Giancarlo Morelli
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View article: Evaluation of cationic peptide-based nanogels as delivery systems for negatively charged molecules: a formulative study
Evaluation of cationic peptide-based nanogels as delivery systems for negatively charged molecules: a formulative study Open
View article: Evaluation of cationic peptide-based nanogels as delivery systems for negatively charged molecules: a formulative study
Evaluation of cationic peptide-based nanogels as delivery systems for negatively charged molecules: a formulative study Open
Peptide-based nanogels (NGs) represent a cutting-edge class of nanoscale drug delivery systems. Due to their structural properties, NGs platforms can encapsulate and protect therapeutic agents ( e.g. peptides, proteins, and nucleic acids),…
View article: [68Ga]Ga-interleukin-2 for imaging activated T-lymphocytes: biochemical characterization and phase I study in normal subjects
[68Ga]Ga-interleukin-2 for imaging activated T-lymphocytes: biochemical characterization and phase I study in normal subjects Open
Purpose This study aimed to develop a ready-to-use kit for 68 Ga-labelling of interleukin-2 (IL2) facilitating PET imaging of activated T-lymphocytes. Methods Human recombinant IL2 (hrIL2) and Aldesleukin (desIL2), conjugated with two diff…
View article: Poly-L-Lysine doped FmocFF Nanogels as delivery platforms for siRNA
Poly-L-Lysine doped FmocFF Nanogels as delivery platforms for siRNA Open
View article: Structural and functional characterization of self-assembling fragments identified from the transthyretin amyloid-like structure
Structural and functional characterization of self-assembling fragments identified from the transthyretin amyloid-like structure Open
An integrated computational–experimental pipeline identifies peptide fragments from the PDB that self-assemble into cross-β nanostructures with tunable functional properties, enabling bioinspired material design.
View article: Fluorescence of Aggregated Aromatic Peptides for Studying the Kinetics of Aggregation and Hardening of Amyloid‐like Structures
Fluorescence of Aggregated Aromatic Peptides for Studying the Kinetics of Aggregation and Hardening of Amyloid‐like Structures Open
The capability of amyloid‐like peptide fibers to emit intrinsic‐fluorescence enables the study of their formation, stability and hardening through time‐resolved fluorescence analysis, without the need for additional intercalating dyes. Thi…
View article: Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells and diagnostic applications
Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells and diagnostic applications Open
View article: Fmoc-FF hydrogels and nanogels for improved and selective delivery of Dexamethasone in leukemic cells and diagnostic applications
Fmoc-FF hydrogels and nanogels for improved and selective delivery of Dexamethasone in leukemic cells and diagnostic applications Open
Dexamethasone (DEX) is a synthetic cortisol used for the treatment of different pathological states, thus comprising cancer, ocular disorders, and COVID-19 infection. Its clinical use is hampered by the low solubility and severe side effec…
View article: Self-Assembled Materials Based on Fully Aromatic Peptides: The Impact of Tryptophan, Tyrosine, and Dopa Residues
Self-Assembled Materials Based on Fully Aromatic Peptides: The Impact of Tryptophan, Tyrosine, and Dopa Residues Open
Peptides are able to self-organize in structural elements including cross-β structures. Taking advantage of this tendency, in the last decades, peptides have been scrutinized as molecular elements for the development of multivalent supramo…
View article: Ultrashort Cationic Peptide Fmoc-FFK as Hydrogel Building Block for Potential Biomedical Applications
Ultrashort Cationic Peptide Fmoc-FFK as Hydrogel Building Block for Potential Biomedical Applications Open
Fmoc-diphenylalanine (Fmoc-FF) is a low-molecular-weight peptide hydrogelator. This simple all-aromatic peptide can generate self-supporting hydrogel materials, which have been proposed as novel materials for diagnostic and pharmaceutical …
