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View article: Supplementary Table S4 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Table S4 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary Table S4
View article: Supplementary Figure legends from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Figure legends from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary figure legends
View article: Supplementary Figures from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Figures from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary Figures 1-4, Tables S1 and S5
View article: Supplementary Table S2 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Table S2 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary Table S2
View article: Supplementary Table S3 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis
Supplementary Table S3 from High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis Open
Supplementary Table S3
View article: Figure S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 2. Transcriptomic characterization of healthy liver and Kupffer cells
View article: Data from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Data from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Early synchronous colorectal liver metastasis (CRLM) represents a clinical condition characterized by the simultaneous presence of primary colorectal cancer and metastatic liver lesions. In this study, we characterized the tissue-specific …
View article: Figure S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 3. Transcriptomic characterization of pathologic and healthy monocytes in the peripheral blood
View article: Figure S5 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S5 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 5. Differences between inflammatory and immunoregulatory TAMs in colon and liver
View article: Table S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table 1. List of significant genes (FDR-adjusted p-value < 0.05, and |Log2-FoldChange| > 0.25, detected in not less than 10% of cells) identified from in each tissue-specific cluster within pathologic colon, liver, and periph…
View article: Table S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table 4. List of genes used to compute the gene module scores related to the cell cycle proliferation score (n genes = 57). Table related to Fig. 5D.
View article: Table S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S3 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table 3. List of significant genes (FDR-adjusted p-value < 0.05, and |Log2-FoldChange| > 0.25, detected in not less than 10% of cells) identified from the comparison Liver vs Colon within the inflammatory or immunoregulatory …
View article: Figure S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S1 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 1. scRNA-sequencing analysis of early phases synchronous CRLM patients
View article: Figure S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Figure S4 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Figure 4. Pseudotime trajectory analysis shows macrophage blood derivation
View article: Table S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Table S2 from Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Supplementary Table S2: List of genes used to compute the gene module scores related to the antigen-presentation (n genes = 24), lipid-associated (n genes = 32), angiogenic (n genes = 31<…
View article: Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver
Tissue-Specific Immunosuppressive and Proliferating Macrophages Fuel Early Metastatic Progression of Human Colorectal Cancer to the Liver Open
Early synchronous colorectal liver metastasis (CRLM) represents a clinical condition characterized by the simultaneous presence of primary colorectal cancer and metastatic liver lesions. In this study, we characterized the tissue-specific …
View article: Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer
Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer Open
Infiltration of macrophages into tumors is a hallmark of cancer progression, and re-educating tumor-associated macrophages (TAMs) toward an antitumor status is a promising immunotherapy strategy. However, the mechanisms through which cance…
View article: Correction: Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics
Correction: Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics Open
View article: Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics
Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics Open
The mechanisms driving immune evasion in early-stage I high-grade serous ovarian carcinoma (HGSOC) remain poorly understood. To investigate this, we performed single-cell RNA-sequencing analysis. Our findings revealed a highly immunosuppre…
View article: The immune cell dynamics in the peripheral blood of cHL patients receiving anti-PD1 treatment
The immune cell dynamics in the peripheral blood of cHL patients receiving anti-PD1 treatment Open
Checkpoint blockade therapy (CBT) involving anti-PD1 antibodies represents the standard approach for cHL patients who do not respond to second-line therapy. Nonetheless, only 20% of relapsed/refractory (R/R) cHL patients treated with CBT a…
View article: Autoimmune-Like Mechanism in Heart Failure Enables Preventive Vaccine Therapy
Autoimmune-Like Mechanism in Heart Failure Enables Preventive Vaccine Therapy Open
BACKGROUND: Heart failure (HF) is strongly associated with inflammation. In pressure overload (PO)–induced HF, cardiac stress triggers adaptive immunity, ablation or inhibition of which blocks disease progression. We hypothesized that PO-H…
View article: C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer
C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer Open
View article: Definition of a Multi-Omics Signature for Esophageal Adenocarcinoma Prognosis Prediction
Definition of a Multi-Omics Signature for Esophageal Adenocarcinoma Prognosis Prediction Open
Esophageal cancer is a highly lethal malignancy, representing 5% of all cancer-related deaths. The two main subtypes are esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). While most research has focused on ESCC…
View article: Definition of a Multi-omics Signature for Esophageal Adenocarcinoma Prognosis Prediction
Definition of a Multi-omics Signature for Esophageal Adenocarcinoma Prognosis Prediction Open
Esophageal cancer is an extremely deadly tumor that accounts for 5% of all cancer deaths. The two main subtypes of the disease are esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). To date, few studies analyse …
View article: The immune cell dynamics in the peripheral blood of cHL patients receiving anti-PD1 treatment
The immune cell dynamics in the peripheral blood of cHL patients receiving anti-PD1 treatment Open
Checkpoint blockade therapy (CBT) involving anti-PD1 antibodies represents the standard approach for cHL patients who do not respond to second-line therapy. Nonetheless, only 20% of relapsed/refractory (R/R) cHL patients treated with CBT a…
View article: Dataset related to article "High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis"
Dataset related to article "High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis" Open
<p>This record contains raw data related to article "High-resolution analysis of mononuclear phagocytes reveals GPNMB as a prognostic marker in human colorectal liver metastasis"</p><p><strong>Abstract</strong>…
View article: Dataset related to article "High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis"
Dataset related to article "High-Resolution Analysis of Mononuclear Phagocytes Reveals GPNMB as a Prognostic Marker in Human Colorectal Liver Metastasis" Open
<p>This record contains raw data related to article "High-resolution analysis of mononuclear phagocytes reveals GPNMB as a prognostic marker in human colorectal liver metastasis"</p><p><strong>Abstract</strong>…
View article: Dataset related to article "Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis"
Dataset related to article "Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis" Open
Dataset related to article "Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis"AbstractHepatic metastasis is a clinical challenge for colorectal cancer (CRC). Senescent cancer cells acc…
View article: Dataset #1 related to article "NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy"
Dataset #1 related to article "NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy" Open
CD8+ T cells control tumors but inevitably become dysfunctional. Ionic metabolism is emerging as a regulator of CD8+ T cells in anti-tumor immunity. We show that sodium chloride (NaCl) counteracts T-cell dysfunction to promote cancer regre…
View article: Dataset #1 related to article "NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy"
Dataset #1 related to article "NaCl enhances CD8+ T-cell effector functions in cancer immunotherapy" Open
CD8+ T cells control tumors but inevitably become dysfunctional. Ionic metabolism is emerging as a regulator of CD8+ T cells in anti-tumor immunity. We show that sodium chloride (NaCl) counteracts T-cell dysfunction to promote cancer regre…