Gert Jan Scheffer
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View article: Early postoperative pain and 30-day complications following major abdominal surgery: a retrospective cohort study
Early postoperative pain and 30-day complications following major abdominal surgery: a retrospective cohort study Open
Background Increasing evidence supports a positive relationship between the intensity of early postoperative pain, and the risk of 30-day postoperative complications. Higher pain levels may hamper recovery and contribute to immunosuppressi…
View article: Recovery and immune function after low pressure pneumoperitoneum during robot‐assisted radical prostatectomy: a randomised controlled trial
Recovery and immune function after low pressure pneumoperitoneum during robot‐assisted radical prostatectomy: a randomised controlled trial Open
Objective To compare the effectiveness of low intra‐abdominal pressure (IAP) facilitated by deep neuromuscular block (NMB) to standard practice in improving the quality of recovery, preserving immune function, and enhancing parietal perfus…
View article: Trends in the use of neuromuscular blocking agents, reversal agents and neuromuscular transmission monitoring: a single-centre retrospective cohort study
Trends in the use of neuromuscular blocking agents, reversal agents and neuromuscular transmission monitoring: a single-centre retrospective cohort study Open
Background Residual neuromuscular blockade (rNMB) remains a persistent and preventable problem, with serious risks. Methods Our objective was to describe and assess patterns in the use of neuromuscular blocking agents (NMBAs), neuromuscula…
View article: NSAIDs affect dendritic cell cytokine production
NSAIDs affect dendritic cell cytokine production Open
Background Immunotherapy is now considered as the new pillar in treatment of cancer patients. Dendritic cells (DCs) play an essential role in stimulating anti-tumor immune responses, as they are capable of cross-presenting exogenous tumor …
View article: Transport of the patient with trauma: a narrative review
Transport of the patient with trauma: a narrative review Open
Summary Trauma and injury place a significant burden on healthcare systems. In most high‐income countries, well‐developed acute pre‐hospital and trauma care systems have been established. In Europe, mobile physician‐staffed medical teams a…
View article: Chronic postsurgical pain after minimally invasive adrenalectomy: prevalence and impact on quality of life
Chronic postsurgical pain after minimally invasive adrenalectomy: prevalence and impact on quality of life Open
View article: Non-invasive electrical cardiometry cardiac output monitoring during prehospital helicopter emergency medical care: a feasibility study
Non-invasive electrical cardiometry cardiac output monitoring during prehospital helicopter emergency medical care: a feasibility study Open
Purpose Introducing advanced hemodynamic monitoring might be beneficial during Helicopter Emergency Medical Service (HEMS) care. However, it should not increase the on-scene-time, it should be easy to use and should be non-invasive. The go…
View article: Clinical evaluation of the Trachospray device for upper airway anaesthesia
Clinical evaluation of the Trachospray device for upper airway anaesthesia Open
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View article: Comparative in-vitro Study of the Trachospray, a New Device for Topical Anaesthesia of the Upper Airway
Comparative in-vitro Study of the Trachospray, a New Device for Topical Anaesthesia of the Upper Airway Open
The Trachospray device deposits local anaesthetics in the targeted areas for topical anaesthesia of the airway and has promising characteristics for providing effective airway anaesthesia.
View article: Four different methods of measuring cardiac index during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Four different methods of measuring cardiac index during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy Open
BackgroundCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are high-risk extensive abdominal surgery. During high-risk surgery, less invasive methods for cardiac index (CI) measurement have been widely used…
View article: Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes
Tumor ablation plus co-administration of CpG and saponin adjuvants affects IL-1 production and multifunctional T cell numbers in tumor draining lymph nodes Open
Background Tumor ablation techniques, like cryoablation, are successfully used in the clinic to treat tumors. The tumor debris remaining in situ after ablation is a major antigen depot, including neoantigens, which are presented by dendrit…
View article: Thermal distribution, physiological effects and toxicities of extracorporeally induced whole‐body hyperthermia in a pig model
Thermal distribution, physiological effects and toxicities of extracorporeally induced whole‐body hyperthermia in a pig model Open
Fast induction of eWBH with homogenous thermal distribution is feasible in pigs using the Vithèr WBH device. Severe hemodynamic disturbances, rhabdomyolysis, and hyperkalemia were observed.
View article: The effect of analgesics on stimulus evoked pain-like behaviour in animal models for chemotherapy induced peripheral neuropathy- a meta-analysis
The effect of analgesics on stimulus evoked pain-like behaviour in animal models for chemotherapy induced peripheral neuropathy- a meta-analysis Open
Chemotherapy induced painful peripheral neuropathy (CIPN) is a common dose-limiting side effect of several chemotherapeutic agents. Despite large amounts of human and animal studies, there is no sufficiently effective pharmacological treat…
View article: A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN)
A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN) Open
Despite the large amount of human and experimental studies no effective (prophylactic) treatment exists for chemotherapy induced peripheral neuropathy (CIPN), a disabling side effect of many cancer treatments. One of the underlying reasons…
View article: Emergency front‐of‐neck airway by ENT surgeons and residents: A dutch national survey
Emergency front‐of‐neck airway by ENT surgeons and residents: A dutch national survey Open
Objectives ENT surgeons and anesthesiologists work closely together in managing challenging airway cases. Sharing knowledge, experiences, and expectations interdisciplinary is essential in order to facilitate decision‐making and adequate m…
View article: Shared decision-making for postoperative analgesia
Shared decision-making for postoperative analgesia Open
The results of this study suggest that both patients and professionals did not adhere to some 'self-evident' principles of SDM when postoperative analgesia after major thoracic and abdominal surgery was discussed.
