Gerwin J. Puppels
YOU?
Author Swipe
View article: Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope
Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope Open
Field cancerization (FC) refers to spatially distributed premalignant tissue changes that lead to the appearance of local malignancy, and its detection can improve cancer screening. In this work, we employ combined Raman and partial wave s…
View article: Hybrid Raman and Partial Wave Spectroscopy Microscope for the Characterization of Molecular and Structural Alterations in Tissue
Hybrid Raman and Partial Wave Spectroscopy Microscope for the Characterization of Molecular and Structural Alterations in Tissue Open
We present a hybrid Raman spectroscopy (RS) and partial wave spectroscopy (PWS) microscope for the characterization of molecular and structural tissue alterations. The PWS performance was assessed with surface roughness standards, while th…
View article: Limits of Detection of Topically Applied Products in the Skin Using In Vivo Raman Spectroscopy
Limits of Detection of Topically Applied Products in the Skin Using In Vivo Raman Spectroscopy Open
We have developed a method to determine the limit of detection (LoD) for quantitative measurement of exogenous analytes in the outer layer of the human skin by in vivo confocal Raman spectroscopy. The method is in accordance with the guide…
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: Data from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Data from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents Open
Raman spectroscopy is a noninvasive and label-free optical technique that provides detailed information about the molecular composition of a sample. In this study, we evaluated the potential of Raman spectroscopy to predict skin toxicity d…
View article: Supplementary Table S1 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Supplementary Table S1 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents Open
Summary of the measurements of the drug concentration into patients' blood.
View article: Supplementary Table S2 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Supplementary Table S2 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents Open
Summary of cutaneous adverse events at the different time point for each patient included in this study. n/a: not available
View article: Supplementary Information from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Supplementary Information from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents Open
Revised Supplementary Information
View article: Supplementary Figure S1 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Supplementary Figure S1 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents Open
Mean LD score for the validation data set for Stratum Corneum skin layer for MEK inhibitors (A), EGFR inhibitors (B) and BRAF inhibitors (C) and for Viable Epidermis skin layer for MEK inhibitors (D), EGFR inhibitors (E) and BRAF inhibitor…
View article: Supplementary Information from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Supplementary Information from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents Open
Revised Supplementary Information
View article: Supplementary Figure S1 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Supplementary Figure S1 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents Open
Mean LD score for the validation data set for Stratum Corneum skin layer for MEK inhibitors (A), EGFR inhibitors (B) and BRAF inhibitors (C) and for Viable Epidermis skin layer for MEK inhibitors (D), EGFR inhibitors (E) and BRAF inhibitor…
View article: Supplementary Table S2 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Supplementary Table S2 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents Open
Summary of cutaneous adverse events at the different time point for each patient included in this study. n/a: not available
View article: Supplementary Table S1 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Supplementary Table S1 from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents Open
Summary of the measurements of the drug concentration into patients' blood.
View article: Data from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents
Data from A Novel Spectroscopically Determined Pharmacodynamic Biomarker for Skin Toxicity in Cancer Patients Treated with Targeted Agents Open
Raman spectroscopy is a noninvasive and label-free optical technique that provides detailed information about the molecular composition of a sample. In this study, we evaluated the potential of Raman spectroscopy to predict skin toxicity d…
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: Development of a near-infrared Raman spectroscopy setup compatible with fluorescence-guided surgery
Development of a near-infrared Raman spectroscopy setup compatible with fluorescence-guided surgery Open
Combination of intraoperative wide-field fluorescence imaging and Raman spectroscopy aiding in tumor border identification.
View article: Early initiation of short‐term emollient use for the prevention of atopic dermatitis in high‐risk infants—The STOP‐AD randomised controlled trial
Early initiation of short‐term emollient use for the prevention of atopic dermatitis in high‐risk infants—The STOP‐AD randomised controlled trial Open
Background Protecting the skin barrier in early infancy may prevent atopic dermatitis (AD). We investigated if daily emollient use from birth to 2 months reduced AD incidence in high‐risk infants at 12 months. Methods This was a single‐cen…
View article: Monitoring dermal penetration and permeation kinetics of topical products; the role of Raman microspectroscopy
Monitoring dermal penetration and permeation kinetics of topical products; the role of Raman microspectroscopy Open
The study of human skin represents an important area of research and development in dermatology, toxicology, pharmacology and cosmetology, in order to assess the effects of exogenous agents, their interaction, their absorption mechanism, a…
View article: Early initiation of short-term emollient use for the prevention of atopic dermatitis in high risk infants -- the STOP AD randomised controlled trial
Early initiation of short-term emollient use for the prevention of atopic dermatitis in high risk infants -- the STOP AD randomised controlled trial Open
Background Protecting the skin barrier in early infancy may prevent atopic dermatitis (AD). We investigated if daily emollient use from birth to 2 months reduced AD incidence in high risk infants at 12 months. Methods This was a single-cen…
View article: Unmet Needs and Perspectives in Oral Cancer Prevention
Unmet Needs and Perspectives in Oral Cancer Prevention Open
Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associa…
View article: Natural moisturizing factor as a biomarker for filaggrin mutation status in a multi‐ethnic paediatric atopic dermatitis cohort
Natural moisturizing factor as a biomarker for filaggrin mutation status in a multi‐ethnic paediatric atopic dermatitis cohort Open
To the Editor, Atopic dermatitis (AD) is a common inflammatory skin disease among children with increasing prevalence in the past decades. The strongest and most widely replicated genetic risk factor for AD is a null mutation in the filagg…
View article: Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way Open
The goal of head and neck oncological surgery is complete tumor resection with adequate resection margins while preserving acceptable function and appearance. For oral cavity squamous cell carcinoma (OCSCC), different studies showed that o…
View article: Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way Open
The goal of head and neck oncological surgery is complete tumor resection with adequate resection margins while preserving acceptable function and appearance. For oral cavity squamous cell carcinoma (OCSCC), different studies showed that o…