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View article: Nuclear respiratory factor 1 promotes cell survival in multiple myeloma under proteasome inhibition therapy
Nuclear respiratory factor 1 promotes cell survival in multiple myeloma under proteasome inhibition therapy Open
Multiple myeloma (MM) continues to be an incurable malignancy, even with recent therapeutic advancements. While epigenetic dysregulation at cis-regulatory elements is known to drive disease progression, the complete molecular mechanisms un…
View article: p63 and ZNF148 cooperate to regulate head and neck squamous cell carcinoma
p63 and ZNF148 cooperate to regulate head and neck squamous cell carcinoma Open
Head and neck squamous cell carcinoma (HNSCC) is a common and aggressive malignancy. While significant advances have been made in the management of low-grade cancer, treatment of advanced HNSCC remains challenging. Here, we used a proteomi…
View article: Targeting of a novel interplay between MET Tyrosine Kinase and NRF2 enhances sensitivity to Paclitaxel in Triple Negative Breast Cancer
Targeting of a novel interplay between MET Tyrosine Kinase and NRF2 enhances sensitivity to Paclitaxel in Triple Negative Breast Cancer Open
Background Triple-negative breast cancer (TNBC) is a very aggressive and heterogeneous cancer. The lack of effective targeted therapies and frequency of relapse point to the urgent need for identifying molecular vulnerabilities to overcome…
View article: HBV-driven host chromatin accessibility changes affect liver metabolic pathways, iron homeostasis and promote a preneoplastic phenotype
HBV-driven host chromatin accessibility changes affect liver metabolic pathways, iron homeostasis and promote a preneoplastic phenotype Open
View article: WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells
WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells Open
N 6 -methyladenosine (m 6 A) is one of the most prevalent and conserved RNA modifications. It controls several biological processes, including the biogenesis and function of circular RNAs (circRNAs), which are a class of covalently closed-…
View article: Che-1/miR-590-3p/TAZ axis sustains multiple myeloma disease
Che-1/miR-590-3p/TAZ axis sustains multiple myeloma disease Open
Multiple myeloma (MM) is a blood disease characterized by the malignant accumulation of monoclonal plasma cells in the bone marrow. Among the pathological consequences of the MM, defects in osteogenesis characterized by osteolytic lesions,…
View article: Deciphering Mutational Signature Dynamics in Hormone-Sensitive Breast Cancer During Treatment Adaptation.
Deciphering Mutational Signature Dynamics in Hormone-Sensitive Breast Cancer During Treatment Adaptation. Open
The DNA accumulates somatic changes before and after tumor initiation. These changes have been classified into mutational signatures (1) but only recently have studies begun to experimentally validate and functionally dissect these signatu…
View article: hMENA isoforms regulate cancer intrinsic type I IFN signaling and extrinsic mechanisms of resistance to immune checkpoint blockade in NSCLC
hMENA isoforms regulate cancer intrinsic type I IFN signaling and extrinsic mechanisms of resistance to immune checkpoint blockade in NSCLC Open
Background Understanding how cancer signaling pathways promote an immunosuppressive program which sustains acquired or primary resistance to immune checkpoint blockade (ICB) is a crucial step in improving immunotherapy efficacy. Among the …
View article: Che-1/miR-590-3p/TAZ axis sustains multiple myeloma disease.
Che-1/miR-590-3p/TAZ axis sustains multiple myeloma disease. Open
Multiple myeloma (MM) is a blood disease characterized by the malignant accumulation of monoclonal plasma cells in the bone marrow. Among the pathological consequences of MM, defects in osteogenesis characterized by osteolytic lesions, ost…
View article: The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation
The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation Open
View article: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B Open
View article: <scp>AATF</scp> /Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma
<span>AATF</span> /Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma Open
View article: AATF/Che-1, a new component of paraspeckles, controls R-loops formation and Interferon activation in Multiple Myeloma
AATF/Che-1, a new component of paraspeckles, controls R-loops formation and Interferon activation in Multiple Myeloma Open
Multiple myeloma (MM) is a hematological neoplasm of plasma cells characterized by abnormal production of immunoglobulins. Che-1/AATF (Che-1) is an RNA binding protein involved in transcription regulation and is highly expressed in this ma…
View article: Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma
Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma Open
Multiple myeloma (MM) is a hematologic malignancy produced by a clonal expansion of plasma cells and characterized by abnormal production and secretion of monoclonal antibodies. This pathology exhibits an enormous heterogeneity resulting n…
View article: KEAP1-driven co-mutations in lung adenocarcinoma unresponsive to immunotherapy despite high tumor mutational burden
KEAP1-driven co-mutations in lung adenocarcinoma unresponsive to immunotherapy despite high tumor mutational burden Open
View article: Small extracellular vesicles deliver miR‐21 and miR‐217 as pro‐senescence effectors to endothelial cells
Small extracellular vesicles deliver miR‐21 and miR‐217 as pro‐senescence effectors to endothelial cells Open
The role of epigenetics in endothelial cell senescence is a cutting‐edge topic in ageing research. However, little is known of the relative contribution to pro‐senescence signal propagation provided by microRNAs shuttled by extracellular v…
View article: Eleven grand challenges in single-cell data science
Eleven grand challenges in single-cell data science Open
View article: GeDi: applying suffix arrays to increase the repertoire of detectable SNVs in tumour genomes
GeDi: applying suffix arrays to increase the repertoire of detectable SNVs in tumour genomes Open
Background Current popular variant calling pipelines rely on the mapping coordinates of each input read to a reference genome in order to detect variants. Since reads deriving from variant loci that diverge in sequence substantially from t…
View article: Additional file 2 of GeDi: applying suffix arrays to increase the repertoire of detectable SNVs in tumour genomes
Additional file 2 of GeDi: applying suffix arrays to increase the repertoire of detectable SNVs in tumour genomes Open
Additional file 2 raw_data.zip is available online and contains raw data for generating the figures and tables presented in the main text and SupplementaryData.pdf.
