Keyur Patel
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View article: Machine learning models using non-invasive tests & B-mode ultrasound to predict liver-related outcomes in metabolic dysfunction-associated steatotic liver disease
Machine learning models using non-invasive tests & B-mode ultrasound to predict liver-related outcomes in metabolic dysfunction-associated steatotic liver disease Open
Advanced metabolic-dysfunction-associated steatotic liver disease (MASLD) fibrosis (F3-4) predicts liver-related outcomes. Serum and elastography-based non-invasive tests (NIT) cannot yet reliably predict MASLD outcomes. The role of B-mode…
View article: Cerebellum metastasis model of HER2-positive breast cancer unveils key role of IL34-induced Arg1+ macrophages
Cerebellum metastasis model of HER2-positive breast cancer unveils key role of IL34-induced Arg1+ macrophages Open
SUMMARY Brain metastases occur in up to 40% of Stage IV breast cancer patients. The cerebellum is a frequent location for metastases in HER2-positive breast cancer patients, but the mechanisms for this are unknown. Here, we developed a syn…
View article: Characterizing the Representation of Different Global Regions and National Income-Levels Amongst Invited Speakers and Committee Members at Major International Spine Surgery Conferences
Characterizing the Representation of Different Global Regions and National Income-Levels Amongst Invited Speakers and Committee Members at Major International Spine Surgery Conferences Open
Study Design Observational study. Objective To evaluate representation of countries and gross national income (GNI) at major international spine conferences. Methods The 50 most attended spine conferences were identified via ChatGPT. Confe…
View article: Association of Metabolic Comorbidities With Fibrosis Severity and Fibrosis Regression in Patients With Chronic Hepatitis B
Association of Metabolic Comorbidities With Fibrosis Severity and Fibrosis Regression in Patients With Chronic Hepatitis B Open
Presence of metabolic comorbidities in untreated CHB patients is associated with more severe liver fibrosis and, after initiation of antiviral therapy, with less fibrosis regression and a higher risk of fibrosis progression.
View article: Discrete choice experiments and conjoint analyses in health screening programs for type 2 diabetes and liver disease: a scoping review
Discrete choice experiments and conjoint analyses in health screening programs for type 2 diabetes and liver disease: a scoping review Open
Background: We aimed to summarize the evidence on the use of discrete choice experiments (DCEs) and conjoint analyses to quantify stakeholders’ preferences for screening programs for type 2 diabetes (T2D) and liver diseases, with a specifi…
View article: Genomic medicine and personalized treatment: a narrative review
Genomic medicine and personalized treatment: a narrative review Open
Genomic medicine, which integrates genomics and bioinformatics into clinical care and diagnostics, is transforming healthcare by enabling personalized treatment approaches. Advances in technologies such as DNA sequencing, proteomics, and c…
View article: Examining the prevalence of hepatic steatosis and advanced fibrosis using non-invasive measures across Canada: A national estimate using the Canadian Health Measures Survey (CHMS) from 2009-2019
Examining the prevalence of hepatic steatosis and advanced fibrosis using non-invasive measures across Canada: A national estimate using the Canadian Health Measures Survey (CHMS) from 2009-2019 Open
We estimate between 1 in 3 and 1 in 2 adults have hepatic steatosis, and 195,000-406,200 are at high risk of advanced liver fibrosis in Canada. No routine screening guidelines for liver fibrosis exist in Canada, and most patients are unawa…
View article: Risk Management in Residential Projects
Risk Management in Residential Projects Open
The construction industry faces numerous risks, particularly in residential projects with significant complexity and scale of operations. Effective risk management in these projects is critical to ensuring successful outcomes. This study f…
View article: Non-Invasive Assessment of Liver Fibrosis in Hepatitis B Patients
Non-Invasive Assessment of Liver Fibrosis in Hepatitis B Patients Open
The aim of this review is to provide updated information on the clinical use of non-invasive serum and imaging-based tests for fibrosis assessment in chronic hepatitis B (CHB) virus infection. In recent years, non-invasive tests (NIT) have…
View article: Acyl‐CoA Thioesterase 1 Contributes to Transition of Steatosis to Metabolic‐Associated Steatohepatitis
Acyl‐CoA Thioesterase 1 Contributes to Transition of Steatosis to Metabolic‐Associated Steatohepatitis Open
