Giacomo Stroffolini
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View article: The virulence toolkit of Staphylococcus aureus: a comprehensive review of toxin diversity, molecular mechanisms, and clinical implications
The virulence toolkit of Staphylococcus aureus: a comprehensive review of toxin diversity, molecular mechanisms, and clinical implications Open
View article: Ocular surface microbiome: Influences of physiological, environmental, and lifestyle factors
Ocular surface microbiome: Influences of physiological, environmental, and lifestyle factors Open
This study underscores the importance of considering PEL factors when studying the ocular microbiome. Our findings highlight the complex interplay between environmental, lifestyle, and demographic factors in shaping the OS microbiome. Futu…
View article: The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis
The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis Open
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View article: Evaluation of the Use of Preventive Antibiotic Therapy in Patients Undergoing One-Step Prosthetic Revision Surgery with Low Preoperative Infectious Risk
Evaluation of the Use of Preventive Antibiotic Therapy in Patients Undergoing One-Step Prosthetic Revision Surgery with Low Preoperative Infectious Risk Open
Introduction: The prosthetic knee infection (PKI) rate in most centers ranges from 0.5 to 2% for knee replacements, depending on risk factors. Current PKI definitions may miss the identification of both early and late complications. There …
View article: Multidrug-Resistant <i>Mycobacterium tuberculosis</i> in a Community Hospital, Luanda, Angola
Multidrug-Resistant <i>Mycobacterium tuberculosis</i> in a Community Hospital, Luanda, Angola Open
In a longitudinal study in a first-level hospital in Luanda, Angola, we found rifampin-resistant and multidrug-resistant tuberculosis (TB) in 38 (8%, 95% CI 5.7-10.8) of 474 patients with no previous history of TB. Of note, 2 patients (0.4…
View article: Insights into the ecological and climate crisis: Emerging infections threatening human health
Insights into the ecological and climate crisis: Emerging infections threatening human health Open
The Anthropocene era is marked by unprecedented human-induced alterations to the environment, resulting in a climate emergency and widespread ecological deterioration. A staggering number of up to one million species of plants and animals …
View article: Navigating healthcare pathways: Cascade of prevention and care for chronic viral hepatitis in asylum seekers and refugees. A multicenter analysis in Northern Italy
Navigating healthcare pathways: Cascade of prevention and care for chronic viral hepatitis in asylum seekers and refugees. A multicenter analysis in Northern Italy Open
Viral hepatitis is a leading cause of mortality and a global public health challenge that, until recently, has been largely neglected as a health priority. This study describes the prevalence of viral hepatitis B and C in asylum seekers an…
View article: Fluoroquinolones and Biofilm: A Narrative Review
Fluoroquinolones and Biofilm: A Narrative Review Open
Background: Biofilm-associated infections frequently span multiple body sites and represent a significant clinical challenge, often requiring a multidisciplinary approach involving surgery and antimicrobial therapy. These infections are co…
View article: Prescription habits and drugs accessibility for the treatment of non-tuberculous mycobacteria infections in Italy: a multicentric survey from the IRENE study group
Prescription habits and drugs accessibility for the treatment of non-tuberculous mycobacteria infections in Italy: a multicentric survey from the IRENE study group Open
View article: Central Nervous System Disorders with Auto-Antibodies in People Living with HIV
Central Nervous System Disorders with Auto-Antibodies in People Living with HIV Open
People living with HIV (PLWH) may present atypical neurological complications. Recently, autoimmune manifestations of the central nervous system (CNS) have been described. We retrospectively described the features of PLWH presenting with a…
View article: Prevalence and Modes of Transmission of Hepatitis C Virus Infection: A Historical Worldwide Review
Prevalence and Modes of Transmission of Hepatitis C Virus Infection: A Historical Worldwide Review Open
Hepatitis C virus infection affects over 58 million individuals and is responsible for 290,000 annual deaths. The infection spread in the past via blood transfusion and iatrogenic transmission due to the use of non-sterilized glass syringe…
