Explanipedia

Spontaneous activity of astrocytes is a stochastic functional signal for memory consolidation Open

Gabriele Losi, Beatrice Vignoli, R. Granata, Annamaria Lia, Micaela Zonta , et al. · 2025

In the absence of explicit neuronal inputs, the glial cell astrocytes exhibit recurring intracellular Ca 2+ fluctuations, primarily localized at thin processes, known as Ca 2+ microdomains (MDs). Although spontaneous Ca 2+ MDs are present …

A Journey between Neurons and Astrocytes: A Tribute to Giorgio Carmignoto Open

Micaela Zonta, Stefano Vicini, Nicoletta Berardi, Lamberto Maffei, Gian Michele Ratto , et al. · 2025

Benchmarking of IMU-based Gait Event Detection Algorithms across Diverse Terrain Conditions Open

Carlota Trigo, Pietro Della Vecchia, Francesco Crenna, Adriana Torres-Pardo, Jorge A. Gómez-García , et al. · 2025

Benchmarking of IMU-based Gait Event Detection Algorithms across Diverse Terrain Conditions Open

Pietro Della Vecchia, Carlota Trigo, Francesco Crenna, Adriana Torres-Pardo, José Gómez-Tames , et al. · 2025

Benchmarking of IMU-Based Gait Event Detection Algorithms Across Diverse Terrain Conditions Open

Carlota Trigo, Pietro Della Vecchia, Francesco Crenna, Adriana Torres-Pardo, Jorge A. Gómez-García , et al. · 2025

This study compares IMU-based gait event detection algorithms on irregular terrains, revealing that performance degrades as terrain complexity increases. Additionally, this study showcases the ability of the standardized EUROBENCH benchmar…

Benchmarking of Imu-Based Gait Event Detection Algorithms Across Diverse Terrain Conditions Open

Carlota Trigo, Pietro Della Vecchia, Francesco Crenna, Adriana Torres-Pardo, José Gómez-Tames , et al. · 2025

Heterogeneity of intracellular calcium signaling of glioblastoma cells depends on intratumoral location and migration state Open

Vinoshene Pillai, Enrico Pracucci, Francesco Trovato, Riccardo Parra, Silvia Landi , et al. · 2025

Background Glioblastoma (GB), is an incurable brain tumor characterized by extreme malignancy and invasiveness, and the cellular mechanisms underlying such a severe phenotype are not completely understood. Although calcium (Ca2+) plays an …

Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model Open

Maria Marchese, Sara Bernardi, Asahi Ogi, Rosario Licitra, Giada Silvi , et al. · 2024

Daily rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability Open

Enrico Pracucci, R. Graham, Laura Alberio, Gabriele Nardi, Olga Cozzolino , et al. · 2023

Cortical activity patterns are strongly modulated by fast synaptic inhibition mediated through ionotropic, chloride-conducting receptors. Consequently, chloride homeostasis is ideally placed to regulate activity. We therefore investigated …

Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2 Open

Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale , et al. · 2023

Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling Open

Jessica Pagano, Silvia Landi, Alessia Stefanoni, Gabriele Nardi, Marica Albanesi , et al. · 2023

Control of circadian rhythm on cortical excitability and synaptic plasticity Open

Claudia Lodovichi, Gian Michele Ratto · 2023

Living organisms navigate through a cyclic world: activity, feeding, social interactions are all organized along the periodic succession of night and day. At the cellular level, periodic activity is controlled by the molecular machinery dr…

Microglial extracellular vesicles induce Alzheimer’s disease-related cortico-hippocampal network dysfunction Open

Chiara Falcicchia, Francesca Tozzi, Martina Gabrielli, S. Amoretti, Greta Masini , et al. · 2023

β-Amyloid is one of the main pathological hallmarks of Alzheimer’s disease and plays a major role in synaptic dysfunction. It has been demonstrated that β-amyloid can elicit aberrant excitatory activity in cortical-hippocampal networks, wh…

Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration Open

Annalisa Vetro, Simona Balestrini, Cristiana Pelorosso, Alessio Masi, Sophie Hambleton , et al. · 2022

By converting physical forces into electrical signals or triggering intracellular cascades, stretch-activated ion channels (SACs) allow the cell to respond to osmotic and mechanical stress. Knowledge of the pathophysiological mechanisms un…

Diurnal rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability Open

Enrico Pracucci, Robert H. Graham, Laura Alberio, Gabriele Nardi, Olga Cozzolino , et al. · 2022

Fast synaptic inhibition is a primary determinant of cortical activity patterns, and it is mediated predominantly by ionotropic, chloride-conducting receptors. Consequently, modulation of chloride homeostasis is ideally placed to regulate …

Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex Open

Roberto Cadeddu, Laura J. Mosher, Peter Nordkild, Nilesh W. Gaikwad, Gian Michele Ratto , et al. · 2022

A Superfolder Green Fluorescent Protein-Based Biosensor Allows Monitoring of Chloride in the Endoplasmic Reticulum Open

Kaavian Shariati, Yaohuan Zhang, Simone Giubbolini, Riccardo Parra, Steven Y. Liang , et al. · 2022

Though the concentration of chloride has been measured in the cytoplasm and in secretory granules of live cells, it cannot be measured within the endoplasmic reticulum (ER) due to poor fluorescence of existing biosensors. We developed a fl…

Trehalose Treatment in Zebrafish Model of Lafora Disease Open

Stefania Della Vecchia, Asahi Ogi, Rosario Licitra, Francesca Abramo, Gabriele Nardi , et al. · 2022

