Ghadeer K. Dawwas
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View article: Weight loss from glucagon-like peptide-1 receptor agonists by genetic factors in adults with type 2 diabetes
Weight loss from glucagon-like peptide-1 receptor agonists by genetic factors in adults with type 2 diabetes Open
View article: Bleeding and Thrombotic Outcomes in Patients With Inflammatory Bowel Disease and Venous Thromboembolism
Bleeding and Thrombotic Outcomes in Patients With Inflammatory Bowel Disease and Venous Thromboembolism Open
Patients with inflammatory bowel disease [IBD] are at an increased risk of venous thromboembolism [VTE] and bleeding. While oral anticoagulants are effective in preventing VTE recurrence, concerns exist regarding the risk of bleeding compl…
View article: Multi-ancestry genome-wide and transcriptome-wide association analyses identified new risk loci and genes for inflammatory bowel disease
Multi-ancestry genome-wide and transcriptome-wide association analyses identified new risk loci and genes for inflammatory bowel disease Open
To advance genetic understanding of inflammatory bowel disease (IBD), we conducted genome-wide association meta-analyses of 63,415 IBD cases of European and East Asian descendants and identified 90 previously unknown risk loci. Integrating…
View article: Shifting obesity treatment paradigms: Trends of glucagon‐like peptide‐1 receptor agonists and bariatric surgery in the United States
Shifting obesity treatment paradigms: Trends of glucagon‐like peptide‐1 receptor agonists and bariatric surgery in the United States Open
View article: Incidence, Prevalence, and Racial and Ethnic Distribution of Inflammatory Bowel Disease in the United States
Incidence, Prevalence, and Racial and Ethnic Distribution of Inflammatory Bowel Disease in the United States Open
View article: Direct Oral Anticoagulants Compared With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease Without Mechanical Valves
Direct Oral Anticoagulants Compared With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease Without Mechanical Valves Open
Background Despite proven efficacy and safety of direct oral anticoagulants (DOACs) over warfarin in patients with atrial fibrillation (AF), data on patients with AF and valvular heart disease remain scarce. We aimed to evaluate the DOACs …
View article: Comparative effectiveness and safety of rivaroxaban with other oral anticoagulants in older adults with nonvalvular atrial fibrillation: population-based analysis in response to updated Beers Criteria
Comparative effectiveness and safety of rivaroxaban with other oral anticoagulants in older adults with nonvalvular atrial fibrillation: population-based analysis in response to updated Beers Criteria Open
View article: The Clinical Course of Bowel Urgency Severity Among Patients with Inflammatory Bowel Disease—A Real-World Study
The Clinical Course of Bowel Urgency Severity Among Patients with Inflammatory Bowel Disease—A Real-World Study Open
View article: Skeletal Muscle Relaxant Drug-Drug-Drug Interactions and Unintentional Traumatic Injury: Screening to Detect Three-Way Drug Interaction Signals
Skeletal Muscle Relaxant Drug-Drug-Drug Interactions and Unintentional Traumatic Injury: Screening to Detect Three-Way Drug Interaction Signals Open
Background and Purpose. Skeletal muscle relaxants (SMRs) are commonly co-prescribed with potentially interacting medications that may contribute to increased risk of unintentional traumatic injury (hereafter, injury). While prior research …
View article: Effectiveness and safety of prophylactic anticoagulation among hospitalized patients with inflammatory bowel disease
Effectiveness and safety of prophylactic anticoagulation among hospitalized patients with inflammatory bowel disease Open
Hospitalized patients with inflammatory bowel disease (IBD) are at increased risk of venous thromboembolism (VTE). We aimed to evaluate the effectiveness and safety of prophylactic anticoagulation compared with no anticoagulation in hospit…
View article: Incidence, Prevalence, and Racial and Ethnic Distribution of Inflammatory Bowel Disease in the United States
Incidence, Prevalence, and Racial and Ethnic Distribution of Inflammatory Bowel Disease in the United States Open
View article: Development and Validation of Claims-Based Definitions to Identify Incident and Prevalent Inflammatory Bowel Disease in Administrative Healthcare Databases
Development and Validation of Claims-Based Definitions to Identify Incident and Prevalent Inflammatory Bowel Disease in Administrative Healthcare Databases Open
Background To facilitate inflammatory bowel disease (IBD) research in the United States, we developed and validated claims-based definitions to identify incident and prevalent IBD diagnoses using administrative healthcare claims data among…
View article: Apixaban Versus Rivaroxaban in Patients With Atrial Fibrillation and Valvular Heart Disease
Apixaban Versus Rivaroxaban in Patients With Atrial Fibrillation and Valvular Heart Disease Open
National Institutes of Health.
