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View article: Π-Π stacking stabilized polymeric micelles for hydrophobic drug delivery in the treatment of leishmaniasis
Π-Π stacking stabilized polymeric micelles for hydrophobic drug delivery in the treatment of leishmaniasis Open
Current control strategies for leishmaniases - a group of diseases caused by protozoan parasites of the genus Leishmania - rely on chemotherapy, which is often associated with significant drawbacks, including severe side effects and limite…
View article: Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH
Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH Open
Increasing evidence implicates ceramides in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH). However, the therapeutic potential of liver-targeted ceramide lowering remains unclear. In this study, we demonstrate …
View article: Gut‐liver axis: Potential mechanisms of action of food‐derived extracellular vesicles
Gut‐liver axis: Potential mechanisms of action of food‐derived extracellular vesicles Open
Food‐derived extracellular vesicles (FEVs) are nanoscale membrane vesicles obtained from dietary materials such as breast milk, plants and probiotics. Distinct from other EVs, FEVs can survive the harsh degrading conditions in the gastroin…
View article: Vaccination with DC-SIGN-Targeting αGC Liposomes Leads to Tumor Control, Irrespective of Suboptimally Activated T-Cells
Vaccination with DC-SIGN-Targeting αGC Liposomes Leads to Tumor Control, Irrespective of Suboptimally Activated T-Cells Open
Cancer vaccines have emerged as a potent strategy to improve cancer immunity, with or without the combination of checkpoint blockade. In our investigation, liposomal formulations containing synthetic long peptides and α-Galactosylceramide,…
View article: Comparative analysis of whole cell-derived vesicular delivery systems for photodynamic therapy of extrahepatic cholangiocarcinoma
Comparative analysis of whole cell-derived vesicular delivery systems for photodynamic therapy of extrahepatic cholangiocarcinoma Open
This first-in-its-class proof-of-concept study explored the use of bionanovesicles for the delivery of photosensitizer into cultured cholangiocarcinoma cells and subsequent treatment by photodynamic therapy (PDT). Two types of bionanovesic…
View article: Modulated Electro-Hyperthermia Accelerates Tumor Delivery and Improves Anticancer Activity of Doxorubicin Encapsulated in Lyso-Thermosensitive Liposomes in 4T1-Tumor-Bearing Mice
Modulated Electro-Hyperthermia Accelerates Tumor Delivery and Improves Anticancer Activity of Doxorubicin Encapsulated in Lyso-Thermosensitive Liposomes in 4T1-Tumor-Bearing Mice Open
Modulated electro-hyperthermia (mEHT) is an adjuvant cancer therapy that enables tumor-selective heating (+2.5 °C). In this study, we investigated whether mEHT accelerates the tumor-specific delivery of doxorubicin (DOX) from lyso-thermose…
View article: Platelets interact with CD169+ macrophages and cDC1 and enhance liposome-induced CD8+ T cell responses
Platelets interact with CD169+ macrophages and cDC1 and enhance liposome-induced CD8+ T cell responses Open
Historically platelets are mostly known for their crucial contribution to hemostasis, but there is growing understanding of their role in inflammation and immunity. The immunomodulatory role of platelets entails interaction with pathogens,…
View article: Evaluation of a steroid delivery system to mitigate the severity of proliferative vitreoretinopathy in a minipig model
Evaluation of a steroid delivery system to mitigate the severity of proliferative vitreoretinopathy in a minipig model Open
Purpose To investigate the efficacy of liposomal prednisolone phosphate to mitigate the severity of proliferative vitreoretinopathy (PVR) in a minipig model of PVR. Methods A total of 18 eyes of 9 minipigs underwent PVR induction surgicall…
View article: Current status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors
Current status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors Open
Diseases affecting the esophagus are common. However, targeted drug delivery to the esophagus is challenging due to the anatomy and physiology of this organ. Current pharmacological treatment for esophageal diseases predominantly relies on…
View article: Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis
Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis Open
Milk-derived extracellular vesicles (mEVs) have been proposed as a potential nanomedicine for intestinal disorders; however, their impact on intestinal barrier integrity in gut inflammation and associated metabolic diseases has not been ex…
View article: Microbubble-Assisted Ultrasound for Drug Delivery to the Retina in an Ex Vivo Eye Model
Microbubble-Assisted Ultrasound for Drug Delivery to the Retina in an Ex Vivo Eye Model Open
Drug delivery to the retina is one of the major challenges in ophthalmology due to the biological barriers that protect it from harmful substances in the body. Despite the advancement in ocular therapeutics, there are many unmet needs for …
