Ghasem Mosayebi
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View article: In vitro Evaluation of the Combined Effects of a Static Magnetic Field and Curcumin on MCF7 and HeLa Cell Lines
In vitro Evaluation of the Combined Effects of a Static Magnetic Field and Curcumin on MCF7 and HeLa Cell Lines Open
This study demonstrated that SMF exposure significantly increased necrotic cell death in HeLa cells and accelerated apoptosis in both cancer cell types. The minimum effective dose of curcumin combined with SMF caused a four-fold increase i…
View article: Preparation of Nanoliposomes Containing Rosemary Alcoholic Extract with Polyethylene Glycol Coating
Preparation of Nanoliposomes Containing Rosemary Alcoholic Extract with Polyethylene Glycol Coating Open
View article: The effect of vitamin D and vitamin A supplementation on T cell levels of patients with pneumosepsis: A double-blind, randomized clinical trial
The effect of vitamin D and vitamin A supplementation on T cell levels of patients with pneumosepsis: A double-blind, randomized clinical trial Open
Summary: Background & aims: Pneumosepsis is a global healthcare challenge associated with substantial morbidity and mortality rates. Its pathogenesis involves intricate interactions among host factors, pathogens, and immune dysregulation. …
View article: Pattern of Interleukin-17A and Interleukin-1β in Migraine Patients
Pattern of Interleukin-17A and Interleukin-1β in Migraine Patients Open
Background: Migraine is a complex neurological disorder. The precise etiology of migraine is not clear. Many studies have been conducted on the association of the immune system with migraine pathophysiology. Neurogenic inflammation, the ma…
View article: Effect of Opium and Related Detoxification Drugs on RAW 264.7 Macrophages
Effect of Opium and Related Detoxification Drugs on RAW 264.7 Macrophages Open
Introduction: Detoxification drugs used for opium (OPM) withdrawal, such as buprenorphine (BUP), naltrexone (NTX), and methadone (MTD), can have inhibitory effects. In a recent study, the impact of OPM and these detoxification drugs on cyt…
View article: Increase in TGF-β and CD4+CD25+Regulatory T Cells in Iranian Patients With Type 2 Diabetes :A Case– Control Study
Increase in TGF-β and CD4+CD25+Regulatory T Cells in Iranian Patients With Type 2 Diabetes :A Case– Control Study Open
Background: Patients with type 2 diabetes mellitus (T2DM) often have imbalance in inflammatory cells, increased inflammatory cytokines, and defects in homeostasis. The present study aimed to evaluate the percentage of Treg cells, lymphocyt…
View article: Expression and Alteration Value of Long Noncoding RNA AB073614 and FER1L4 in Patients with Acute Myeloid Leukemia (AML)
Expression and Alteration Value of Long Noncoding RNA AB073614 and FER1L4 in Patients with Acute Myeloid Leukemia (AML) Open
The present study indicates that AB073614 and FER1L4 might serve as prognosis biomarkers in AML patients. However, further detailed examinations in this field are warranted. It is proposed that the likely mechanism of imbalanced PI3K and P…
View article: Chamomile and Urtica dioica extracts improve immunological and histological alterations associated with polycystic ovarian syndrome in DHEA -induced mice
Chamomile and Urtica dioica extracts improve immunological and histological alterations associated with polycystic ovarian syndrome in DHEA -induced mice Open
Background One of the novel mechanisms in the pathogenesis of Polycystic ovary syndrome (PCOS) is low-grade chronic inflammation. Chamomile (Matricaria recutita L.) and Nettle (Urtica dioica), with phytoestrogenic and antioxidant propertie…
View article: rs3761548 (C/A) and rs5902434 (del/ATT) polymorphisms of Foxp3 gene in Iranian patients with migraine
rs3761548 (C/A) and rs5902434 (del/ATT) polymorphisms of Foxp3 gene in Iranian patients with migraine Open
Background Migraine is a neurovascular disorder; several studies have demonstrated the immune system plays a key role in migraine pathogenesis . The aim of this study was to investigate the association between FOXP3 gene polymorphism and s…
View article: Evaluation of Tcell exhaustion based on the expression of EOMES, Tbet and co-inhibitory receptors in severe and non-severe covid-19 patients
Evaluation of Tcell exhaustion based on the expression of EOMES, Tbet and co-inhibitory receptors in severe and non-severe covid-19 patients Open
View article: Integration of phytotherapy and chemotherapy: Recent advances in anticancer molecular pathways.