View article: Population-based screening to detect benzodiazepine drug-drug-drug interaction signals associated with unintentional traumatic injury
Population-based screening to detect benzodiazepine drug-drug-drug interaction signals associated with unintentional traumatic injury Open
View article: Trends in post-discharge prophylactic anticoagulant use among stroke patients in the United States between 2006 and 2019
Trends in post-discharge prophylactic anticoagulant use among stroke patients in the United States between 2006 and 2019 Open
In this population-based study of stroke patients, we found that post-discharge anticoagulant use remains low through 2019. Prophylactic use of heparin or rivaroxaban was relatively low but the use of apixaban increased over the study peri…
View article: Identifying Clinically Relevant Drug–Drug Interactions With Methadone and Buprenorphine: A Translational Approach to Signal Detection
Identifying Clinically Relevant Drug–Drug Interactions With Methadone and Buprenorphine: A Translational Approach to Signal Detection Open
Methadone and buprenorphine have pharmacologic properties that are concerning for a high risk of drug–drug interactions (DDIs). We performed high‐throughput screening for clinically relevant DDIs with methadone or buprenorphine by combinin…
View article: Skeletal muscle relaxant drug–drug–drug interactions and unintentional traumatic injury: Screening to detect three‐way drug interaction signals
Skeletal muscle relaxant drug–drug–drug interactions and unintentional traumatic injury: Screening to detect three‐way drug interaction signals Open
Aim The aim of this study was to identify skeletal muscle relaxant (SMR) drug–drug–drug interaction (3DI) signals associated with increased rates of unintentional traumatic injury. Methods We conducted automated high‐throughput pharmacoepi…
View article: Outcomes of Direct Oral Anticoagulants in Patients with Atrial Fibrillation and Valvular Heart Disease
Outcomes of Direct Oral Anticoagulants in Patients with Atrial Fibrillation and Valvular Heart Disease Open
View article: Signals of Muscle Relaxant Drug Interactions Associated with Unintentional Traumatic Injury: A Population-Based Screening Study
Signals of Muscle Relaxant Drug Interactions Associated with Unintentional Traumatic Injury: A Population-Based Screening Study Open
View article: Apixaban has superior effectiveness and safety compared to rivaroxaban in patients with commercial healthcare coverage: A population‐based analysis in response to <scp>CVS</scp> 2022 formulary changes
Apixaban has superior effectiveness and safety compared to rivaroxaban in patients with commercial healthcare coverage: A population‐based analysis in response to <span>CVS</span> 2022 formulary changes Open
Peer Reviewed
View article: Comparative Safety of Sodium–Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase 4 Inhibitors and Sulfonylureas on the Risk of Diabetic Ketoacidosis
Comparative Safety of Sodium–Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase 4 Inhibitors and Sulfonylureas on the Risk of Diabetic Ketoacidosis Open
OBJECTIVE To assess the association of sodium–glucose cotransporter 2 (SGLT2) inhibitors with diabetic ketoacidosis compared with dipeptidyl peptidase 4 (DPP-4) inhibitors and sulfonylureas in patients with type 2 diabetes. RESEARCH DESIGN…
View article: Comparative Safety of Sodium–Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase 4 Inhibitors and Sulfonylureas on the Risk of Diabetic Ketoacidosis
Comparative Safety of Sodium–Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase 4 Inhibitors and Sulfonylureas on the Risk of Diabetic Ketoacidosis Open
Objective: To assess the association of sodium-glucose co-transporter-2 (SGLT2) inhibitors with diabetic ketoacidosis compared to dipeptidyl peptidase-4 (DPP4) inhibitors and sulfonylureas in patients with type 2 diabetes. Resear…