View article: Femoral nerve catheter vs local infiltration for analgesia in fast track total knee arthroplasty: short-term and long-term outcomes
Femoral nerve catheter vs local infiltration for analgesia in fast track total knee arthroplasty: short-term and long-term outcomes Open
View article: ABCDE of prehospital ultrasonography: a narrative review
ABCDE of prehospital ultrasonography: a narrative review Open
Prehospital point-of-care ultrasound used by nonradiologists in emergency medicine is gaining ground. It is feasible on-scene and during aeromedical transport and allows health-care professionals to detect or rule out potential harmful con…
View article: Emergency physicians’ attitudes to implementing ultrasound in Dutch emergency departments after a 2-day training: A qualitative study
Emergency physicians’ attitudes to implementing ultrasound in Dutch emergency departments after a 2-day training: A qualitative study Open
Background: Diagnostic ultrasound is increasingly used by nonradiologists in trauma victims and critically ill patients. In the emergency department, the extended focused assessment with sonography for trauma and Polytrauma Rapid Echo-eval…
View article: Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Increased Plasma Levels of Danger-Associated Molecular Patterns Are Associated With Immune Suppression and Postoperative Infections in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Open
CRS-HIPEC is associated with profound DAMP release and immune suppression, and plasma HMGB1 levels are related with the occurrence of postoperative infections in these patients.
View article: Prehospital Echocardiography During Resuscitation Impacts Treatment in a Physician-Staffed Helicopter Emergency Medical Service: an Observational Study
Prehospital Echocardiography During Resuscitation Impacts Treatment in a Physician-Staffed Helicopter Emergency Medical Service: an Observational Study Open
Prehospital echocardiography has an impact on patient treatment and may be a useful tool to support decision-making during CPR in a Dutch HEMS.
View article: Quality of Recovery After Low‐Pressure Laparoscopic Donor Nephrectomy Facilitated by Deep Neuromuscular Blockade: A Randomized Controlled Study
Quality of Recovery After Low‐Pressure Laparoscopic Donor Nephrectomy Facilitated by Deep Neuromuscular Blockade: A Randomized Controlled Study Open
Background The use of low intra‐abdominal pressure (<10 mmHg) reduces postoperative pain scores after laparoscopic surgery. Objective To investigate whether low‐pressure pneumoperitoneum with deep neuromuscular blockade improves the qualit…
View article: Deep neuromuscular block to optimize surgical space conditions during laparoscopic surgery: a systematic review and meta-analysis
Deep neuromuscular block to optimize surgical space conditions during laparoscopic surgery: a systematic review and meta-analysis Open
View article: Erratum zum Beitrag: Vitamin C beim chronischen nicht spezifischen Kreuzschmerz
Erratum zum Beitrag: Vitamin C beim chronischen nicht spezifischen Kreuzschmerz Open
View article: Pharmacokinetics of 400 mg ropivacaine after periarticular local infiltration analgesia for total knee arthroplasty
Pharmacokinetics of 400 mg ropivacaine after periarticular local infiltration analgesia for total knee arthroplasty Open
Background Although considered safe, no pharmacokinetic data of high dose, high volume local infiltration analgesia (LIA) with ropivacaine without the use of a surgical drain or intra‐articular catheter have been described. The purpose of …
View article: A Systematic Review of the Modifying Effect of Anaesthetic Drugs on Metastasis in Animal Models for Cancer
A Systematic Review of the Modifying Effect of Anaesthetic Drugs on Metastasis in Animal Models for Cancer Open
Anaesthetics influence the number and incidence of metastases in experimental cancer models. Although more high quality experimental research is necessary, based on the currently available evidence from animal studies, there is no indicati…
View article: Strategies to optimize respiratory muscle function in ICU patients
Strategies to optimize respiratory muscle function in ICU patients Open
View article: Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients
Plasma levels of danger-associated molecular patterns are associated with immune suppression in trauma patients Open
View article: Effect of local anesthetic concentration, dose and volume on the duration of single-injection ultrasound-guided axillary brachial plexus block with mepivacaine: a randomized controlled trial
Effect of local anesthetic concentration, dose and volume on the duration of single-injection ultrasound-guided axillary brachial plexus block with mepivacaine: a randomized controlled trial Open
View article: Comparison of the effectiveness of low pressure pneumoperitoneum with profound muscle relaxation during laparoscopic donor nephrectomy to optimize the quality of recovery during the early post-operative phase: study protocol for a randomized controlled clinical trial
Comparison of the effectiveness of low pressure pneumoperitoneum with profound muscle relaxation during laparoscopic donor nephrectomy to optimize the quality of recovery during the early post-operative phase: study protocol for a randomized controlled clinical trial Open