Integration of phytotherapy and chemotherapy: Recent advances in anticancer molecular pathways. Open
Cancer is a disease characterized by abnormal and uncontrolled growth of cells, leading to invasion and metastasis to other tissues. Chemotherapy drugs are some of the primary treatments for cancer, which could detrimentally affect the can…
View article: Combination Effect of Ginger and Rosemary Extracts on CT-26 Mouse Colorectal Cancer Cells
Combination Effect of Ginger and Rosemary Extracts on CT-26 Mouse Colorectal Cancer Cells Open
Introduction: This study aimed to evaluate the potential apoptotic effects of Zingiber officinale Roscoe (ginger) and Rosmarinus Officinalis L. (rosemary) combination extracts on the mouse colorectal cancer cell line. Methods: After the pr…
View article: Anti-tumor effects of PEGylated-nanoliposomes containing ginger extract in colorectal cancer-bearing mice.
Anti-tumor effects of PEGylated-nanoliposomes containing ginger extract in colorectal cancer-bearing mice. Open
Results indicated that the liposomal ginger enhanced the antitumor activity; therefore, the prepared liposomal ginger can be used in future clinical trials.
View article: Reduced IL-37 gene expression and CD8 T lymphocytes in patients with metastatic breast cancer
Reduced IL-37 gene expression and CD8 T lymphocytes in patients with metastatic breast cancer Open
The exact immunopathological mechanisms in the progression of breast cancer are not clearly understood, but various factors including CD8 T lymphocytes have lethal properties on tumor cells. On the other hand, interleukin-37 (IL-37), as a …
View article: A Randomized Controlled Trial of Hydroxychloroquine as Prophylaxis for COVID-19 among Health Care Providers
A Randomized Controlled Trial of Hydroxychloroquine as Prophylaxis for COVID-19 among Health Care Providers Open
Background: Although there is a growing consensus that hydroxychloroquine may not be effective in the treatment of COVID-19 patients, there is still little high-quality evidence about the prophylactic effects of this medication. In this st…
View article: Observing the Anti-oxidant and Anti-inflammatory Effect of Nigella Sativa Combined With Silybum Marianum Extracts on the Acute Peritonitis Mouse Model
Observing the Anti-oxidant and Anti-inflammatory Effect of Nigella Sativa Combined With Silybum Marianum Extracts on the Acute Peritonitis Mouse Model Open
Background and Aim: In addition to free radicals such as Nitric Oxide (NO), inflammation is one of the most important pathophysiological causes of peritonitis. Over thousands of years, Nigella Sativa (NS) and Silybum Marianum (SM) are two …
View article: Anti-Inflammatory Activity of S. Marianum and N. Sativa Extracts on Macrophages
Anti-Inflammatory Activity of S. Marianum and N. Sativa Extracts on Macrophages Open
These results suggest that an SME and NEE mixture has anti-inflammatory and immunomodulatory activities and may be useful in the treatment of diseases of immunopathologic origin characterized by macrophage hyperactivation.
View article: Alterations in The Plasma Expression of mir-15b, mir-195 and the Tumor-Suppressor Gene DLEU7 in Patients with B-Cell Chronic Lymphocytic Leukemia
Alterations in The Plasma Expression of mir-15b, mir-195 and the Tumor-Suppressor Gene DLEU7 in Patients with B-Cell Chronic Lymphocytic Leukemia Open
Both miR-15b and miR-195, have the potential to function as novel and non-invasive biomarkers in the diagnosis and prognosis of patients with B-CLL.
