Explanipedia

Modeling the impact of intercellular signaling on dose metrics and therapeutic outcomes in spatially fractionated radiation therapy (SFRT) for lung cancer Open

Elnaz Balvasi, Farshid Mahmoudi, Ghazale Geraily, Parissa Farnia, Fatemeh Jafari · 2025

Spatially fractionated radiation therapy (SFRT) delivers heterogeneous dose distributions to enhance tumor control while reducing normal tissue toxicity. Since conventional models like the linear-quadratic (LQ) model overlook intercellular…

Quantitative assessment of treatment planning dosimetric parameters in 3D-CRT with the mixed photon-electron beams versus IMRT for the nasopharyngeal carcinoma Open

Hedayatolah Ahmadpour, Alireza Mohammadkarim, Ali Kazemian, Ghazale Geraily, Payman Hejazi , et al. · 2025

Evaluation of the geometric and dosimetric accuracies of deformable image registration of targets and critical organs in prostate CBCT‐guided adaptive radiotherapy Open

Hussam Hameed Jassim, Hassan Ali Nedaie, Nooshin Banaee, Ghazale Geraily, Ali Kazemian , et al. · 2024

Purpose Kilovoltage cone beam computed tomography (kVCBCT)‐guided adaptive radiation therapy (ART) uses daily deformed CT (dCT), which is generated automatically through deformable registration methods. These registration methods may perfo…

Monte Carlo Simulation for the Radixact™ Tomotherapy Linac Using EGSnrc Open

Danial Seifi Makrani, Hassan Ali Nedaei, Ghazale Geraily, Alireza Khorami-Moghaddam, Nooshin Banaee , et al. · 2024

Purpose: When exact information regarding the treatment head and initial electron beam is available, the Monte Carlo (MC) approach can properly simulate any linear accelerator. However, manufacturers seldom offer information such as the in…

Beam quality and the mystery behind the lower percentage depth dose in grid radiation therapy Open

Amir Hossein Karimi, Indra J. Das, Nahid Chegeni, Iraj Jabbari, Fatemeh Jafari , et al. · 2024

Grid therapy recently has been picking momentum due to favorable outcomes in bulky tumors. This is being termed as Spatially Fractionated Radiation Therapy (SFRT) and lattice therapy. SFRT can be performed with specially designed blocks ma…

Depth-Dependent Poly-Energetic Dose Point Kernel (Dpk) in Water for Flattened and Un-Flattened Photon Beam-Small Fields Study Open

Tahereh Hadisinia, Ghazale Geraily, Etesami Mohsen, Hoseini-Ghahfarokhi Mojtaba · 2024

Assessing the Risk of Secondary Cancer Induction in Radiosensitive Organs During Trigeminal Neuralgia Treatment With Gamma Knife Radiosurgery: Impact of Extracranial Dose Open

Ghazale Geraily, A Améri, Atefeh Mahmoudi, Mohadese Moafee, Javad Teymouri · 2023

Purpose Gamma knife radiosurgery (GKRS) delivers high-dose external radiation to a small intracranial lesion. However, scattering and leaked radiation can deposit a portion of the dose outside the radiation field, which may pose a risk to …

Move up to MRI guided Gamma Knife radiosurgery: A Monte Carlo study on dose distribution changes Open

Ali Ameri, Ghazale Geraily, Mehdi Shojaei, Amir Hossein Karimi · 2023

This study explores the feasibility of integrating Magnetic Resonance Imaging (MRI) with the Gamma Knife Icon (GKI™) for real-time monitoring during radiosurgery. The use of MRI could improve treatment accuracy and safety, but combining it…

Investigating the performance of susceptibility-weighted images in Fricke gel dosimeter reading and optimizing the related imaging parameters Open

Soheil Elmtalab, Seyedeh Fereshteh Ghazi Mir Saeid, Hamidreza Saligheh Rad, Ghazale Geraily · 2023

Fricke gel dosimeters are especially useful in small-field dosimetry and validation of treatment delivery in three-dimensional space with features such as tissue equivalence, non-toxicity, high spatial resolution, non-dependence on energy,…

Investigation of TG-43 Dosimetric Parameters for 192Ir Brachytherapy Source Using GATE Monte Carlo Code Open

Musa Joya, Hassan Ali Nedaie, Ghazale Geraily, Hadi Rezaei, Awaz Bromand , et al. · 2023

