Gianfranco Fontana
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View article: Structural Modifications at the C3 and C30 Positions of the Lupane Skeleton with Carbon-Centered Nucleophiles
Structural Modifications at the C3 and C30 Positions of the Lupane Skeleton with Carbon-Centered Nucleophiles Open
Lupeol, a naturally occurring pentacyclic triterpenoid widely distributed in various medicinal plants, has attracted significant attention due to its diverse pharmacological properties. In this study, we report the synthesis and structural…
View article: Lavandula pedunculata subsp. atlantica: A Multifunctional Essential Oil for Potentially Combating Microbial Infections and Inflammatory Processes
Lavandula pedunculata subsp. atlantica: A Multifunctional Essential Oil for Potentially Combating Microbial Infections and Inflammatory Processes Open
The genus Lavandula L., belonging to the Lamiaceae family, contains about forty species with a distribution that mainly extends in the Mediterranean basin from the North Atlantic to the Middle East. Due to their excellent biological proper…
View article: Biological Properties of Oleanolic Acid Derivatives Bearing Functionalized Side Chains at C-3
Biological Properties of Oleanolic Acid Derivatives Bearing Functionalized Side Chains at C-3 Open
Triterpene acids are a class of pentacyclic natural carboxylic compounds endowed with a variety of biological activities including antitumor, antimicrobial, and hepatoprotective effects. In this work, several oleanolic acid derivatives wer…
View article: Synthetic Derivatives of Natural ent-Kaurane Atractyligenin Disclose Anticancer Properties in Colon Cancer Cells, Triggering Apoptotic Cell Demise
Synthetic Derivatives of Natural ent-Kaurane Atractyligenin Disclose Anticancer Properties in Colon Cancer Cells, Triggering Apoptotic Cell Demise Open
The antitumor activity of different ent-kaurane diterpenes has been extensively studied. Several investigations have demonstrated the excellent antitumor activity of synthetic derivatives of the diterpene atractyligenin. In this research, …
View article: The Chemistry and the Anti-Inflammatory Activity of Polymethoxyflavonoids from Citrus Genus
The Chemistry and the Anti-Inflammatory Activity of Polymethoxyflavonoids from Citrus Genus Open
Polymethoxyflavonoids (PMFs) are a large group of compounds belonging to the more general class of flavonoids that possess a flavan carbon framework decorated with a variable number of methoxy groups. Hydroxylated polymethoxyflavonoids (HP…
View article: Synthesis, In Vitro and In Silico Analysis of New Oleanolic Acid and Lupeol Derivatives against Leukemia Cell Lines: Involvement of the NF-κB Pathway
Synthesis, In Vitro and In Silico Analysis of New Oleanolic Acid and Lupeol Derivatives against Leukemia Cell Lines: Involvement of the NF-κB Pathway Open
Oleanolic acid (OA) and Lupeol (LU) belong to the class of natural triterpenes and are endowed with a wide range of biological activities, including cytotoxicity toward several cancer cell lines. In this context, we investigated a set of c…
View article: The Orange Peel: An Outstanding Source of Chemical Resources
The Orange Peel: An Outstanding Source of Chemical Resources Open
Citrus sinensis (L.) Osbeck is a very common cultivar belonging to the Rutaceae family. It is largely diffused in several areas of the world characterized by mild to warm climate conditions. Its abundant worldwide production (up to 107 Ton…
View article: A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia
A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia Open
The 2 genera Ballota and Otostegia, belonging to the Lamiaceae family, are closely related taxonomically and found mainly in the Mediterranean area, Middle East, and North Africa. Since ancient times, they have been largely employed in tra…
View article: Chemical Composition of the Essential Oil of <i>Mentha pulegium</i> Growing Wild in Sicily and its Activity on Microorganisms Affecting Historical Art Crafts
Chemical Composition of the Essential Oil of <i>Mentha pulegium</i> Growing Wild in Sicily and its Activity on Microorganisms Affecting Historical Art Crafts Open
The chemical composition of the essential oil from aerial parts of Mentha pulegium L. (Linné) collected in Sicily was evaluated by GC and GC-MS. The main components were pulegone (50.6%), piperitenone (27.8%) and menthone (6.9%). Compariso…
View article: 4′‐置換スピロ[イソインドール‐1,3′‐ピラゾール]誘導体の反応性:置換/脱離反応およびビアリール誘導体へのアクセス
4′‐置換スピロ[イソインドール‐1,3′‐ピラゾール]誘導体の反応性:置換/脱離反応およびビアリール誘導体へのアクセス Open
View article: The Reactivity of 4’-Substituted Spiro[Isoindole-1,3’-pyrazoles] Derivatives: Substitution/Elimination Reactions and Access to Biaryl Derivatives
The Reactivity of 4’-Substituted Spiro[Isoindole-1,3’-pyrazoles] Derivatives: Substitution/Elimination Reactions and Access to Biaryl Derivatives Open
This paper describes aspects of the chemistry of 4’-substituted spiro [indole-1,3’-pyrazoles]. These compounds underwent substitution and/or elimination reactions to afford some new spiro- as well as biaryl derivatives of potential pharmac…