View article: Changes in Expression of miR-1297 and PTEN Tumor Suppressor Gene in T-cell Acute Lymphoblastic Leukemia
Changes in Expression of miR-1297 and PTEN Tumor Suppressor Gene in T-cell Acute Lymphoblastic Leukemia Open
Background and purpose: T-cell acute lymphoblastic leukemia (T-ALL) is a type of blood malignancy caused by changes in the precursors of T lymphocyte cells. The PTEN gene is one of the most common tumor suppressor genes that mutates in mos…
View article: Diagnostic Value of Plasma miR-145 and miR-185 as Targeting of the APRIL Oncogene in the B-cell Chronic Lymphocytic Leukemia
Diagnostic Value of Plasma miR-145 and miR-185 as Targeting of the APRIL Oncogene in the B-cell Chronic Lymphocytic Leukemia Open
These data suggest that miR-145-5p and miR-185-5p target the APRIL gene and might have a role in diagnosis of B-CLL. Therefore, these two miRNAs can be served as a novel and potential biomarker for detection of B-CLL.
View article: Reduction of Inflammatory C3 and C4 Complement Proteins in Severe COVID-19 Patients
Reduction of Inflammatory C3 and C4 Complement Proteins in Severe COVID-19 Patients Open
Background: The complement system, consisting of more than 20 soluble proteins, has a key role in innate immunity and inflammation that eliminates pathogens and viral infections. Therefore, we investigated the titer of C3, C4, and total Ig…
View article: <i>In vivo</i> therapeutic effects of colorectal cancer cell-derived exosomes.
<i>In vivo</i> therapeutic effects of colorectal cancer cell-derived exosomes. Open
The present results revealed that subcutaneous administration of tumor-derived exosomes could effectively lead to the inhibition of tumor progression by decreasing the number of Treg cells and up-regulation of the IFN-γ gene. Therefore, tu…
View article: Cytokine profile and disease severity in patients with COVID-19
Cytokine profile and disease severity in patients with COVID-19 Open
View article: In vitro Anti-inflammatory Effects of Satureja Kkhuzestanica Essential Oil Compared to Carvacrol
In vitro Anti-inflammatory Effects of Satureja Kkhuzestanica Essential Oil Compared to Carvacrol Open
Introduction: Satureja khozestanica grows mainly in the southwest part of Iran as a native plant. This edible herb contains various compounds including the S. Khuzestanica essential oil (SKEO) and monoterpene known as Carvacrol. Previous s…
View article: A Review of the 2019 Novel Coronavirus (Covid-19): Immunopathogenesis, Molecular Biology and Clinical Aspects
A Review of the 2019 Novel Coronavirus (Covid-19): Immunopathogenesis, Molecular Biology and Clinical Aspects Open
A Review of the 2019 Novel Coronavirus (Covid-19): Immunopathogenesis, Molecular Biology and Clinical Aspects
View article: Increased expression of CD8 marker on T-cells in COVID-19 patients
Increased expression of CD8 marker on T-cells in COVID-19 patients Open
View article: Diagnostic value of serum miR-145 and miR-185 as targeting of the APRIL oncogene in the B-cell chronic lymphocytic leukemia
Diagnostic value of serum miR-145 and miR-185 as targeting of the APRIL oncogene in the B-cell chronic lymphocytic leukemia Open
Background: Chronic lymphocytic leukemia (CLL) is one of the most common hematologic malignancy in adults worldwide. This cancer has a poor prognosis at different stages. So, the identification of new biomarkers is important for early diag…
View article: <p>Alteration in Expression of miR-32 and FBXW7 Tumor Suppressor in Plasma Samples of Patients with T-cell Acute Lymphoblastic Leukemia</p>
Alteration in Expression of miR-32 and FBXW7 Tumor Suppressor in Plasma Samples of Patients with T-cell Acute Lymphoblastic Leukemia Open
miR-32 is considered as a novel oncomir that targets FBXW7 and might have a role in the etiology or progression of T-ALL. Furthermore, miR-32 can potentially serve as a non-invasive biomarker for detection of T-ALL.
View article: Bioinformatic Prediction of miRNAs Targeting APRIL and BAFF Genes in Chronic Lymphocytic Leukemia
Bioinformatic Prediction of miRNAs Targeting APRIL and BAFF Genes in Chronic Lymphocytic Leukemia Open
View article: An Overview of Antimicrobial Peptides as Anticancer Agents
An Overview of Antimicrobial Peptides as Anticancer Agents Open