Purpose: According to the revised Task Group number 43 recommendations, a brachytherapy source must be validated against a similar or identical source before its clinical application. The purpose of this investigation is to verify the dosi…

The geometric and dosimetric accuracy of kilovoltage cone beam computed tomography images for adaptive treatment: a systematic review Open

Hussam Jassim, Hassan Ali Nedaei, Ghazale Geraily, Nooshin Banaee, Ali Kazemian · 2023

Objectives: To provide an overview and meta-analysis of different techniques adopted to accomplish kVCBCT for dose calculation and automated segmentation. Methods: A systematic review and meta-analysis were performed on eligible studies de…

How much should you worry about contaminant neutrons in spatially fractionated grid radiation therapy? Open

Farshid Mahmoudi, Najmeh Mohammadi, Meysam Haghighi, Zahra Alirezaei, Iraj Jabbari , et al. · 2023

Neutron contamination in radiation therapy is of concern in treatment with high-energy photons (> 10 MV). With the development of new radiotherapy modalities such as spatially fractionated grid radiation therapy (SFGRT) or briefly grid rad…

Apigenin-Melatonin: a novel prostate cancer Radiation Sensitizer Open

Morteza Taghavi Bahreghani, Shaban Alizadeh, Ghazale Geraily, Mehdi Shojaei, Alireza Shirazi , et al. · 2023

Background : Radiotherapy is a common modality in prostate cancer (PrCa), with a dose of 80Gy. A higher dose of ionizing radiation is often needed to achieve an appropriate response; however, clinical evidence indicates that increasing the…

Move Up to MRI Guided Gamma Knife Radiosurgery: A Monte Carlo Study on Change in Dose Distribution Open

Ali Ameri, Ghazale Geraily, Mehdi Shojaei, Amir Hossein Karimi · 2023

Dosimetric comparison between microSelectron iridium-192 and flexi cobalt-60 sources in high-dose-rate brachytherapy using Geant4 Monte Carlo code Open

Tsige Yhidego Gebremariam, Ghazale Geraily, Hussam Hameed Jassim, Somayeh Gholami · 2023

The primary photons from the lower-energy HDR microSelectron ¹⁹²Ir source have a limited range and are partially attenuated when considering the results of radial and anisotropic dose distribution functions. This implies that a …

An Investigation of Dosimetric Consequences of the Anatomic Changes at First Fraction in VMAT of Prostate Cancer Cases using Deformable Planning CT and KVCBCT Image Registration Open

Hussam Hameed Jassim, Hassan Ali Nedaei, Nooshin Banaee, Ghazale Geraily, Ali Kazemian · 2023

The use of VMAT based on kilovoltage kVCBCT and Deformtion Image Registration (DIR) can lead to re-decreasing the dose to the bladder while increasing that to the rectum, with the same PTV dose coverage.

Efficacy of Nanoparticles in dose enhancement with high dose rate of Iridium-192 and Cobalt-60 radionuclide sources in the Treatment of Cancer: A systematic review Open

Tsige Yhidego Gebremariam, Ghazale Geraily, Amanuel Godana Arero, Somayeh Gholami · 2023

S A key challenge in radiation therapy is to maximize the radiation dose to cancer cells while minimizing damage to healthy tissues. In recent years, the introduction of remote after-loading technology such as high-dose-rate (HDR) brachyth…

Gamma Knife Icon™ Single Sector Characterization Based on Monte Carlo Simulation Open

Ali Ameri, Ghazale Geraily · 2022

Purpose: Gamma Knife Radiosurgery refers to surgery using radiation to destroy intracranial tissues or lesions elusive or unsuitable for open surgery. This study aimed to simulate the Gamma Knife Icon™ (GKI™) single sector to assess variou…

An Investigation into the Surface Dose Using Eclipse Treatment Planning System and Film Dosimetry for Treatment of Breast Cancer Open

Nooshin Sheykholeslami, Wrya Parwaie, Mostafa Farzin, Vahid Vaezzadeh, Ghazale Geraily · 2022

Purpose: Accurate knowledge about surface dose distribution is a critical issue in skin irradiation. This study was conducted to investigate the surface dose using the Eclipse Treatment Planning System (TPS) calculation and GAF chromic fil…

Semi-experimental assessment of neutron equivalent dose and secondary cancer risk for off-field organs in glioma patients undergoing 18-MV radiotherapy Open

Soheil Elmtalab, Iraj Abedi, Zahra Alirezaei, M.H. Choopan Dastjerdi, Ghazale Geraily , et al. · 2022

