Gertrude Ecklu-Mensah
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View article: Toxic metals impact gut microbiota and metabolic risk in five African-origin populations
Toxic metals impact gut microbiota and metabolic risk in five African-origin populations Open
Underlying mechanisms by which exposures to toxic metals/metalloids impact obesity and type 2 diabetes (T2DM) risk remain largely unknown. Gut microbiota have been strongly associated with cardiometabolic risk. To assess relationships betw…
View article: Modulating the human gut microbiome and health markers through kombucha consumption: a controlled clinical study
Modulating the human gut microbiome and health markers through kombucha consumption: a controlled clinical study Open
Fermented foods are becoming more popular due to their purported links to metabolic health and the gut microbiome. However, direct clinical evidence for the health claims is lacking. Here, we describe an eight-week clinical trial that expl…
View article: Toxic Metals Impact Gut Microbiota and Metabolic Risk in Five African-Origin Populations
Toxic Metals Impact Gut Microbiota and Metabolic Risk in Five African-Origin Populations Open
Exposure to toxic metals impacts obesity and type 2 diabetes (T2DM) risk. Yet, the underlying mechanisms remain largely unknown. Gut microbiota has been strongly associated with progression of cardiometabolic risk. To determine whether hig…
View article: 8513 Toxic Metals Are Associated With Increased Diabetes And Obesity Through Gut Microbiota Changes In Five African-Origin Populations
8513 Toxic Metals Are Associated With Increased Diabetes And Obesity Through Gut Microbiota Changes In Five African-Origin Populations Open
Disclosure: J. Jorgensen: None. C. Choo-Kang: None. L. Issa: None. J.A. Gilbert: None. G. Ecklu-Mensah: None. A. Luke: None. K. Bedu-Addo: None. T. Forrester: None. P. Bovet: None. E.V. Lambert: None. D. Rae: None. M. Argos: None. Y. Dai: …
View article: Modulating the Human Gut Microbiome and Health Markers through Kombucha Consumption: A Controlled Clinical Study
Modulating the Human Gut Microbiome and Health Markers through Kombucha Consumption: A Controlled Clinical Study Open
Fermented foods are surging in popularity globally due to their links to metabolic health and the gut microbiome. However, direct clinical evidence for the health claims is lacking. Here, we describe an eight-week clinical trial that explo…
View article: Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM
Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM Open
Disparities for women and minorities in science, technology, engineering, and math (STEM) careers have continued even amidst mounting evidence for the superior performance of diverse workforces. In response, we launched the Diversity and S…
View article: The re-emerging role of linoleic acid in paediatric asthma
The re-emerging role of linoleic acid in paediatric asthma Open
Asthma is the most common chronic disease within the paediatric population. Although it is multifactorial, its onset may be linked to early-life exposures with subsequent impact on immune system development. Microbial and dietary metabolic…
View article: The Microbiome, Metabolism, and Networks in Precision Nutrition
The Microbiome, Metabolism, and Networks in Precision Nutrition Open
The human microbiota comprises a diverse community of commensal and symbiotic microorganisms, namely, archaea, viruses, eukarya, and bacteria coexisting at different sites of the body. The genomes and ecological context of these microbial …
View article: FRI010 Human Gut Microbiota And Metabolic Profiles Are Associated With Obesity In Five African-Origin Populations
FRI010 Human Gut Microbiota And Metabolic Profiles Are Associated With Obesity In Five African-Origin Populations Open
Disclosure: J. Jorgensen: None. C. Choo-Kang: None. G. Ecklu-Mensah: None. J. Gilbert: None. A. Luke: None. K. Bedu-Addo: None. T.E. Forrester: None. P. Bovet: None. E.V. Lambert: None. D. Rae: None. L. Dugas: None. Y. Dai: None. B.T. Layd…
View article: Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: the METS-microbiome study
Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: the METS-microbiome study Open
The relationship between microbiota, short chain fatty acids (SCFAs), and obesity remains enigmatic. We employ amplicon sequencing and targeted metabolomics in a large ( n = 1904) African origin cohort from Ghana, South Africa, Jamaica, Se…
View article: Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: The METS-Microbiome Study
Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: The METS-Microbiome Study Open
The relationship between gut microbiota, short chain fatty acid (SCFA) metabolism, and obesity is still not well understood. Here we investigated these associations in a large (n=1904) African origin cohort from Ghana, South Africa, Jamaic…