Mutations in the EPM2A gene encoding laforin cause Lafora disease (LD), a progressive myoclonic epilepsy characterized by drug-resistant seizures and progressive neurological impairment. To date, rodents are the only available models for s…

Perturbation of Cortical Excitability in a Conditional Model of PCDH19 Disorder Open

Didi Lamers, Silvia Landi, Roberta Mezzena, Laura Baroncelli, Vinoshene Pillai , et al. · 2022

PCDH19 epilepsy (DEE9) is an X-linked syndrome associated with cognitive and behavioral disturbances. Since heterozygous females are affected, while mutant males are spared, it is likely that DEE9 pathogenesis is related to disturbed cell-…

Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex Open

Roberto Cadeddu, Laura J. Mosher, Peter Nordkild, Nilesh W. Gaikwad, Gian Michele Ratto , et al. · 2022

Background and purpose Ample evidence indicates that environmental stress impairs information processing, yet the underlying mechanisms remain partially elusive. We showed that, in several rodent models of psychopathology, the neurosteroid…

Perturbation of cortical excitability in a conditional model of PCDH19 disorder Open

Didi Lamers, Silvia Landi, Roberta Mezzena, Laura Baroncelli, Vinoshene Pillai , et al. · 2022

PCDH19 epilepsy (DEE9) is an X linked epilepsy syndrome associated to cognitive and behavioural disturbances. Unlike in most other X linked diseases, heterozygous females are affected while hemizygous males are spared. It has been proposed…

Diurnal variation in neuronal chloride levels and seizure susceptibility, in neocortex, reflecting changes in activity of chloride-cation-cotransporters Open

Enrico Pracucci, R. Graham, Laura Alberio, Gabriele Nardi, Olga Cozzolino , et al. · 2021

Summary The main inhibitory synaptic currents, gated by gamma-aminobutyric acid (GABA), are mediated by Cl - -conducting channels 1–3 , and are therefore sensitive to changes in the chloride electrochemical gradient. GABAergic activity dic…

Altered Cl <sup>−</sup> homeostasis hinders forebrain GABAergic interneuron migration in a mouse model of intellectual disability Open

Andrea Maset, Luisa Galla, Simona Francia, Olga Cozzolino, Paola Capasso , et al. · 2020

Significance Intellectual disability associated with Oligophrenin 1 (OPHN1) mutation is a neurodevelopmental disorder characterized by a wide range of cognitive and social dysfunction. Here, we dissected the impact of OPHN1 mutation on the…

Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter Open

Francesco Trovato, Riccardo Parra, Enrico Pracucci, Silvia Landi, Olga Cozzolino , et al. · 2020

Genetic mosaicism, a condition in which an organ includes cells with different genotypes, is frequently present in monogenic diseases of the central nervous system caused by the random inactivation of the X-chromosome, in the case of X-lin…

In vivo detection of murine glioblastoma through Raman and reflectance fiber-probe spectroscopies Open

Enrico Baria, Enrico Pracucci, Vinoshene Pillai, Francesco S. Pavone, Gian Michele Ratto , et al. · 2020

Significance: Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults. With a worldwide incidence rate of 2 to 3 per 100,000 people, it accounts for more than 60% of all brain cancers; currently, its 5-y…

Evolution of Epileptiform Activity in Zebrafish by Statistical-Based Integration of Electrophysiology and 2-Photon Ca2+ Imaging Open

Olga Cozzolino, Federico Sicca, Emanuele Paoli, Francesco Trovato, Filippo M. Santorelli , et al. · 2020

The study of sources and spatiotemporal evolution of ictal bursts is critical for the mechanistic understanding of epilepsy and for the validation of anti-epileptic drugs. Zebrafish is a powerful vertebrate model representing an excellent …

A Cre-amplifier to generate and detect genetic mosaics<i>in vivo</i> Open

Francesco Trovato, Riccardo Parra, Enrico Pracucci, Silvia Landi, Olga Cozzolino , et al. · 2019

Cre-Lox manipulation is the gold standard for cell-specific expression or knockout of selected genes. However, it is not unusual to deal with conditions of low Cre expression or transient activation, which can often go undetected by conven…

Transient Cognitive Impairment in Epilepsy Open

Silvia Landi, Luigi Petrucco, Federico Sicca, Gian Michele Ratto · 2019

Impairments of the dialog between excitation and inhibition (E/I) is commonly associated to neuropsychiatric disorders like autism, bipolar disorders and epilepsy. Moderate levels of hyperexcitability can lead to mild alterations of the EE…

Modulation of ERK1/MAPK3 potentiates ERK nuclear signalling, facilitates neuronal cell survival and improves memory in mouse models of neurodegenerative disorders Open

Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale , et al. · 2018

Cell signalling mechanisms are central to neuronal activity and their dysregulation may lead to neurodegenerative processes and associated cognitive decline. So far, a major effort has been directed toward the dissection of disease specifi…

Perineuronal nets control visual input via thalamic recruitment of cortical PV interneurons Open

Giulia Faini, Andrea Aguirre, Silvia Landi, Didi Lamers, Tommaso Pizzorusso , et al. · 2018

In the neocortex, critical periods (CPs) of plasticity are closed following the accumulation of perineuronal nets (PNNs) around parvalbumin (PV)-positive inhibitory interneurons. However, how PNNs tune cortical function and plasticity is u…

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