miR-210 promotes the anti-inflammatory phenotype and M2 polarization in murine macrophages Open

Carmen Alexandra Neculachi, Evelyn-Gabriela Nastase-Rusu, Laura Cherry, Catalina Iolanda Marinescu-Colan, Spyros Tastsoglou , et al. · 2025

Introduction Macrophages play fundamental roles in immune regulation and tissue homeostasis, serving as one of the primary cell types that orchestrate tissue repair after injury. MiR-210 is a hypoxia-inducible, small non-coding RNA involve…

Comparing venous wall effects using the empty vein ablation technique with VELEX catheter, endovenous laser ablation and foam sclerotherapy in an animal model Open

Mario Salerno, Daniele Bissacco, Yung‐Wei Chi, Sryram Narayanan, A. Addis , et al. · 2025

This study provides crucial insights into the effectiveness of different vein treatment techniques, particularly the empty vein ablation method, in minimizing residual intima and media thickness. By evaluating these outcomes in a sheep mod…

Circular PVT1 promotes cardiac fibroblast activation interacting with miR-30a-5p and miR-125b-5p Open

Alessia Bibi, Alisia Madè, Simona Greco, José Manuel García-Manteiga, Anna Sofia Tascini , et al. · 2025

Muscle‐specific gene editing improves molecular and phenotypic defects in a mouse model of myotonic dystrophy type 1 Open

Mariapaola Izzo, Jonathan Battistini, Elisabetta Golini, Christine Voellenkle, Claudia Provenzano , et al. · 2025

Background Myotonic dystrophy type 1 (DM1) is a genetic multisystemic disease, characterised by pleiotropic symptoms that exhibit notable variability in severity, nature and age of onset. The genetic cause of DM1 is the expansion of unstab…

miR-210 overexpression increases pressure overload-induced cardiac fibrosis Open

Germana Zaccagnini, Denisa Baci, Spyros Tastsoglou, Izabela Campos Cozza, Alisia Madè , et al. · 2025

Aortic stenosis, a common valvular heart disease, can lead to left ventricular pressure overload, triggering pro-fibrotic responses in the heart. miR-210 is a microRNA that responds to hypoxia and ischemia and plays a role in immune regula…

miR‐210 as a therapeutic target in diabetes‐associated endothelial dysfunction Open

Aida Collado, Tong Jiao, Eftychia Kontidou, Lucas Rannier Ribeiro Antonino Carvalho, Ekaterina Chernogubova , et al. · 2024

Background and Purpose MicroRNA (miR)‐210 function in endothelial cells and its role in diabetes‐associated endothelial dysfunction are not fully understood. We aimed to characterize the miR‐210 function in endothelial cells and study its …

miR-210 is essential to retinal homeostasis in fruit flies and mice Open

Davide Colaianni, Federico Virga, Annamaria Tisi, Chiara Stefanelli, Germana Zaccagnini , et al. · 2024

Circular PVT1 promotes cardiac fibroblast activation via sponging miR-30a-5p and miR-125b-5p Open

Fabio Martelli, Alessia Bibi, Alisia Madè, Simona Greco, Jose Garcia Manteiga , et al. · 2024

Circular RNAs (circRNAs) are involved in the pathogenesis of several cardiovascular diseases, including heart failure. In this study, we report that circular PVT1 (circPVT1) was upregulated in the left ventricle of 31 ischemic heart failur…

miR-210 is essential to retinal homeostasis in fruit flies and mice Open

Davide Colaianni, Federico Virga, Annamaria Tisi, Chiara Stefanelli, Germana Zaccagnini , et al. · 2024

Summary miR-210 is one of the most evolutionarily conserved microRNAs. Recent studies in Drosophila melanogaster have unveiled that the absence of miR-210 leads to a progressive retinal degeneration characterized by the accumulation of lip…

Interleukin 11-induced microRNAs as functional mediators and circulating biomarkers of cardiac fibrosis Open

