Ghaleb A. Husseini
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View article: The Emerging Role of MXenes in Cancer Treatment
The Emerging Role of MXenes in Cancer Treatment Open
MXenes are relatively new 2D materials made up of carbides and/or nitrides of transition metals with a chemical formula Mn+1XnTx. They are usually fabricated by chemically etching a ceramic phase. MXenes possess tunable catalytic, optical,…
View article: A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy
A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy Open
By 2030, millions of new cancer cases will be diagnosed, as well as millions of cancer-related deaths. Traditional drug delivery methods have limitations, so developing smart drug delivery systems (SDDs) has emerged as a promising avenue f…
View article: Microfluidic Electrochemical Desalination Systems: A Review
Microfluidic Electrochemical Desalination Systems: A Review Open
Microfluidic techniques have emerged as promising, efficient, cost-effective, and environmentally friendly desalination solutions. By utilizing fluid dynamics at the microscale, these techniques offer precise control over chemical, biologi…
View article: A Review of Acetone Vapor Sensors for Non-Invasive Diabetes Diagnosis and Management: Technologies, Challenges, and Future Directions
A Review of Acetone Vapor Sensors for Non-Invasive Diabetes Diagnosis and Management: Technologies, Challenges, and Future Directions Open
DM is a chronic metabolic disorder characterized by insufficient insulin production or impaired use in the cells, leading to a high blood glucose level. This disease requires constant monitoring of blood glucose levels. Traditional blood g…
View article: A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model
A Variational Bayesian-Based Correntropy Cubature Kalman Filter for Drug Release Estimation Using a Second-Order Model Open
Ultrasound-triggered liposomes designed for specific targeting show promise as a drug delivery system, with the potential to enhance the effectiveness of chemotherapy while minimizing related side effects in clinical settings. This paper a…
View article: Nanocarriers Responsive to Light—A Review
Nanocarriers Responsive to Light—A Review Open
The non-specific and minimally selective nature of traditional drug administration methods, along with various other limitations, makes the use of drug delivery systems more favorable. Light-responsive, or light-triggered, drug delivery sy…
View article: Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures
Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures Open
As load-bearing components, metallic implants are frequently used for orthopedic prostheses due to their superiority over conventional ceramic and polymeric biomaterials. Metal-based orthopedic implants have been subjected to various fabri…
View article: AI-Aided Robotic Wide-Range Water Quality Monitoring System
AI-Aided Robotic Wide-Range Water Quality Monitoring System Open
Waterborne illnesses lead to millions of fatalities worldwide each year, particularly in developing nations. In this paper, we introduce a comprehensive system designed for the autonomous early detection of viral outbreaks transmitted thro…
View article: Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review
Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review Open
Conventional cancer chemotherapy often struggles with safely and effectively delivering anticancer therapeutics to target tissues, frequently leading to dose-limiting toxicity and suboptimal therapeutic outcomes. This has created a need fo…
View article: Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy
Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy Open
The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review of the …
View article: Targeted Cancer Therapy‐on‐A‐Chip
Targeted Cancer Therapy‐on‐A‐Chip Open
Targeted cancer therapy (TCT) is gaining increased interest because it reduces the risks of adverse side effects by specifically treating tumor cells. TCT testing has traditionally been performed using two‐dimensional (2D) cell culture and…
View article: Deep Learning for the Accurate Prediction of Triggered Drug Delivery
Deep Learning for the Accurate Prediction of Triggered Drug Delivery Open
The need to mitigate the adverse effects of chemotherapy has driven the exploration of innovative drug delivery approaches. One emerging trend in cancer treatment is the utilization of Drug Delivery Systems (DDSs), facilitated by nanotechn…
View article: Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin
Microwave-Responsive Metal-Organic Frameworks (MOFs) for Enhanced In Vitro Controlled Release of Doxorubicin Open
Metal-organic frameworks (MOFs) are excellent candidates for a range of applications because of their numerous advantages, such as high surface area, porosity, and thermal and chemical stability. In this study, microwave (MW) irradiation i…
View article: Recent Advancements in Bone Tissue Engineering: Integrating Smart Scaffold Technologies and Bio-Responsive Systems for Enhanced Regeneration
Recent Advancements in Bone Tissue Engineering: Integrating Smart Scaffold Technologies and Bio-Responsive Systems for Enhanced Regeneration Open
In exploring the challenges of bone repair and regeneration, this review evaluates the potential of bone tissue engineering (BTE) as a viable alternative to traditional methods, such as autografts and allografts. Key developments in biomat…
View article: Enhancing Curcumin’s therapeutic potential in cancer treatment through ultrasound mediated liposomal delivery
Enhancing Curcumin’s therapeutic potential in cancer treatment through ultrasound mediated liposomal delivery Open
Improving the efficacy of chemotherapy remains a key challenge in cancer treatment, considering the low bioavailability, high cytotoxicity, and undesirable side effects of some clinical drugs. Targeted delivery and sustained release of the…