View article: Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: The METS-Microbiome Study
Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: The METS-Microbiome Study Open
The relationship between the gut microbiota, short chain fatty acid (SCFA) metabolism, and obesity remains unclear due to conflicting reports from studies with limited statistical power. Additionally, this association has rarely been explo…
View article: Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: The METS-Microbiome Study
Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: The METS-Microbiome Study Open
The relationship between gut microbiota, short chain fatty acid (SCFA) metabolism, and obesity is still not well understood. Here we investigated these associations in a large (n=1904) African origin cohort from Ghana, South Africa, Jamaic…
View article: Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM
Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM Open
Disparities for women and minorities in science, technology, engineering, and math (STEM) careers have continued even amidst mounting evidence for the superior performance of diverse workforces. In response, we launched the Diversity and S…
View article: SARS-CoV-2 detection status associates with bacterial community composition in patients and the hospital environment
SARS-CoV-2 detection status associates with bacterial community composition in patients and the hospital environment Open
Background SARS-CoV-2 is an RNA virus responsible for the coronavirus disease 2019 (COVID-19) pandemic. Viruses exist in complex microbial environments, and recent studies have revealed both synergistic and antagonistic effects of specific…
View article: Additional file 12 of SARS-CoV-2 detection status associates with bacterial community composition in patients and the hospital environment
Additional file 12 of SARS-CoV-2 detection status associates with bacterial community composition in patients and the hospital environment Open
Additional file 11: Table S2. Top 100 random forest importance ranks and GreenGenes taxonomy from nares, forehead, stool, and inside floor samples.
View article: Microbial context predicts SARS-CoV-2 prevalence in patients and the hospital built environment
Microbial context predicts SARS-CoV-2 prevalence in patients and the hospital built environment Open
Synergistic effects of bacteria on viral stability and transmission are widely documented but remain unclear in the context of SARS-CoV-2. We collected 972 samples from hospitalized patients with coronavirus disease 2019 (COVID-19), their …
View article: Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C
Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C Open
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial pr…
View article: Assessment of bacterial diversity in western Accra, Ghana, drinking water samples
Assessment of bacterial diversity in western Accra, Ghana, drinking water samples Open
The design and performance characteristics of municipal drinking water systems can profoundly influence public health. To assess the operational attributes of an Accra, Ghana drinking water distribution system, high-throughput 454 pyrosequ…
View article: Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones
Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones Open
PfEMP1 is a family of adhesive proteins expressed on the surface of Plasmodium falciparum -infected erythrocytes (IEs), where they mediate adhesion of IEs to a range of host receptors. Efficient PfEMP1-dependent IE sequestration often depe…
View article: Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes
Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes Open
The lack of suitable animal models for the study of cytoadhesion of P. falciparum-infected erythrocytes (IEs) has necessitated in vitro studies employing a range of cell lines of either human tumour origin (e.g., BeWo and C32 cells) or non…
View article: Natural and Vaccine-Induced Acquisition of Cross-Reactive IgG-Inhibiting ICAM-1-Specific Binding of a Plasmodium falciparum PfEMP1 Subtype Associated Specifically with Cerebral Malaria
Natural and Vaccine-Induced Acquisition of Cross-Reactive IgG-Inhibiting ICAM-1-Specific Binding of a Plasmodium falciparum PfEMP1 Subtype Associated Specifically with Cerebral Malaria Open
Cerebral malaria (CM) is a potentially deadly outcome of Plasmodium falciparum malaria that is precipitated by sequestration of infected erythrocytes (IEs) in the brain. The adhesion of IEs to brain endothelial cells is mediated by a subty…
View article: Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria
Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria Open
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display parasite proteins of the PfEMP1 family that bind various endothel…