View article: Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines
Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines Open
Introduction: Hydrogel nanoparticles, also known as nanogels (NGs), have been recently proposed as alternative supramolecular vehicles for the delivery of biologically relevant molecules like anticancer drugs and contrast agents. The inner…
View article: Differently N‐Capped Analogues of Fmoc‐FF
Differently N‐Capped Analogues of Fmoc‐FF Open
Short and ultra‐short peptides have been recently envisioned as excellent building blocks for the formulation of hydrogels with appealing properties. Due to its simplicity and capability to gel under physiological conditions, Fmoc‐FF (N α …
View article: Special issue of <i>Journal of Peptide Science</i> dedicated to the 17th Naples <scp>Workshop on Bioactive Peptides</scp> entitled <i>Emerging Peptide Science in 2022</i>
Special issue of <i>Journal of Peptide Science</i> dedicated to the 17th Naples <span>Workshop on Bioactive Peptides</span> entitled <i>Emerging Peptide Science in 2022</i> Open
View article: Incorporation of PEG Diacrylates (PEGDA) Generates Hybrid Fmoc-FF Hydrogel Matrices
Incorporation of PEG Diacrylates (PEGDA) Generates Hybrid Fmoc-FF Hydrogel Matrices Open
Generated by a hierarchical and multiscale self-assembling phenomenon, peptide-based hydrogels (HGs) are soft materials useful for a variety of applications. Short and ultra-short peptides are intriguing building blocks for hydrogel fabric…
View article: Peptide-Based Hydrogels and Nanogels Containing Gd(III) Complexes as T1 Relaxation Agents
Peptide-Based Hydrogels and Nanogels Containing Gd(III) Complexes as T1 Relaxation Agents Open
New peptide-based hydrogels incorporating Gd(III) chelates with different hydration states, molecular structures and overall negative charges ([Gd(BOPTA)]2−), [Gd(DTPA)]2−, and ([Gd(AAZTA)]−) were prepared and characterized. N-terminal Fmo…
View article: Fmoc-Diphenylalanine Hydrogels: Optimization of Preparation Methods and Structural Insights
Fmoc-Diphenylalanine Hydrogels: Optimization of Preparation Methods and Structural Insights Open
Hydrogels (HGs) are tri-dimensional materials with a non-Newtonian flow behaviour formed by networks able to encapsulate high amounts of water or other biological fluids. They can be prepared using both synthetic or natural polymers and th…
View article: Multicomponent Hydrogel Matrices of Fmoc‐FF and Cationic Peptides for Application in Tissue Engineering
Multicomponent Hydrogel Matrices of Fmoc‐FF and Cationic Peptides for Application in Tissue Engineering Open
In the last years, peptide‐based hydrogels are being increasingly used as suitable matrices for biomedical and pharmaceutical applications, including drug delivery and tissue engineering. Recently, the synthesis and the gelation properties…
View article: Solid-state optical properties of self-assembling amyloid-like peptides with different charged states at the terminal ends
Solid-state optical properties of self-assembling amyloid-like peptides with different charged states at the terminal ends Open
The self-assembling of small peptides not only leads to the formation of intriguing nanoarchitectures, but also generates materials with unexpected functional properties. Oligopeptides can form amyloid-like cross-β assemblies that are able…
View article: Preparation and In Vitro Evaluation of RITUXfab-Decorated Lipoplexes to Improve Delivery of siRNA Targeting C1858T PTPN22 Variant in B Lymphocytes
Preparation and In Vitro Evaluation of RITUXfab-Decorated Lipoplexes to Improve Delivery of siRNA Targeting C1858T PTPN22 Variant in B Lymphocytes Open
Autoimmune endocrine disorders, such as type 1 diabetes (T1D) and thyroiditis, at present are treated with only hormone replacement therapy. This emphasizes the need to identify personalized effective immunotherapeutic strategies targeting…
View article: The Introduction of a Cysteine Residue Modulates The Mechanical Properties of Aromatic‐Based Solid Aggregates and Self‐Supporting Hydrogels
The Introduction of a Cysteine Residue Modulates The Mechanical Properties of Aromatic‐Based Solid Aggregates and Self‐Supporting Hydrogels Open
