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View article: Lactate Transport via Glial <scp>MCT1</scp> and Neuronal <scp>MCT2</scp> Is Not Required for Synchronized Synaptic Transmission in Hippocampal Slices Supplied With Glucose
Lactate Transport via Glial <span>MCT1</span> and Neuronal <span>MCT2</span> Is Not Required for Synchronized Synaptic Transmission in Hippocampal Slices Supplied With Glucose Open
The metabolite lactate (L‐lactate) has been hypothesized to represent an important energy source during brain activation. The contribution of lactate in fueling synchronized synaptic transmission during fast neural network oscillations und…
View article: Periodic fasting induced reconstitution of metabolic flexibility improves albuminuria in patients with type 2 diabetes
Periodic fasting induced reconstitution of metabolic flexibility improves albuminuria in patients with type 2 diabetes Open
These findings demonstrate that diet-induced restoration of metabolic flexibility is associated with improved albuminuria in T2D, suggesting broader implications for precise nutritional strategies in diabetes management.
View article: mTORC1 senses glutamine and other amino acids through GCN2
mTORC1 senses glutamine and other amino acids through GCN2 Open
mTORC1 promotes cell growth when nutrients such as amino acids are available. While dedicated sensors relaying availability of leucine, arginine and methionine to mTORC1 have been identified, it is still unclear how mTORC1 senses glutamine…
View article: RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α
RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α Open
View article: Myeloid-specific deficiency of group VIA calcium-independent phospholipase A2 preconditions myeloid cells for injury resolution after acetaminophen exposure
Myeloid-specific deficiency of group VIA calcium-independent phospholipase A2 preconditions myeloid cells for injury resolution after acetaminophen exposure Open
Genetic PLA2G6 variants are associated with C-reactive protein in humans. Myeloid-specific PLA2G6-deficient (Pla2g6M-/-) mice show increased hepatic myeloperoxidase and recruitment of granulocytes in response to lipopolysacchari…
View article: Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolism
Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolism Open
View article: A metabolism-chromatin axis promotes ribosome heterogeneity in the human malaria parasite
A metabolism-chromatin axis promotes ribosome heterogeneity in the human malaria parasite Open
The transmission of the most virulent human malaria parasite, Plasmodium falciparum , relies on its survival in the contrasting environments of the human host and mosquito vector. One of the most fascinating adaptations to this lifestyle i…
View article: Exercise‐induced effects on the metabolome of endurance and strength‐trained athletes in comparison with sedentary subjects: A pilot study
Exercise‐induced effects on the metabolome of endurance and strength‐trained athletes in comparison with sedentary subjects: A pilot study Open
Little is known about the exercise‐induced adaptations of the metabolome in endurance and strength athletes in comparison with sedentary subjects. In order to analyze exercise‐induced effects, quantitative, targeted metabolomics (Biocrates…
View article: A Novel Missense Variant in Ultrarare SLC35A1‐CDG Alters Cellular Glycosylation, Lipid, and Energy Metabolism Without Affecting CDG Serum Markers
A Novel Missense Variant in Ultrarare SLC35A1‐CDG Alters Cellular Glycosylation, Lipid, and Energy Metabolism Without Affecting CDG Serum Markers Open
SLC35A1‐CDG is a very rare type of congenital disorders of glycosylation (CDG) with only five cases known to date. Here, we review the literature and present new data from a sixth patient carrying the uncharacterized variant c.133A>G; p.Th…
View article: Dipeptides in CSF and plasma: diagnostic and therapeutic potential in neurological diseases
Dipeptides in CSF and plasma: diagnostic and therapeutic potential in neurological diseases Open
View article: <sup>13</sup>C stable isotope tracing reveals distinct fatty acid oxidation pathways in proliferative versus oxidative cells
<sup>13</sup>C stable isotope tracing reveals distinct fatty acid oxidation pathways in proliferative versus oxidative cells Open
By using 13 C stable isotope-resolved metabolomics and FA-driven oxygen consumption rate analysis, our study provides novel insights into the fate of FA carbon through β-oxidation and downstream TCA cycle in proliferative and oxidative cel…
View article: Interlaboratory comparison of standardised metabolomics and lipidomics analyses in human and rodent blood using the MxP® Quant 500 kit
Interlaboratory comparison of standardised metabolomics and lipidomics analyses in human and rodent blood using the MxP® Quant 500 kit Open
Metabolomics and lipidomics are pivotal in understanding phenotypic variations beyond genomics. However, quantification and comparability of mass spectrometry (MS)-derived data are challenging. Standardised assays can enhance data comparab…
View article: TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia
TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia Open
Hypoglycemia triggers autonomic and endocrine counter-regulatory responses to restore glucose homeostasis, a response that is impaired in patients with diabetes and its long-term complication hypoglycemia-associated autonomic failure (HAAF…
View article: Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma
Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma Open
After recognizing its ligand lipopolysaccharide, Toll-like receptor 4 (TLR4) recruits adaptor proteins to the cell membrane, thereby initiating downstream signaling and triggering inflammation. Whether this recruitment of adaptor proteins …
View article: A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens
A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens Open
View article: Navigating the frontier: research infrastructures, core facilities and a new paradigm at European Universities
Navigating the frontier: research infrastructures, core facilities and a new paradigm at European Universities Open