View article: Comparative Safety of Sodium–Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase 4 Inhibitors and Sulfonylureas on the Risk of Diabetic Ketoacidosis
Comparative Safety of Sodium–Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase 4 Inhibitors and Sulfonylureas on the Risk of Diabetic Ketoacidosis Open
Objective: To assess the association of sodium-glucose co-transporter-2 (SGLT2) inhibitors with diabetic ketoacidosis compared to dipeptidyl peptidase-4 (DPP4) inhibitors and sulfonylureas in patients with type 2 diabetes. Resear…
View article: Comparative Safety of Dipeptidyl Peptidase‐4 Inhibitors and Sudden Cardiac Arrest and Ventricular Arrhythmia: Population‐Based Cohort Studies
Comparative Safety of Dipeptidyl Peptidase‐4 Inhibitors and Sudden Cardiac Arrest and Ventricular Arrhythmia: Population‐Based Cohort Studies Open
In vivo studies suggest that arrhythmia risk may be greater with less selective dipeptidyl peptidase‐4 inhibitors, but evidence from population‐based studies is missing. We aimed to compare saxagliptin, sitagliptin, and linagliptin with re…
View article: Prevalence and Factors Associated With Fecal Urgency Among Patients With Ulcerative Colitis and Crohn’s Disease in the Study of a Prospective Adult Research Cohort With Inflammatory Bowel Disease
Prevalence and Factors Associated With Fecal Urgency Among Patients With Ulcerative Colitis and Crohn’s Disease in the Study of a Prospective Adult Research Cohort With Inflammatory Bowel Disease Open
Background In patients with ulcerative colitis (UC) and Crohn’s disease (CD), this research examined the following: prevalence of fecal urgency (hereafter urgency), association of urgency with inflammatory bowel disease (IBD) symptoms and …
View article: Compared to commercially insured patients, Medicare advantage patients adopt newer diabetes drugs more slowly and adhere to them less
Compared to commercially insured patients, Medicare advantage patients adopt newer diabetes drugs more slowly and adhere to them less Open
Aims To compare rates of use and adherence for newer versus older second‐line diabetes drug classes in commercially insured, Medicare Advantage and dual‐eligible (covered by both Medicare and Medicaid) patients. Materials and Methods Longi…
View article: Population‐Based Signals of Antidepressant Drug Interactions Associated With Unintentional Traumatic Injury
Population‐Based Signals of Antidepressant Drug Interactions Associated With Unintentional Traumatic Injury Open
Antidepressants are very widely used and associated with traumatic injury, yet little is known about their potential for harmful drug interactions. We aimed to identify potential drug interaction signals by assessing concomitant medication…
View article: The Impact of Introducing Patient-Reported Inflammatory Bowel Disease Symptoms via Electronic Survey on Clinic Visit Length, Patient and Provider Satisfaction, and the Environment Microbiome
The Impact of Introducing Patient-Reported Inflammatory Bowel Disease Symptoms via Electronic Survey on Clinic Visit Length, Patient and Provider Satisfaction, and the Environment Microbiome Open
Electronic health records have the potential to improve patient care while reducing the burden of documentation on clinicians. Smartforms are tools for standardized data collection within the Epic electronic health record. We developed an …
View article: Long-term Outcomes Following Multiply Recurrent Clostridioides difficile Infection and Fecal Microbiota Transplantation
Long-term Outcomes Following Multiply Recurrent Clostridioides difficile Infection and Fecal Microbiota Transplantation Open
View article: Table of Contents
Table of Contents Open