View article: Modeling of brain tumors using in vitro, in vivo, and microfluidic models: A review of the current developments
Modeling of brain tumors using in vitro, in vivo, and microfluidic models: A review of the current developments Open
Brain cancers are some of the most complex diseases to treat, despite the numerous advances science has made in cancer chemotherapy and research. One of the key obstacles to identifying potential cures for this disease is the difficulty in…
View article: State-of-All-the-Art and Prospective Hydrogel-Based Transdermal Drug Delivery Systems
State-of-All-the-Art and Prospective Hydrogel-Based Transdermal Drug Delivery Systems Open
Over the past few decades, notable advancements have been made in the field of transdermal drug delivery systems (TDDSs), presenting a promising alternative to conventional oral drug administration. This comprehensive review aims to enhanc…
View article: Production of Targeted Estrone Liposomes Using a Herringbone Micromixer
Production of Targeted Estrone Liposomes Using a Herringbone Micromixer Open
Liposomes are spherical vesicles formed from bilayer lipid membranes that are extensively used in targeted drug delivery as nanocarriers to deliver therapeutic reagents to specific tissues and organs in the body. Recently, we have reported…
View article: Encapsulation and release of calcein from herceptin-conjugated eLiposomes
Encapsulation and release of calcein from herceptin-conjugated eLiposomes Open
Achieving an optimal therapeutic level is crucial in effectively eradicating cancer cells during treatment. However, conventional chemotherapy-associated systemic administration of anticancer agents leads to many side effects. To achieve t…
View article: Support vector regression (SVR) for prediction of ultrasound drug release
Support vector regression (SVR) for prediction of ultrasound drug release Open
Over the last decade, increasing interest in drug delivery systems (DDS) has been directed toward the application of machine learning (ML), a sub-field of artificial intelligence (AI), for analyzing and predicting drug release profiles and…
View article: Predicting Calcein Release from Ultrasound-Targeted Liposomes: A Comparative Analysis of Random Forest and Support Vector Machine
Predicting Calcein Release from Ultrasound-Targeted Liposomes: A Comparative Analysis of Random Forest and Support Vector Machine Open
The type of algorithm employed to predict drug release from liposomes plays an important role in affecting the accuracy. In recent years, Machine Learning (ML) has shown potential for modeling complex drug delivery systems and predicting d…
View article: Advances in liposomal nanotechnology: from concept to clinics
Advances in liposomal nanotechnology: from concept to clinics Open
A schematic diagram of a liposome's structure, highlighting its lipid bilayer. The illustration shows drug molecules encapsulated within the core or between phospholipid layers, offering insight into the liposome's role in drug delivery sy…
View article: Digital Twins of Biological Systems: A Narrative Review
Digital Twins of Biological Systems: A Narrative Review Open
The concept of Digital Twins (DTs), software models that mimic the behavior and interactions of physical or conceptual objects within their environments, has gained traction in recent years, particularly in medicine and healthcare research…
View article: Biodegradable Magnesium Alloys for Biomedical Implants: Properties, Challenges, and Surface Modifications with a Focus on Orthopedic Fixation Repair
Biodegradable Magnesium Alloys for Biomedical Implants: Properties, Challenges, and Surface Modifications with a Focus on Orthopedic Fixation Repair Open
Biomedical devices made from high-modulus and hardness materials play a critical role in enhancing the quality of life for people with bone-related ailments. While these materials have been successfully used in orthopedic applications, con…
View article: Encapsulation and release of calcein from Herceptin- conjugated eLiposomes
Encapsulation and release of calcein from Herceptin- conjugated eLiposomes Open
Achieving an optimal therapeutic level is crucial in effectively eradicating cancer cells during treatment. However, conventional chemotherapy-associated systemic administration of anticancer agents leads to many side effects. To achieve t…
View article: Exploring the Potential of High-Frequency Ultrasound to Enhance Liposomal Curcumin Delivery to HCC 1954 Breast Cancer Cells: A Promising Strategy for Harnessing the Therapeutic Potential of Curcumin in Cancer Treatment
Exploring the Potential of High-Frequency Ultrasound to Enhance Liposomal Curcumin Delivery to HCC 1954 Breast Cancer Cells: A Promising Strategy for Harnessing the Therapeutic Potential of Curcumin in Cancer Treatment Open
Improving the efficacy of chemotherapy remains a key challenge in cancer treatment, considering the low bioavailability, high cytotoxicity, and undesirable side effects of some clinical drugs. Targeted delivery and sustained release of the…
View article: Impact of Ionic Strength and Charge Density on Donnan Potential in the NaCl-Cation Exchange Membrane System
Impact of Ionic Strength and Charge Density on Donnan Potential in the NaCl-Cation Exchange Membrane System Open
This work aims to theoretically investigate the effect of both the fixed charge density of ion exchange membranes and the ionic strength of the treated aqueous NaCl solution on the generated Donnan potential at thermodynamic equilibrium co…
View article: Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy
Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy Open
The low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in addition, the surgical resection of bone tumors can cause significant bone defects, further hindering the effective treatment of the disease. 3D prin…