View article: B4GALT1 Is a New Candidate to Maintain the Stemness of Lung Cancer Stem Cells
B4GALT1 Is a New Candidate to Maintain the Stemness of Lung Cancer Stem Cells Open
Background: According to the cancer stem cells (CSCs) hypothesis, a population of cancer cells with stem cell properties is responsible for tumor propagation, drug resistance, and disease recurrence. Study of the mechanisms responsible for…
View article: Peer Review #1 of "The co-expression networks of differentially expressed RBPs with TFs and LncRNAs related to clinical TNM stages of cancers (v0.2)"
Peer Review #1 of "The co-expression networks of differentially expressed RBPs with TFs and LncRNAs related to clinical TNM stages of cancers (v0.2)" Open
Background: RNA-binding proteins (RBPs) play important roles in cellular homeostasis by regulating the expression of thousands of transcripts, which have been reported to be involved in human tumorigenesis.Despite previous reports of the d…
View article: Peer Review #1 of "The co-expression networks of differentially expressed RBPs with TFs and LncRNAs related to clinical TNM stages of cancers (v0.1)"
Peer Review #1 of "The co-expression networks of differentially expressed RBPs with TFs and LncRNAs related to clinical TNM stages of cancers (v0.1)" Open
Background: RNA-binding proteins (RBPs) play important roles in cellular homeostasis by regulating the expression of thousands of transcripts, which have been reported to be involved in human tumorigenesis.Despite previous reports of the d…
View article: Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy Open
View article: 12 Grand Challenges in Single-Cell Data Science
12 Grand Challenges in Single-Cell Data Science Open
The recent upswing of microfluidics and combinatorial indexing strategies, further enhanced by very low sequencing costs, have turned single cell sequencing into an empowering technology; analyzing thousands—or even millions—of cells per e…
View article: 12 Grand challenges in single-cell data science
12 Grand challenges in single-cell data science Open
The recent upswing of microfluidics and combinatorial indexing strategies, further enhanced by very low sequencing costs, have turned single cell sequencing into an empowering technology; analyzing thousands—or even millions—of cells per e…
View article: 12 Grand Challenges in Single-Cell Data Science
12 Grand Challenges in Single-Cell Data Science Open
The recent upswing of microfluidics and combinatorial indexing strategies, further enhanced by very low sequencing costs, have turned single cell sequencing into an empowering technology; analyzing thousands—or even millions—of cells per e…
View article: 12 Grand challenges in single-cell data science
12 Grand challenges in single-cell data science Open
The recent upswing of microfluidics and combinatorial indexing strategies, further enhanced by very low sequencing costs, have turned single cell sequencing into an empowering technology; analyzing thousands—or even millions—of cells per e…
View article: Epigenomic and genomic dissection of oestrogen receptor-positive breast cancer
Epigenomic and genomic dissection of oestrogen receptor-positive breast cancer Open
Genetic and Epigenetic mechanisms underlie the natural complexity of phenotypical and morphological aspects of cancer. Extensive phenotypical intra and inter-patient heterogeneity of cancer specimens is a relevant limiting factor in cancer…
View article: Single-cell Transcriptomics reveals multi-step adaptations to endocrine therapy
Single-cell Transcriptomics reveals multi-step adaptations to endocrine therapy Open
Resistant tumours are thought to arise from the action of Darwinian selection on genetically heterogenous cancer cell populations. However, simple clonal selection is inadequate to describe the late relapses often characterising luminal br…
View article: Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer
Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer Open