Gesine Flehmig
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View article: Visceral fat mass dynamics in a 2‐year randomized STrength versus ENdurance training trial in people with obesity
Visceral fat mass dynamics in a 2‐year randomized STrength versus ENdurance training trial in people with obesity Open
Aim To compare the effectiveness of strength versus endurance training on reducing visceral fat in individuals with obesity. Materials and Methods For the STrength versus ENdurance (STEN) 24‐month randomized clinical trial, we assigned 239…
View article: Effect of Breastfeeding Duration on Coagulation in Women With and Without History of Gestational Diabetes Mellitus
Effect of Breastfeeding Duration on Coagulation in Women With and Without History of Gestational Diabetes Mellitus Open
Context Breastfeeding is associated with a reduced maternal risk for cardiovascular diseases (CVDs). Objective Since the underlying mechanisms are still poorly understood, we here examined the effect of breastfeeding on the plasmatic coagu…
View article: Leptin Improves Parameters of Brown Adipose Tissue Thermogenesis in Lipodystrophic Mice
Leptin Improves Parameters of Brown Adipose Tissue Thermogenesis in Lipodystrophic Mice Open
Lipodystrophy syndromes (LD) are a heterogeneous group of very rare congenital or acquired disorders characterized by a generalized or partial lack of adipose tissue. They are strongly associated with severe metabolic dysfunction due to ec…
View article: Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice
Nicotinamide Nucleotide Transhydrogenase (Nnt) is Related to Obesity in Mice Open
The C57BL/6J (B6J) mouse strain has been widely used as a control strain for the study of metabolic diseases and diet induced obesity (DIO). B6J mice carry a spontaneous deletion mutation in the nicotinamide nucleotide transhydrogenase (Nn…
View article: Effects of Weight Loss on Glutathione Peroxidase 3 Serum Concentrations and Adipose Tissue Expression in Human Obesity
Effects of Weight Loss on Glutathione Peroxidase 3 Serum Concentrations and Adipose Tissue Expression in Human Obesity Open
Background/Aims: Altered expression and circulating levels of glutathione peroxidase 3 (GPX3) have been observed in obesity and type 2 diabetes (T2D) across species. Here, we investigate whether GPX3 serum concentrations and adipose tissue…
View article: Fat depot‐specific expression of <i><scp>H</scp>OX<scp>C</scp>9</i> and <i><scp>H</scp>OX<scp>C</scp>10</i> may contribute to adverse fat distribution and related metabolic traits
Fat depot‐specific expression of <i><span>H</span>OX<span>C</span>9</i> and <i><span>H</span>OX<span>C</span>10</i> may contribute to adverse fat distribution and related metabolic traits Open
Objective Independent previous studies in both rodents and humans suggest a role of developmental genes in the origin of obesity and body fat distribution. Here, the hypothesis that human adipose tissue (AT) expression of the developmental…
View article: Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue
Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue Open
Weight loss has been shown to significantly improve Adipose tissue (AT) function, however changes in AT gene expression profiles particularly in visceral AT (VAT) have not been systematically studied. Here, we tested the hypothesis that ex…