View article: Supplementary Figure Legend from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Supplementary Figure Legend from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells Open
PDF file - 53K
View article: Supplementary Figure 3 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Supplementary Figure 3 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells Open
PDF file - 111K, GVHD and GvT regulation in the LME-1 MM tumor model. (A) GvHD scores at weeks 3, 4,and 5. The total score is the sum of the scores for weight loss ( 0=0-10 %; 1=10-20%; 2=>20%. ) , mobility (0= mobile; 1= diminished mobili…
View article: Supplementary Figure 1 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Supplementary Figure 1 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells Open
PDF file - 49K, Ex vivo expansion and suppressor capacity of Tregs. (A) Ex vivo expansion rate of CD4+CD25+ Tregs isolated from peripheral blood. (B) Suppressive activity of ex vivo cultured Tregs on CD4+CD25- effector T cells stimulated w…
View article: Supplementary Figure 3 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Supplementary Figure 3 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells Open
PDF file - 111K, GVHD and GvT regulation in the LME-1 MM tumor model. (A) GvHD scores at weeks 3, 4,and 5. The total score is the sum of the scores for weight loss ( 0=0-10 %; 1=10-20%; 2=>20%. ) , mobility (0= mobile; 1= diminished mobili…
View article: Supplementary Figure Legend from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Supplementary Figure Legend from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells Open
PDF file - 53K
View article: Supplementary Figure 2 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Supplementary Figure 2 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells Open
PDF file - 54K, Human Tregs allow GvT against murine lymphoma tumors. Human PBMC were infused alone or together with expanded human Tregs to treat immune deficient mice carrying murine Luciferase+ A20 lymphoma cells in the bone marrow. PBM…
View article: Supplementary Figure 2 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Supplementary Figure 2 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells Open
PDF file - 54K, Human Tregs allow GvT against murine lymphoma tumors. Human PBMC were infused alone or together with expanded human Tregs to treat immune deficient mice carrying murine Luciferase+ A20 lymphoma cells in the bone marrow. PBM…
View article: Supplementary Figure 1 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Supplementary Figure 1 from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells Open
PDF file - 49K, Ex vivo expansion and suppressor capacity of Tregs. (A) Ex vivo expansion rate of CD4+CD25+ Tregs isolated from peripheral blood. (B) Suppressive activity of ex vivo cultured Tregs on CD4+CD25- effector T cells stimulated w…
View article: Data from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Data from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells Open
Purpose: Regulatory T cells (Tregs) are potent tools to prevent graft-versus-host disease (GVHD) induced after allogeneic stem cell transplantation or donor lymphocyte infusions. Toward clinical application of Tregs for GVHD treatment, we …
View article: Data from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Data from Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells Open
Purpose: Regulatory T cells (Tregs) are potent tools to prevent graft-versus-host disease (GVHD) induced after allogeneic stem cell transplantation or donor lymphocyte infusions. Toward clinical application of Tregs for GVHD treatment, we …
View article: Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management
Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management Open
The aggressiveness of melanoma and lack of effective therapies incite the discovery of novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene and a ʟ-tyrosine analogue, was synthesized. HM was designed to …
View article: Utility of Intravenous Curcumin Nanodelivery Systems for Improving <i>In Vivo</i> Pharmacokinetics and Anticancer Pharmacodynamics
Utility of Intravenous Curcumin Nanodelivery Systems for Improving <i>In Vivo</i> Pharmacokinetics and Anticancer Pharmacodynamics Open
Curcumin nanoformulations for intravenous injection have been developed to offset poor absorption, biotransformation, degradation, and excessive clearance associated with parenteral delivery. This review investigates (1) whether intravenou…
View article: Imaged-guided focused ultrasound in combination with various formulations of doxorubicin for the treatment of diffuse intrinsic pontine glioma
Imaged-guided focused ultrasound in combination with various formulations of doxorubicin for the treatment of diffuse intrinsic pontine glioma Open
Background Diffuse intrinsic pontine glioma (DIPG) is a notoriously difficult tumor to treat, with an overall survival of DIPG patients being only 11 months. One of the major obstacles for the effective treatment of DIPG is the blood–brain…