Background . Metabolic dysfunction‐associated steatohepatitis (MASH) has become the leading cause of chronic liver disease, but there has been no approved pharmacotherapy to date. Methods . We used a network analysis approach to delineate …
View article: Assessing Treatment Efficacy and Determinants of Outcome in Isoniazid Mono-resistant Tuberculosis Patients: A Prospective Observational Study in Gujarat
Assessing Treatment Efficacy and Determinants of Outcome in Isoniazid Mono-resistant Tuberculosis Patients: A Prospective Observational Study in Gujarat Open
Introduction: There is a high number of isoniazid-resistant tuberculosis (TB) in India; estimates imply that over 25% of TB patients there are isoniazid-resistant. Hence, the study aimed to evaluate the effectiveness of therapy for patient…
View article: Correction: Clinical outcomes in patients with complicated appendicitis
Correction: Clinical outcomes in patients with complicated appendicitis Open
View article: Correlation of Body Mass Index (BMI) with Saliva and Blood Glucose Levels in Diabetic and Non-Diabetic Patients
Correlation of Body Mass Index (BMI) with Saliva and Blood Glucose Levels in Diabetic and Non-Diabetic Patients Open
A BSTRACT Background: To compare and correlate the relationship between body mass index (BMI) and blood and salivary glucose (mean values) in patients with diabetes and non-diabetic control group patients. Materials and Methods: In the stu…
View article: Tumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapy
Tumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapy Open
View article: The Effects of Obesity and Diabetes on the Pediatric Population
The Effects of Obesity and Diabetes on the Pediatric Population Open
The World Health Organization has declared diabetes (DM) and Obesity to be epidemics due to their rising prevalence. Obesity plays a role in the aetiopathogenesis of type 2 diabetes, the most common type of diabetes in the world, as well a…
View article: PRO-C3 is a predictor of clinical outcomes in distinct cohorts of patients with advanced liver disease
PRO-C3 is a predictor of clinical outcomes in distinct cohorts of patients with advanced liver disease Open
View article: Randomized Trial of Tenofovir With or Without Peginterferon Alfa Followed by Protocolized Treatment Withdrawal in Adults With Chronic Hepatitis B
Randomized Trial of Tenofovir With or Without Peginterferon Alfa Followed by Protocolized Treatment Withdrawal in Adults With Chronic Hepatitis B Open
INTRODUCTION: Hepatitis B surface antigen (HBsAg) loss is associated with improved long-term outcomes of patients with chronic hepatitis B but is infrequently achieved with current monotherapies. We assessed whether combination strategies …
View article: Management of Severe, Steroid-Resistant and Steroid-Refractory Hepatotoxicity in Patients Treated with Checkpoint Inhibitor Immunotherapy
Management of Severe, Steroid-Resistant and Steroid-Refractory Hepatotoxicity in Patients Treated with Checkpoint Inhibitor Immunotherapy Open
View article: Reduced Rates of Post-Transplant Recurrent Hepatocellular Carcinoma in Non-Alcoholic Steatohepatitis: A Propensity Score Matched Analysis
Reduced Rates of Post-Transplant Recurrent Hepatocellular Carcinoma in Non-Alcoholic Steatohepatitis: A Propensity Score Matched Analysis Open
Non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) has become the second leading cause of HCC-related liver transplantation in the United States. This study investigated post-transplant recurrence and survival for …
View article: Predictors of patient survival following liver transplant in non-alcoholic steatohepatitis: A systematic review and meta-analysis
Predictors of patient survival following liver transplant in non-alcoholic steatohepatitis: A systematic review and meta-analysis Open
View article: IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH Open
Background and Aims: Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood. Our aim was to evaluate serum IL‐31 as a putative biomarker of pruritus in cl…
View article: An <scp>MMP</scp>‐degraded and cross‐linked fragment of type <scp>III</scp> collagen as a non‐invasive biomarker of hepatic fibrosis resolution
An <span>MMP</span>‐degraded and cross‐linked fragment of type <span>III</span> collagen as a non‐invasive biomarker of hepatic fibrosis resolution Open
Background and Aims Liver fibrosis results from a prolonged wound healing response to continued injury with excessive production of extracellular proteins. In patients with chronic liver disease, the monitoring of liver fibrosis dynamics i…
View article: Development and validation of an ensemble machine learning framework for detection of all-cause advanced hepatic fibrosis: a retrospective cohort study
Development and validation of an ensemble machine learning framework for detection of all-cause advanced hepatic fibrosis: a retrospective cohort study Open
Toronto General Hospital Foundation.