Neutron contamination as a source of out-of-field dose in radiotherapy is still of concern. High-energy treatment photons have the potential to overcome the binding energy of neutrons inside the nuclei. Fast neutrons emitting from the acce…

Dosimetry of small photon fields in the presence of bone heterogeneity using MAGIC polymer gel, Gafchromic film, and Monte Carlo simulation Open

Werya Parwaie, Ghazale Geraily, Ghazal Mehri-Kakavand, Somayeh Babaloui, Samira Rezvani , et al. · 2022

The results presented that the MAGIC polymer gel dosimeter is a proper instrument for dosimetry beyond high density heterogeneity.

BEBIG 60Co HDR brachytherapy source dosimetric parameters validation using GATE Geant4-based simulation code Open

Musa Joya, Hassan Ali Nedaie, Ghazale Geraily, Mahdi Ghorbani, Peyman Sheikhzadeh , et al. · 2022

Findings from this investigation revealed that the validation of the HDR ⁶⁰Co source is feasible by the GATE Geant4-based Monte Carlo code. As a result, the GATE Monte Carlo code can be used for the verification of the brachythe…

Comparison of organs at risk doses between deep inspiration breath-hold and free-breathing techniques during radiotherapy of left-sided breast cancer: A Meta-Analysis Open

Eyachew Misganew Tegaw, Getu Ferenji Tadesse, Ghazale Geraily, Somayeh Gholami, W Gebreamlak · 2022

After radiotherapy (RT) of left-sided breast cancer patients, organs at risk (OARs) such as heart, left anterior descending (LAD) coronary artery, and left lung could be affected by radiation dose in the long term. The objective of this st…

Novel Application of Ferrous-Methylthymol Blue- Polyvinyl Alcohol- Glutaraldehyede Gel Dosimeter as a Bolus Open

Nooshin Sheykholeslami, Werya Parwaie, Amir Hossein Karimi, Vahid Vaezzadeh, Mostafa Farzin , et al. · 2022

The effect of fractionated gamma knife radiosurgery on visual acuity in patients with optic nerve tumor Open

Farid Kazemi Gazik, Maziar Azar, Foad Kazemi, Tahereh Hadisinia, Javad Teimouri , et al. · 2021

Fractionated gamma knife radiosurgery offers a safe and effective alternative for benign lesions adjacent to the optic nerve.

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Tahereh Hadisinia, Ghazale Geraily, Seyed Mohsen Etesami, Mojtaba Hoseini‐Ghahfarokhi, Atefeh Mahmoudi , et al. · 2021

Although the density scaling method has acceptable accuracy, the error values are significant at the location of lung or bone voxels. By using the mentioned correction factors, the calculation inaccuracy of heterogeneous EDKs can be reduce…

Comparison of dosimetric characteristics of physical wedge and enhanced dynamic wedge in inhomogeneous medium using Monte Carlo simulations Open

Seied Rabi Mahdavi, Atefeh Mahmoudi, Ghazale Geraily, Ahmad Mostaar, Golbarg Esmaili · 2021

Results demonstrated that it is possible to apply PW data instead of EDW due to the dosimetry and commissioning hardships caused by EDW in inhomogeneous media.

Evaluation of Dose Distribution in Optimized Stanford Total Skin Electron Therapy (TSET) Technique in Rando Anthropomorphic Phantom using EBT3 Gafchromatic Films Open

Shaghayegh Fahimi Monzari, Ghazale Geraily, Mehdi Aghili, Heydar Toolee · 2021

Total Skin Electron Therapy (TSET) technique in sleeping position is very suitable for elderly and disabled patients, and meets the required dose uniformity. Furthermore, the use of a flattening filter is recommended for the more dose dist…

Evaluation of ferrous benzoic methylthymol-blue gel as a dosimeter via magnetic resonance imaging Open

Wrya Parwaie, Ghazale Geraily, Alireza Shirazi, Ghazal Mehri-Kakavand, Mostafa Farzin · 2020

EGSnrc/BEAMnrc-Based Monte Carlo Simulation of the Gamma Knife 4C versus MCNP Code in Homogeneous Media Open

Atefeh Mahmoudi, Ghazale Geraily · 2020

Purpose: Gamma Knife is applied as a superseded tool for inaccessible lesions surgery delivering a single high dose to a well-defined target through 201 small beams. Monte Carlo simulations can be an appropriate supplementary tool to deter…

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