Research Infrastructures (RI) and Core Facilities (CF) are strong drivers for generating research results and, thus, knowledge at European Universities. In this paper, we provide insight into different features of RI and CF, their organisa…
View article: Metabolic flexibility ensures proper neuronal network function in moderate neuroinflammation
Metabolic flexibility ensures proper neuronal network function in moderate neuroinflammation Open
View article: Knock‐out of dipeptidase <scp>CN2</scp> in human proximal tubular cells disrupts dipeptide and amino acid homeostasis and para‐ and transcellular solute transport
Knock‐out of dipeptidase <span>CN2</span> in human proximal tubular cells disrupts dipeptide and amino acid homeostasis and para‐ and transcellular solute transport Open
Aim Although of potential biomedical relevance, dipeptide metabolism has hardly been studied. We found the dipeptidase carnosinase‐2 (CN2) to be abundant in human proximal tubules, which regulate water and solute homeostasis. We therefore …
View article: The unfolded protein response-glutathione metabolism axis: A novel target of a cycloruthenated complexes bypassing tumor resistance mechanisms
The unfolded protein response-glutathione metabolism axis: A novel target of a cycloruthenated complexes bypassing tumor resistance mechanisms Open
View article: Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity
Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity Open
Glioblastoma is a deadly brain tumor for which there is no cure. The presence of glioblastoma stem-like cells (GSCs) contributes to the heterogeneous nature of the disease and makes developing effective therapies challenging. Glioblastoma …
View article: Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism
Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism Open
Cell metabolism reprogramming to sustain energy production, while reducing oxygen and energy consuming processes is crucially important for the adaptation to hypoxia/ischemia. Adaptive metabolic rewiring is controlled by hypoxia-inducible …
View article: Impaired Detoxification of Trans, Trans‐2,4‐Decadienal, an Oxidation Product from Omega‐6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease
Impaired Detoxification of Trans, Trans‐2,4‐Decadienal, an Oxidation Product from Omega‐6 Fatty Acids, Alters Insulin Signaling, Gluconeogenesis and Promotes Microvascular Disease Open
Omega‐6 fatty acids are the primary polyunsaturated fatty acids in most Western diets, while their role in diabetes remains controversial. Exposure of omega‐6 fatty acids to an oxidative environment results in the generation of a highly re…
View article: A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens
A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens Open
Understanding the interplay of the proteome and the metabolome aids in understanding cellular phenotypes. To enable more robust inferences from such multi-omics analyses, combining proteomic and metabolomic datasets from the same sample pr…
View article: SUMOylation Modulates Reactive Oxygen Species (ROS) Levels and Acts as a Protective Mechanism in the Type 2 Model of Diabetic Peripheral Neuropathy
SUMOylation Modulates Reactive Oxygen Species (ROS) Levels and Acts as a Protective Mechanism in the Type 2 Model of Diabetic Peripheral Neuropathy Open
Diabetic peripheral neuropathy (DPN) is the prevalent type of peripheral neuropathy; it primarily impacts extremity nerves. Its multifaceted nature makes the molecular mechanisms of diabetic neuropathy intricate and incompletely elucidated…
View article: Publisher Correction: Inhibition of fatty acid oxidation enables heart regeneration in adult mice
Publisher Correction: Inhibition of fatty acid oxidation enables heart regeneration in adult mice Open
View article: The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate
The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate Open
The malate shuttle is traditionally understood to maintain NAD + /NADH balance between the cytosol and mitochondria. Whether the malate shuttle has additional functions is unclear. Here we show that chronic viral infections induce CD8 + T …
View article: Inhibition of fatty acid oxidation enables heart regeneration in adult mice
Inhibition of fatty acid oxidation enables heart regeneration in adult mice Open
View article: Altered iron-sulfur cluster transfer in Arabidopsis mitochondria reveals lipoyl synthase as a Janus-faced enzyme that generates toxic sulfide
Altered iron-sulfur cluster transfer in Arabidopsis mitochondria reveals lipoyl synthase as a Janus-faced enzyme that generates toxic sulfide Open
Iron–sulfur (Fe–S) cluster are vital cofactors in all domains of life. Mitochondrial Fe–S cluster assembly occurs in two major steps to first build [2Fe–2S] clusters and subsequently assemble these into [4Fe–4S] clusters. The two assembly …
View article: P438: INTRACELLULAR CITRATE LEVELS MODULATE ANTI-APOPTOTIC PROTEINS TO ENHANCE VENETOCLAX SENSITIVITY IN ACUTE MYELOID LEUKEMIA STEM CELLS
P438: INTRACELLULAR CITRATE LEVELS MODULATE ANTI-APOPTOTIC PROTEINS TO ENHANCE VENETOCLAX SENSITIVITY IN ACUTE MYELOID LEUKEMIA STEM CELLS Open
Background: Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy with poor overall survival. While classic chemotherapy and novel agents, such as Venetoclax, lead to remission in majority of patients, relapses driven by the…
View article: Targeted Metabolomics in High Performance Sports: Differences between the Resting Metabolic Profile of Endurance- and Strength-Trained Athletes in Comparison with Sedentary Subjects over the Course of a Training Year
Targeted Metabolomics in High Performance Sports: Differences between the Resting Metabolic Profile of Endurance- and Strength-Trained Athletes in Comparison with Sedentary Subjects over the Course of a Training Year Open
Little is known about the metabolic differences between endurance and strength athletes in comparison with sedentary subjects under controlled conditions and about variation of the metabolome throughout one year. We hypothesized that (1) t…