View article: A220 THE IMPACT OF DIABETES AND AGE ON PERFORMANCE OF NON-INVASIVE SERUM-BASED TESTS FOR PREDICTION OF ADVANCED FIBROSIS IN BIOPSY-PROVEN NAFLD
A220 THE IMPACT OF DIABETES AND AGE ON PERFORMANCE OF NON-INVASIVE SERUM-BASED TESTS FOR PREDICTION OF ADVANCED FIBROSIS IN BIOPSY-PROVEN NAFLD Open
Background Non-alcoholic fatty liver disease (NAFLD) is now a leading cause of end-stage liver disease. Advanced stage F3-4 fibrosis predicts liver-related mortality in NAFLD patients. Simple non-invasive serum-based tests (NIT) for F3-4 a…
View article: Machine Learning Approach to Classify Cardiovascular Disease in Patients With Nonalcoholic Fatty Liver Disease in the UK Biobank Cohort
Machine Learning Approach to Classify Cardiovascular Disease in Patients With Nonalcoholic Fatty Liver Disease in the UK Biobank Cohort Open
Background Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. Cardiovascular disease (CVD) is the leading cause of mortality among patients with NAFLD. The aim of our study was to develop a machine lear…
View article: Current considerations for clinical management and care of non-alcoholic fatty liver disease: Insights from the 1st International Workshop of the Canadian NASH Network (CanNASH)
Current considerations for clinical management and care of non-alcoholic fatty liver disease: Insights from the 1st International Workshop of the Canadian NASH Network (CanNASH) Open
Non-alcoholic fatty liver disease (NAFLD) affects approximately 8 million Canadians. NAFLD refers to a disease spectrum ranging from bland steatosis to non-alcoholic steatohepatitis (NASH). Nearly 25% of patients with NAFLD develop NASH, w…
View article: Combination of FIB-4 with ultrasound surface nodularity or elastography as predictors of histologic advanced liver fibrosis in chronic liver disease
Combination of FIB-4 with ultrasound surface nodularity or elastography as predictors of histologic advanced liver fibrosis in chronic liver disease Open
View article: Metabolic dysfunction-associated fatty liver disease increases risk of adverse outcomes in patients with chronic hepatitis B
Metabolic dysfunction-associated fatty liver disease increases risk of adverse outcomes in patients with chronic hepatitis B Open
View article: Liver disease symptoms are associated with higher risk of adverse clinical outcomes: A longitudinal study of North American adults with chronic Hepatitis B
Liver disease symptoms are associated with higher risk of adverse clinical outcomes: A longitudinal study of North American adults with chronic Hepatitis B Open
In this large cohort of CHB patients, symptoms were generally mild and stable over time. However, in some patients with moderate symptoms at baseline, deleterious clinical outcomes were more frequent in follow-up.
View article: Simultaneous liver kidney allocation policy and the Safety Net: an early examination of utilization and outcomes in the United States
Simultaneous liver kidney allocation policy and the Safety Net: an early examination of utilization and outcomes in the United States Open
Rates of simultaneous liver kidney (SLK) transplantation in the United States have progressively risen. On 8/10/17, the Organ Procurement and Transplantation Network implemented a policy defining criteria for SLK, with a “Safety Net” to pr…