Gesa Carstens
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View article: Longitudinal trends in the endemic symptomatic burden of COVID-19: Insights from community-based participatory virological surveillance in the Netherlands, November 2020-April 2025
Longitudinal trends in the endemic symptomatic burden of COVID-19: Insights from community-based participatory virological surveillance in the Netherlands, November 2020-April 2025 Open
The findings suggest that the clinical presentation of COVID-19 has evolved toward upper respiratory symptoms. Despite shifting symptoms, the impact on reported well-being in this population was remarkably stable, without a significantly l…
View article: Dutch participatory surveillance framework for evaluating evolutionary changes on SARS-CoV-2 affecting rapid diagnostic test sensitivity in 2022 − 2023
Dutch participatory surveillance framework for evaluating evolutionary changes on SARS-CoV-2 affecting rapid diagnostic test sensitivity in 2022 − 2023 Open
Evaluating RDT performance in the Dutch population and in-depth analysis of false-negative RDT specimens, led to no evidence for SARS-CoV-2 evolution affecting RDT sensitivity of the tests used. The participatory surveillance program Infec…
View article: Longitudinal trends in the endemic symptomatic burden of COVID-19: Insights from community-based participatory virological surveillance in the Netherlands, November 2020 - April 2025
Longitudinal trends in the endemic symptomatic burden of COVID-19: Insights from community-based participatory virological surveillance in the Netherlands, November 2020 - April 2025 Open
Objectives: To analyze changes over time in symptomatology and symptom burden of SARS-CoV-2 infected individuals. Methods: Data from symptomatic individuals from Infectieradar, an online community-based, participatory surveillance platform…
View article: Healthcare-seeking behavior and hidden influenza-like-illness across the COVID-19 pandemic: a multi-country participatory surveillance study
Healthcare-seeking behavior and hidden influenza-like-illness across the COVID-19 pandemic: a multi-country participatory surveillance study Open
Assessing healthcare seeking behavior is critical to estimate Influenza-like-illness (ILI) burden, i.e., the fraction of population infected, and inform vaccination campaigns for Influenza, SARS-CoV-2 and RSV, aimed at reducing disease cir…
View article: Flexible and scalable participatory syndromic and virological surveillance for respiratory infections: Our experiences in The Netherlands
Flexible and scalable participatory syndromic and virological surveillance for respiratory infections: Our experiences in The Netherlands Open
Background During the COVID-19 pandemic participatory digital surveillance of symptoms (syndromic surveillance) re-established itself as a worthy addition to the surveillance pyramid, as they are scalable, flexible and function independent…
View article: Pre-treatment untargeted cerebrospinal fluid metabolomic profiling in tuberculous meningitis uncovers pathways associated with mortality
Pre-treatment untargeted cerebrospinal fluid metabolomic profiling in tuberculous meningitis uncovers pathways associated with mortality Open
National Institute of Health; Wellcome Trust, UK.
View article: Co-infection dynamics of SARS-CoV-2 and respiratory viruses in the 2022/2023 respiratory season in the Netherlands
Co-infection dynamics of SARS-CoV-2 and respiratory viruses in the 2022/2023 respiratory season in the Netherlands Open
SARS-CoV-2 co-infections with rhinovirus, seasonal coronavirus, and adenovirus are frequently observed in the general population, but are not associated with more severe disease compared to SARS-CoV-2 mono-infections. Furthermore, we found…
View article: Dutch participatory surveillance framework for evaluating evolutionary changes on SARS-CoV-2 affecting Rapid Diagnostic Test sensitivity in 2022 - 2023.
Dutch participatory surveillance framework for evaluating evolutionary changes on SARS-CoV-2 affecting Rapid Diagnostic Test sensitivity in 2022 - 2023. Open
Background Rapid Diagnostic Tests (RDTs) have been pivotal in the diagnostics for SARS-CoV-2 and policies surrounding self-isolation. When self-testing policies are in place a decreased sensitivity of the virus to RDTs can give benefits fo…
View article: Co-infection dynamics of SARS-CoV-2 and respiratory viruses in the 2022/2023 respiratory season in the Netherlands
Co-infection dynamics of SARS-CoV-2 and respiratory viruses in the 2022/2023 respiratory season in the Netherlands Open
Objectives Evaluation of the presence and effect of SARS-CoV-2 co-infections on disease severity. Methods We collected both symptom data and nose- and throat samples from symptomatic people during the 2022/2023 respiratory season in a larg…
View article: Flexible and scalable participatory syndromic and virological surveillance for respiratory infections: our experiences in The Netherlands
Flexible and scalable participatory syndromic and virological surveillance for respiratory infections: our experiences in The Netherlands Open
Background During the COVID-19 pandemic participatory digital syndromic surveillance systems proved itself, as it is scalable, flexible and function independent from the health care system or health care seeking behaviour. A limitation of …
View article: Metabolite transport across central nervous system barriers
Metabolite transport across central nervous system barriers Open
Metabolomic analysis of cerebrospinal fluid (CSF) is used to improve diagnostics and pathophysiological understanding of neurological diseases. Alterations in CSF metabolite levels can partly be attributed to changes in brain metabolism, b…