Gert Flik
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View article: Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish
Melatonin as an anti-stress signal: effects on an acute stress model and direct actions on interrenal tissue in goldfish Open
Background Melatonin is a key hormone in regulation of circadian rhythms, and involved in many rhythmic functions, such as feeding and locomotor activity. Melatonin reportedly counteracts stress responses in many vertebrates, including fis…
View article: Additional file 6 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease
Additional file 6 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease Open
Additional file 6. Data file containing the PANTHER reactome of DEGs. Excel file with output from PANTHER reactome with DEGs.
View article: Additional file 7 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease
Additional file 7 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease Open
Additional file 7. Summary of results of gene-set enrichment analysis involving DEGs and human orthologues that cause different skeletal dysplasia subgroups in humans when mutated. Excel file containing a table with nosology enrichment ana…
View article: Additional file 3 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease
Additional file 3 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease Open
Additional file 3. List of differentially expressed genes. Excel file containing list of genes classed as differentially expressed.
View article: Additional file 1 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease
Additional file 1 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease Open
Additional file 1. List of protein coding genes consistently expressed in ontogenetic and regenerating scales. Excel file containing all protein coding genes and expression values that were captured during RNA-seq experiment.
View article: Additional file 5 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease
Additional file 5 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease Open
Additional file 5. Data output files of PANTHER Overrepresentation Test of process / function / component GO accession numbers and PANTHER Pathway analysis of DEGs. Excel file with several tabs containing outputs of various PANTHER analyse…
View article: Additional file 8 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease
Additional file 8 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease Open
Additional file 8. MAGMA gene level analysis results quantifying the strength of association between human orthologues of DEG’s and estimated bone mineral density, height and osteoarthritis.
View article: Additional file 4 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease
Additional file 4 of Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease Open
Additional file 4. Gene Ontology data file of DEG using GOrilla. Excel file with several tabs containing outputs from GOrilla GO analyses.
View article: Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics
Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics Open
Pheochromocytomas and paragangliomas (PPGLs) caused by mutations in the B-subunit of the succinate dehydrogenase ( SDHB ) have the highest metastatic rate among PPGLs, and effective systemic therapy is lacking. To unravel underlying pathog…
View article: The transcriptome of regenerating zebrafish scales identifies genes involved in human bone disease
The transcriptome of regenerating zebrafish scales identifies genes involved in human bone disease Open
Zebrafish scales are mineralised plates that can regenerate involving de novo bone formation. This presents an opportunity to uncover genes and pathways relevant to human musculoskeletal disease relevant to impaired bone formation. To inve…
View article: Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Danio rerio) Larvae
Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Danio rerio) Larvae Open
In this study we have assessed the effects of increased cortisol levels during early embryonic development on immune function in zebrafish (Danio rerio) larvae. Fertilized eggs were exposed to either a cortisol-containing, a dexamethasone-…
View article: Triploidy in zebrafish larvae: Effects on gene expression, cell size and cell number, growth, development and swimming performance
Triploidy in zebrafish larvae: Effects on gene expression, cell size and cell number, growth, development and swimming performance Open
This dataset contains raw data of gene expression levels, cell size, cell number, growth, development and swimming performance of diploid and triploid larval zebrafish, used for analyses and figures of the PLOS ONE paper: Triploidy in zebr…
View article: Early life glucocorticoid exposure modulates immune function in zebrafish (<i>Danio rerio</i>) larvae
Early life glucocorticoid exposure modulates immune function in zebrafish (<i>Danio rerio</i>) larvae Open
In this study we have assessed the effects of increased cortisol levels during early embryonic development on immune function in zebrafish ( Danio rerio ) larvae. Fertilized eggs were exposed to either a cortisol-containing, a dexamethason…
View article: The ezh2(sa1199) mutant zebrafish display no distinct phenotype
The ezh2(sa1199) mutant zebrafish display no distinct phenotype Open
Polycomb group (PcG) proteins are essential regulators of epigenetic gene silencing and development. The PcG protein enhancer of zeste homolog 2 (Ezh2) is a key component of the Polycomb Repressive Complex 2 and is responsible for placing …
View article: Dissection of intestines from larval zebrafish for molecular analysis
Dissection of intestines from larval zebrafish for molecular analysis Open
Epigenetic data obtained from whole zebrafish embryos or larvae may mask or dilute organ-specific information. Fluorescence activated cell sorting can diverge cells from their native state, and cryosections often yield insufficient materia…
View article: Allostatic Load and Stress Physiology in European Seabass (Dicentrarchus labrax L.) and Gilthead Seabream (Sparus aurata L.)