View article: Perspectives on climate action and the changing burden of infectious diseases among young Italian doctors and students: a national survey
Perspectives on climate action and the changing burden of infectious diseases among young Italian doctors and students: a national survey Open
Background The eco-climatic crisis has been defined by the World Health Organization as the “single biggest health threat facing humanity,” influencing both the emergence of zoonoses and the spread of vector-borne and water-borne diseases.…
View article: Ocular Surface Microbiome: Influences of Physiological, Environmental, and Lifestyle Factors
Ocular Surface Microbiome: Influences of Physiological, Environmental, and Lifestyle Factors Open
Purpose Purpose: The ocular surface (OS) microbiome is influenced by various factors and impacts ocular health. Understanding its composition and dynamics is crucial for developing targeted interventions for ocular diseases. This study aim…
View article: Patient characteristics and antimicrobial susceptibility profiles of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> infections in international travellers: a GeoSentinel analysis
Patient characteristics and antimicrobial susceptibility profiles of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> infections in international travellers: a GeoSentinel analysis Open
Background Antimicrobial resistance (AMR) is a global health crisis, with Enterobacterales, including Escherichia coli and Klebsiella pneumoniae, playing significant roles. While international travel to low- and middle-income countries is …
View article: Vaccination in Patients with Liver Cirrhosis: A Neglected Topic
Vaccination in Patients with Liver Cirrhosis: A Neglected Topic Open
Patients with liver cirrhosis, due to their weakened innate and adaptive immunity, are more prone to frequent and severe vaccine-preventable infections. Moreover, impaired adaptive immunity results in a limited antibody response to vaccine…
View article: Antimicrobial Resistance in Migratory Paths, Refugees, Asylum Seekers and Internally Displaced Persons: A Narrative Review
Antimicrobial Resistance in Migratory Paths, Refugees, Asylum Seekers and Internally Displaced Persons: A Narrative Review Open
Purpose of Review Antimicrobial resistance (AMR) is a significant global health challenge, especially for populations with limited access to healthcare services and poor living conditions. This narrative review focuses on the determinants …
View article: Low azithromycin maximal concentrations in patients concomitantly taking rifampicin: time to move away from rifampicin in the treatment of non-tuberculous mycobacteria?
Low azithromycin maximal concentrations in patients concomitantly taking rifampicin: time to move away from rifampicin in the treatment of non-tuberculous mycobacteria? Open
View article: Pharmacogenetics of tenofovir drug transporters in the context of HBV: Is there an impact?
Pharmacogenetics of tenofovir drug transporters in the context of HBV: Is there an impact? Open
In conclusion, this is the first study showing a potential impact of genetic variants on TDF plasma and urine concentrations in the HBV context, but further studies in different and larger cohorts of patients are required.
View article: Presumptive pulmonary toxocariasis in a patient affected by acute myeloid leukemia and Hodgkin lymphoma: case report and review of the literature in immunocompromised hosts
Presumptive pulmonary toxocariasis in a patient affected by acute myeloid leukemia and Hodgkin lymphoma: case report and review of the literature in immunocompromised hosts Open
Toxocariasis is a zoonosis transmitted by the nematode Toxocara spp. Immunocompromised hosts are more susceptible than general population to bacterial, viral, fungal and parasitic infections. In this population toxocariasis may pres…
View article: A rare SARS-CoV-2 complication: Candida spondylodiscitis following SARS-CoV-2 infection—two case reports
A rare SARS-CoV-2 complication: Candida spondylodiscitis following SARS-CoV-2 infection—two case reports Open
Background: In the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, opportunistic fungal co-/super-infections have surged globally. This report focuses on Candida spondylodiscitis (CS), an uncommon comp…
View article: Behavioural health issues in post coronavirus disease (COVID) syndrome and suicide risk: a narrative review
Behavioural health issues in post coronavirus disease (COVID) syndrome and suicide risk: a narrative review Open