Roman Tikhomirov, Benedict Reilly-O’Donnell, Carla Lucarelli, Prashant K. Srivastava, Maryam Anwar , et al. · 2023

Background Cardiac fibrosis can be triggered by several pathologies, including ischemic heart disease and aortic stenosis (AS). Cardiac fibrosis is brought about by uncontrolled extracellular matrix (ECM) deposition by myofibroblasts. Inte…

Dataset related to the article "Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation" Open

Gloria Garoffolo, Casaburo Manuel, Amadeo Francesco, Massimo Salvi, Giacomo Bernava , et al. · 2023

This record contains raw data related to the article "Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation". Abstract Background: Conversion of cardiac stromal cells into myofibroblasts is typic…

Dataset related to the article "Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation" Open

Gloria Garoffolo, Casaburo Manuel, Amadeo Francesco, Massimo Salvi, Giacomo Bernava , et al. · 2023

This record contains raw data related to the article "Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation". Abstract Background: Conversion of cardiac stromal cells into myofibroblasts is typic…

Reduction of Cardiac Fibrosis by Interference With YAP-Dependent Transactivation Open

Gloria Garoffolo, Manuel Casaburo, Francesco Amadeo, Massimo Salvi, Giacomo Bernava , et al. · 2022

Background: Conversion of cardiac stromal cells into myofibroblasts is typically associated with hypoxia conditions, metabolic insults, and/or inflammation, all of which are predisposing factors to cardiac fibrosis and heart failure. We hy…

Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia. Open

Germana Zaccagnini, Simona Greco, M Longo, Biagina Maimone, Christine Voellenkle , et al. · 2022

Zaccagnini G, Greco S, Longo M, Maimone B, Voellenkle C, Fuschi P, Carrara M, Creo P, Maselli D, Tirone M, Mazzone M, Gaetano C, Spinetti G, Martelli F. Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute is…

Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia. Open

Germana Zaccagnini, Simona Greco, M Longo, Biagina Maimone, Christine Voellenkle , et al. · 2022

Zaccagnini G, Greco S, Longo M, Maimone B, Voellenkle C, Fuschi P, Carrara M, Creo P, Maselli D, Tirone M, Mazzone M, Gaetano C, Spinetti G, Martelli F. Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute is…

Correction: Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia Open

Germana Zaccagnini, Simona Greco, M Longo, Biagina Maimone, Christine Voellenkle , et al. · 2021

Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia Open

Germana Zaccagnini, Simona Greco, M Longo, Biagina Maimone, Christine Voellenkle , et al. · 2021

Hypoxia-induced miR-210 is a crucial component of the tissue response to ischemia, stimulating angiogenesis and improving tissue regeneration. Previous analysis of miR-210 impact on the transcriptome in a mouse model of hindlimb ischemia s…

Hypoxia-induced miR-210 modulates inflammatory response and fibrosis upon acute peripheral ischemia Open

Germana Zaccagnini, Simona Greco, M Longo, Biagina Maimone, Christine Voellenkle , et al. · 2020

Introduction We previously demonstrated in mouse models of peripheral and heart ischemia that miR-210 is necessary and sufficient to stimulate blood perfusion recovery, as well as arteriolar and capillary density increase following ischemi…

Hypoxia-Induced miR-210 Is Necessary for Vascular Regeneration upon Acute Limb Ischemia Open

Germana Zaccagnini, Biagina Maimone, Paola Fuschi, M Longo, Daniel Da Silva , et al. · 2019

Critical limb ischemia is the most serious form of peripheral artery disease, characterized by severe functional consequences, difficult clinical management and reduced life expectancy. The goal of this study was to investigate the miR-210…

P300/CBP‐associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation Open

Matteo Savoia, Chiara Cencioni, Mattia Mori, Sandra Atlante, Germana Zaccagnini , et al. · 2018

