Giacomo Grillo
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View article: Genetic and Epigenetic Reprogramming of Transposable Elements Drives ecDNA-Mediated Metastatic Prostate Cancer
Genetic and Epigenetic Reprogramming of Transposable Elements Drives ecDNA-Mediated Metastatic Prostate Cancer Open
Extrachromosomal DNAs (ecDNAs), which replicate and segregate in a non-Mendelian manner, serve as vectors for accelerated tumor evolution. By integrating chromatin accessibility, whole-genome sequencing, and Hi-C-based genome topology data…
View article: ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats
ZBTB24 is a conserved multifaceted transcription factor at genes and centromeres that governs the DNA methylation state and expression of satellite repeats Open
Since its discovery as a causative gene of the Immunodeficiency with Centromeric instability and Facial anomalies syndrome, ZBTB24 has emerged as a key player in DNA methylation, immunity and development. By extensively analyzing ZBTB24 ge…
View article: Supplementary Table S4 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S4 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
pluripotent stem cell- and tissue state-specific transposable element families
View article: Data from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Data from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Transposable elements hold regulatory functions that impact cell fate determination by controlling gene expression. However, little is known about the transcriptional machinery engaged at transposable elements in pluripotent and mature ver…
View article: Supplementary Table S3 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S3 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Pluripotent stem cells enriched transposable element families versus individual tissue states
View article: Supplementary Table S23 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S23 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Top 5% transcription factor cistromes enriched at reprogrammed transposable element families (Porto constant patients)
View article: Supplementary Table S11 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S11 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
AR GIGGLE enrichment scores at AR-bound benign prostate transposable elements
View article: Supplementary Table S7 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S7 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Top 5% transcription factor cistromes enriched at benign prostate transposable elements
View article: Supplementary Table S11 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S11 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
AR GIGGLE enrichment scores at AR-bound benign prostate transposable elements
View article: Supplementary Table S23 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S23 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Top 5% transcription factor cistromes enriched at reprogrammed transposable element families (Porto constant patients)
View article: Supplementary Table S2 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S2 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Tissue-state enriched transposable element families vs pluripotent stem cells
View article: Supplementary Figure S3 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Figure S3 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
This figure showcases the entire molecular and clinical characterization of CPC-GENE and Porto patients' groups identified using transposable element families differentially enriched between pluripotent stem cells and benign prostate tissu…
View article: Supplementary Table S20 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S20 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Top 5% transcription factor cistromes enriched at reprogrammed transposable element families (CPC-GENE reprogrammed patients)
View article: Supplementary Table S13 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S13 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Differentially enriched transposable element families between reprogrammed and constant CPC-GENE patients
View article: Supplementary Figure S2 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Figure S2 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
This figure complements Figure 2 and showcases the enrichment of tranposable element families in TCGA PRAD ATAC data
View article: Supplementary Table S21 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S21 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Top 5% transcription factor cistromes enriched at reprogrammed transposable element families (Porto reprogrammed patients)
View article: Supplementary Table S10 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S10 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Top 5% transcription factor cistromes enriched at lung transposable elements
View article: Supplementary Figure S5 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Figure S5 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
This figure showcases the enrichment of transposable element families in H3K27ac or H3K9kme3 ChIP-seq data generated in benign-like and prostate cancer cell lines. It also includes dCas9-KRAB expression patterns in all CRISPRi clonal cell …
View article: Supplementary Table S8 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S8 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Top 5% transcription factor cistromes enriched at intestine transposable elements
View article: Supplementary Table S13 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S13 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Differentially enriched transposable element families between reprogrammed and constant CPC-GENE patients
View article: Supplementary Table S3 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S3 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Pluripotent stem cells enriched transposable element families versus individual tissue states
View article: Supplementary Table S24 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S24 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Pathwyas significantly different in all three CRISPRi 22Rv1 clones (Tigger3a vs Control)
View article: Supplementary Table S16 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S16 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Onco-exaptated transposable elements in reprogrammed and constant PCa patients
View article: Supplementary Figure S2 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Figure S2 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
This figure complements Figure 2 and showcases the enrichment of tranposable element families in TCGA PRAD ATAC data
View article: Supplementary Table S14 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S14 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Differentially enriched transposable element families between reprogrammed and constant Porto patients
View article: Supplementary Table S22 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S22 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Top 5% transcription factor cistromes enriched at reprogrammed transposable element families (CPC-GENE constant patients)
View article: Supplementary Table S16 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S16 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
Onco-exaptated transposable elements in reprogrammed and constant PCa patients
View article: Supplementary Figure S6 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Figure S6 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
This figure showcases dCas9-KRAB and H3K27ac profiling in CRISPRi 22Rv1 clones #1 and #3 nucleofected with control or Tigger3a gRNA combos (clone #2 is showcased in Figure 5)
View article: Supplementary Table S25 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Table S25 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
List of gRNA sequences used in this article
View article: Supplementary Figure S1 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer
Supplementary Figure S1 from Transposable Elements Are Co-opted as Oncogenic Regulatory Elements by Lineage-Specific Transcription Factors in Prostate Cancer Open
This figure contains the roadmap for all the different datasets used in this study. It also showcases transcription factor and motif enrichment over transposable element families enriched in different normal tissues states