Background and Objective: Post coronavirus disease (COVID) syndrome includes a wide range of signs and symptoms among which symptoms ascribable to behavioural health issues are as high as 30% for different sub-domains. Recognizing the etio…
View article: HBsAg kinetics after 7 years of therapy with tenofovir disoproxil fumarate in a cohort of naïve patients affected by chronic hepatitis B with different genotypes
HBsAg kinetics after 7 years of therapy with tenofovir disoproxil fumarate in a cohort of naïve patients affected by chronic hepatitis B with different genotypes Open
The role of different genotypes in nucleos(t)ide analogs (NAs) treatment is still debated. Previous studies conducted on special populations evidenced that the E genotype had the lower virological and serological response. This descriptive…
View article: The Diagnosis of Mucormycosis by PCR: A Systematic Review and Meta-Analysis
The Diagnosis of Mucormycosis by PCR: A Systematic Review and Meta-Analysis Open
View article: Switching from tenofovir disoproxil fumarate to tenofovir alafenamide fumarate in a cohort of patients with HBV infection: A retrospective study
Switching from tenofovir disoproxil fumarate to tenofovir alafenamide fumarate in a cohort of patients with HBV infection: A retrospective study Open
Background: Tenofovir disoproxil fumarate (TDF) as first-line therapy for chronic HBV infection is related to nephrotoxicity. Tenofovir alafenamide fumarate (TAF) has been approved with a similar virological and serological response, but l…
View article: Changes in Cerebrospinal Fluid, Liver and Intima-media-thickness Biomarkers in Patients with HIV-associated Neurocognitive Disorders Randomized to a Less Neurotoxic Treatment Regimen
Changes in Cerebrospinal Fluid, Liver and Intima-media-thickness Biomarkers in Patients with HIV-associated Neurocognitive Disorders Randomized to a Less Neurotoxic Treatment Regimen Open
The prevalence of neurocognitive impairment in people living with HIV is estimated between 30 and 50%. The pathogenesis of HIV-associated neurocognitive disorders is complex and multifactorial. Aim of the study was to measure the change in…
View article: Vaccination Campaign against Hepatitis B Virus in Italy: A History of Successful Achievements
Vaccination Campaign against Hepatitis B Virus in Italy: A History of Successful Achievements Open
In Italy, the vaccination campaign against hepatitis B virus has been characterized by two phases. In the first phase (1984–1991), vaccination with plasma-derived vaccines was first recommended for the high-risk group. In the second phase …
View article: Five Decades of HBV Infection in Italy: A Continuous Challenge
Five Decades of HBV Infection in Italy: A Continuous Challenge Open
In Italy, Hepatitis B virus (HBV) infection has been characterized by several changes over the last five decades. In 2019, the incidence of acute HBV among subjects targeted by the vaccination campaign was 0 cases in the age group 0–14 yea…
View article: Real-Life Experience of Continuously Infused Ceftolozane/Tazobactam in Patients with Bronchiectasis and Multidrug-Resistant Pseudomonas aeruginosa Infection in the Outpatient Setting
Real-Life Experience of Continuously Infused Ceftolozane/Tazobactam in Patients with Bronchiectasis and Multidrug-Resistant Pseudomonas aeruginosa Infection in the Outpatient Setting Open
(1) Background: Ceftolozane/tazobactam (C/T) is a novel β-lactam/β-lactamase inhibitor with excellent activity against the multidrug-resistant (MDR) P. aeruginosa. Continuous infusion (CI) dosing allows the optimization of pharmacokinetic …
View article: Impact of preventive chemotherapy on Strongyloides stercoralis: A systematic review and meta-analysis
Impact of preventive chemotherapy on Strongyloides stercoralis: A systematic review and meta-analysis Open
Background Strongyloides stercoralis is a neglected soil-transmitted helminth (STH) that leads to significant morbidity in endemic populations. Infection with this helminth has recently been recognised by the World Health Organization (WHO…
View article: Case Report: Role of Point-of-Care Ultrasound in the Diagnosis of Bacillary Angiomatosis
Case Report: Role of Point-of-Care Ultrasound in the Diagnosis of Bacillary Angiomatosis Open
Clinical skin manifestations are commonly seen in resource-limited settings, but they are frequently misdiagnosed due to the lack of microbiological tests with ensuing stigma and long-term disability. The adoption of portable ultrasound de…