Peptide‐based hydrogels, originated by multiscale self‐assembling phenomenon, have been proposed as multivalent tools in different technological areas. Structural studies and molecular dynamics simulations pointed out the capability of com…
View article: Fluorescence Emission of Self‐assembling Amyloid‐like Peptides: Solution versus Solid State
Fluorescence Emission of Self‐assembling Amyloid‐like Peptides: Solution versus Solid State Open
Analysis of the intrinsic UV‐visible fluorescence exhibited by self‐assembling amyloid‐like peptides in solution and in solid the state highlights that their physical state has a profound impact on the optical properties. In the solid stat…
View article: Amplified spontaneous emission and gain in highly concentrated Rhodamine-doped peptide derivative
Amplified spontaneous emission and gain in highly concentrated Rhodamine-doped peptide derivative Open
View article: Solid-State Optical Properties of Self-Assembling Amyloid-Like Peptides with Different Charged States at the Terminal Ends
Solid-State Optical Properties of Self-Assembling Amyloid-Like Peptides with Different Charged States at the Terminal Ends Open
The self-assembling of small peptides not only leads to the formation of intriguing nanoarchitectures, but also generates materials with unexpected functional properties. Oligopeptides can form amyloid-like cross-β assemblies that are able…
View article: Self-Supporting Hydrogels Based on Fmoc-Derivatized Cationic Hexapeptides for Potential Biomedical Applications
Self-Supporting Hydrogels Based on Fmoc-Derivatized Cationic Hexapeptides for Potential Biomedical Applications Open
Peptide-based hydrogels (PHGs) are biocompatible materials suitable for biological, biomedical, and biotechnological applications, such as drug delivery and diagnostic tools for imaging. Recently, a novel class of synthetic hydrogel-formin…
View article: Amyloid-Like Aggregation in Diseases and Biomaterials: Osmosis of Structural Information
Amyloid-Like Aggregation in Diseases and Biomaterials: Osmosis of Structural Information Open
The discovery that the polypeptide chain has a remarkable and intrinsic propensity to form amyloid-like aggregates endowed with an extraordinary stability is one of the most relevant breakthroughs of the last decades in both protein/peptid…
View article: Peptide-Based Hydrogels and Nanogels for Delivery of Doxorubicin
Peptide-Based Hydrogels and Nanogels for Delivery of Doxorubicin Open
A modulation of the Dox release can be obtained by changing the ratios of the peptide components. The different cellular localization of the drug loaded into HGs and NGs suggests an alternative internalization mechanism. The high DLC, the …
View article: Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers
Fabrication of fluorescent nanospheres by heating PEGylated tetratyrosine nanofibers Open
View article: Antioxidant Effects of PS5, a Peptidomimetic of Suppressor of Cytokine Signaling 1, in Experimental Atherosclerosis
Antioxidant Effects of PS5, a Peptidomimetic of Suppressor of Cytokine Signaling 1, in Experimental Atherosclerosis Open
The chronic activation of the Janus kinase/signal transducer and activator of the transcription (JAK/STAT) pathway is linked to oxidative stress, inflammation and cell proliferation. Suppressors of cytokine signaling (SOCS) proteins negati…
View article: Fluorescence Phenomena in Amyloid and Amyloidogenic Bionanostructures
Fluorescence Phenomena in Amyloid and Amyloidogenic Bionanostructures Open
Nanoscale optical labeling is an advanced bioimaging tool. It is mostly based on fluorescence (FL) phenomena and enables the visualization of single biocells, bacteria, viruses, and biological tissues, providing monitoring of functional bi…
View article: Stable Formulations of Peptide-Based Nanogels
Stable Formulations of Peptide-Based Nanogels Open
Recently, nanogels have been identified as innovative formulations for enlarging the application of hydrogels (HGs) in the area of drug delivery or in diagnostic imaging. Nanogels are HGs-based aggregates with sizes in the range of nanomet…