The epigenetic enzyme p300/CBP‐associated factor (PCAF) belongs to the GCN5‐related N ‐acetyltransferase (GNAT) family together with GCN5. Although its transcriptional and post‐translational function is well characterized, little is known …

miR-210 Enhances the Therapeutic Potential of Bone-Marrow-Derived Circulating Proangiogenic Cells in the Setting of Limb Ischemia Open

Marie Besnier, Stefano Gasparino, Rosa Vono, Elena Sangalli, Amanda Facoetti , et al. · 2018

Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients Open

Francesco Spallotta, Chiara Cencioni, Sandra Atlante, Davide Garella, Mattia Cocco , et al. · 2017

Rationale: Human cardiac mesenchymal cells (CMSCs) are a therapeutically relevant primary cell population. Diabetes mellitus compromises CMSC function as consequence of metabolic alterations and incorporation of stable epigenetic changes. …

Overexpression of miR-210 and its significance in ischemic tissue damage Open

Germana Zaccagnini, Biagina Maimone, Paola Fuschi, Davide Maselli, Gaia Spinetti , et al. · 2017

Increased BACE1-AS long noncoding RNA and β-amyloid levels in heart failure Open

Simona Greco, Germana Zaccagnini, Paola Fuschi, Christine Voellenkle, Matteo Carrara , et al. · 2017

Given the neurotoxic role of β-amyloid in AD, dysregulation of the BACE1/BACE1-AS/β-amyloid axis might be relevant in HF pathogenesis, further implicating ncRNAs in the complex scenario of proteotoxicity in cardiac dysfunction.

Long noncoding RNA dysregulation in ischemic heart failure Open

Simona Greco, Germana Zaccagnini, Alessandra Perfetti, Paola Fuschi, Rea Valaperta , et al. · 2016

microRNAs in ischaemic cardiovascular diseases Open

Simona Greco, Germana Zaccagnini, Christine Voellenkle, Fabio Martelli · 2016

microRNAs (miRNAs) are non-coding RNA molecules that modulate the stability and/or the translational efficiency of specific messenger RNAs. They have been shown to play a regulatory role in most biological processes and their expression is…

Implication of Long noncoding RNAs in the endothelial cell response to hypoxia revealed by RNA-sequencing Open

Christine Voellenkle, José Manuel García-Manteiga, Simona Pedrotti, Alessandra Perfetti, Ilario De Toma , et al. · 2016

Long noncoding RNAs (lncRNAs) are non-protein coding RNAs regulating gene expression. Although for some lncRNAs a relevant role in hypoxic endothelium has been shown, the regulation and function of lncRNAs is still largely unknown in the v…

MOESM1 of Long noncoding RNA dysregulation in ischemic heart failure Open

Simona Greco, Germana Zaccagnini, Alessandra Perfetti, Paola Fuschi, Rea Valaperta , et al. · 2016

Additional file 1: Table S1. Disease association of the lncRNAs of the SBI "Disease-related human lncRNA profiler" plate. Table S2: Sequences and gene alignment of the primers designed for validation. Table S3: Single nucleotide polymorphi…

Magnetic Resonance Imaging Allows the Evaluation of Tissue Damage and Regeneration in a Mouse Model of Critical Limb Ischemia Open

Germana Zaccagnini, Anna Palmisano, Tamara Canu, Biagina Maimone, Francesco Maria Lo Russo , et al. · 2015

Magnetic resonance imaging (MRI) provides non-invasive, repetitive measures in the same individual, allowing the study of a physio-pathological event over time. In this study, we tested the performance of 7 Tesla multi-parametric MRI to mo…

Proliferation of Multiple Cell Types in the Skeletal Muscle Tissue Elicited by Acute p21 Suppression Open

Maria Grazia Biferi, Carmine Nicoletti, Germana Falcone, E. M. R. Puggioni, Nunzia Passaro , et al. · 2015

Although in the last decades the molecular underpinnings of the cell cycle have been unraveled, the acquired knowledge has been rarely translated into practical applications. Here, we investigate the feasibility and safety of triggering pr…

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