Allostatic Load and Stress Physiology in European Seabass (Dicentrarchus labrax L.) and Gilthead Seabream (Sparus aurata L.) Open
The present study aimed to compare effects of increasing chronic stress load on the stress response of European seabass (Dicentrarchus labrax) and gilthead seabream (Sparus aurata) to identify neuroendocrine functions that regulate this re…
View article: EFFECTS OF STRESS ON BEHAVIOR AND SLEEP. CORTISOL: A STRESS HORMONE AND A WAKE HORMONE?
EFFECTS OF STRESS ON BEHAVIOR AND SLEEP. CORTISOL: A STRESS HORMONE AND A WAKE HORMONE? Open
This review is dedicated to the role of cortisol in behavior and sleep grounded on evidence-based information that acute and chronic stress (in particular the stress-induced release of glucocorticoids), induce changes in glutamate neurotra…
View article: Further characterisation of differences between TL and AB zebrafish (Danio rerio): Gene expression, physiology and behaviour at day 5 of the larval stage
Further characterisation of differences between TL and AB zebrafish (Danio rerio): Gene expression, physiology and behaviour at day 5 of the larval stage Open
Zebrafish (Danio rerio) have become popular as model organism in research. Many strains are readily available, which not only differ morphologically, but also genetically, physiologically and behaviourally. Here, we focus on the AB and Tup…
View article: Comparative Physiology of Energy Metabolism: Fishing for Endocrine Signals in the Early Vertebrate Pool
Comparative Physiology of Energy Metabolism: Fishing for Endocrine Signals in the Early Vertebrate Pool Open
Energy is the common currency of life. To guarantee a homeostatic supply of energy, multiple neuro-endocrine systems have evolved in vertebrates; systems that regulate food intake, metabolism, and distribution of energy. Even subtle (lasti…
View article: Light regimes differentially affect baseline transcript abundance of stress-axis and (neuro)development related genes in zebrafish (<i>Danio rerio</i>, Hamilton 1822) AB and TL larvae
Light regimes differentially affect baseline transcript abundance of stress-axis and (neuro)development related genes in zebrafish (<i>Danio rerio</i>, Hamilton 1822) AB and TL larvae Open
Many strains of zebrafish (Danio rerio) are readily available. Earlier we observed differences between AB and Tupfel long-fin (TL) larvae regarding baseline hypothalamus-pituitary-interrenal (HPI) axis activity and (neuro)development. Ligh…
View article: How do individuals cope with stress? Behavioural, physiological and neuronal differences between proactive and reactive coping styles in fish
How do individuals cope with stress? Behavioural, physiological and neuronal differences between proactive and reactive coping styles in fish Open
Despite the use of fish models to study human mental disorders and dysfunctions, knowledge of regional telencephalic responses in non-mammalian vertebrates expressing alternate stress coping styles is poor. Since perception of salient stim…
View article: Brain serotonergic activation in growth-stunted farmed salmon: adaption versus pathology
Brain serotonergic activation in growth-stunted farmed salmon: adaption versus pathology Open
Signalling systems activated under stress are highly conserved, suggesting adaptive effects of their function. Pathologies arising from continued activation of such systems may represent a mismatch between evolutionary programming and curr…
View article: Effects of acute stress on aggression and the cortisol response in the <scp>A</scp>frican sharptooth catfish <i>Clarias gariepinus</i>: differences between day and night
Effects of acute stress on aggression and the cortisol response in the <span>A</span>frican sharptooth catfish <i>Clarias gariepinus</i>: differences between day and night Open
African sharptooth catfish Clarias gariepinus were housed under continuous dim light (1 lx) or 12L : 12D (350–0 lx) cycles. The number of skin lesions, as indicator of aggressive acts, and plasma cortisol levels, as indicator of stress‐axi…
View article: Branchial nitrogen cycle symbionts can remove ammonia in fish gills
Branchial nitrogen cycle symbionts can remove ammonia in fish gills Open
Summary Knowledge of the mechanisms by which fish excrete their metabolic nitrogenous waste and insights into nitrogen cycling in aquaculture systems is of utmost importance to improve the sustainable commercial production of fish. In fish…
View article: Outline based shape analysis of fish scales: a procedure to quentify skeletal effects of chronic stress
Outline based shape analysis of fish scales: a procedure to quentify skeletal effects of chronic stress Open
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