Gianluca Costamagna
YOU?
Author Swipe
View article: Intravenous thrombolysis in patients with acute ischaemic stroke and active cancer (the ITACA-stroke study)
Intravenous thrombolysis in patients with acute ischaemic stroke and active cancer (the ITACA-stroke study) Open
View article: Anticoagulant versus antiplatelet treatment for secondary stroke prevention in patients with active cancer
Anticoagulant versus antiplatelet treatment for secondary stroke prevention in patients with active cancer Open
Background Approximately 5–10% of patients with acute ischemic stroke (AIS) have known active cancer. These patients are at high risk for both recurrent AIS and major bleeding. The optimal antithrombotic strategy for cancer-related stroke …
View article: Unveiling amyotrophic lateral sclerosis complexity: insights from proteomics, metabolomics, and microbiomics
Unveiling amyotrophic lateral sclerosis complexity: insights from proteomics, metabolomics, and microbiomics Open
Amyotrophic lateral sclerosis is the most common motor neuron disease and manifests as a clinically and genetically heterogeneous neurodegenerative disorder mainly affecting the motor systems. To date, despite promising results and accumul…
View article: Apixaban vs Aspirin in Patients With Cancer and Cryptogenic Stroke
Apixaban vs Aspirin in Patients With Cancer and Cryptogenic Stroke Open
Importance Approximately 10% to 15% of ischemic strokes are associated with cancer; cancer-associated stroke, particularly when cryptogenic, is associated with high rates of recurrent stroke and major bleeding. Limited data exist on the sa…
View article: Mortality in acute ischemic stroke patients with new cancer diagnosed during the index hospitalization versus after discharge
Mortality in acute ischemic stroke patients with new cancer diagnosed during the index hospitalization versus after discharge Open
View article: Acute ischaemic stroke in active cancer versus non‐cancer patients: stroke characteristics, mechanisms and clinical outcomes
Acute ischaemic stroke in active cancer versus non‐cancer patients: stroke characteristics, mechanisms and clinical outcomes Open
Background and purpose Demographics, clinical characteristics, stroke mechanisms and long‐term outcomes were compared between acute ischaemic stroke (AIS) patients with active cancer (AC) versus non‐cancer patients. Methods Using data from…
View article: Genomic and transcriptomic advances in amyotrophic lateral sclerosis
Genomic and transcriptomic advances in amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and the most common motor neuron disease. ALS shows substantial clinical and molecular heterogeneity. In vitro and in vivo models coupled with multiomic techniques have pr…
View article: IV Thrombolysis With or Without Endovascular Treatment for Suspected Ischemic Stroke in Patients With Intracranial Tumors
IV Thrombolysis With or Without Endovascular Treatment for Suspected Ischemic Stroke in Patients With Intracranial Tumors Open
In our dataset from routine clinical care, we provide insights on the safety of IVT for suspected ischemic stroke in patients with intracranial tumors, a population that is commonly withheld thrombolysis in clinical practice and prospectiv…
View article: Clinical and Demographic Characteristics, Mechanisms, and Outcomes in Patients With Acute Ischemic Stroke and Newly Diagnosed or Known Active Cancer
Clinical and Demographic Characteristics, Mechanisms, and Outcomes in Patients With Acute Ischemic Stroke and Newly Diagnosed or Known Active Cancer Open
In a comprehensive institutional registry spanning nearly 2 decades, 5.4% of patients with AIS had AC, a quarter of which were diagnosed during or within 12 months after the index stroke hospitalization. Patients with NC had less disabilit…
View article: Advancing Stroke Research on Cerebral Thrombi with Omic Technologies
Advancing Stroke Research on Cerebral Thrombi with Omic Technologies Open
Cerebrovascular diseases represent a leading cause of disability, morbidity, and death worldwide. In the last decade, the advances in endovascular procedures have not only improved acute ischemic stroke care but also conceded a thorough an…
View article: Bridging the Gap: Gene Therapy in a Patient With Spinal Muscular Atrophy Type 1
Bridging the Gap: Gene Therapy in a Patient With Spinal Muscular Atrophy Type 1 Open
Molecular therapies exploit the understanding of pathogenic mechanisms to reconstitute impaired gene function or manipulate flawed RNA expression. These therapies include (1) RNA interference by antisense oligonucleotides, (2) mRNA modific…
View article: Newly Diagnosed Hepatic Encephalopathy Presenting as Non-convulsive Status Epilepticus: A Case Report and Literature Review
Newly Diagnosed Hepatic Encephalopathy Presenting as Non-convulsive Status Epilepticus: A Case Report and Literature Review Open
Background Hepatic encephalopathy is characterized by psychiatric and neurological abnormalities, including epileptic seizure and non-convulsive and convulsive status epilepticus. Conventional brain magnetic resonance imaging is useful in …
View article: A Suspected Case of Cerebral Fat Embolism Triggering a Drug-resistant Status Epilepticus in a HbS/β⁺-Thalassaemia Patient
A Suspected Case of Cerebral Fat Embolism Triggering a Drug-resistant Status Epilepticus in a HbS/β⁺-Thalassaemia Patient Open
Sickle cell disease (SCD) refers to a group of hereditary disorders associated with clinical manifestations of variable severity. C In particular, Fat Embolism Syndrome, a rare and devastating complication of SCD, may preferentially involv…
View article: Impact of <scp>COVID‐19</scp> on the quality of life of patients with neuromuscular disorders in the <scp>L</scp>ombardy area, <scp>I</scp>taly
Impact of <span>COVID‐19</span> on the quality of life of patients with neuromuscular disorders in the <span>L</span>ombardy area, <span>I</span>taly Open
Introduction:/Aims Patients with neuromuscular disorders (NMDs), including many elderly, immunosuppressed, and disabled individuals, may have been particularly affected during the coronavirus disease 2019 (COVID‐19) pandemic in Lombardy, a…
View article: Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids
Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids Open
In the last decade, different research groups in the academic setting have developed induced pluripotent stem cell-based protocols to generate three-dimensional, multicellular, neural organoids. Their use to model brain biology, early neur…
View article: Clinical features and disease course of patients with acute ischaemic stroke just before the Italian index case: Was COVID-19 already there?
Clinical features and disease course of patients with acute ischaemic stroke just before the Italian index case: Was COVID-19 already there? Open
View article: Hyperacute extensive spinal cord infarction and negative spine magnetic resonance imaging: a case report and review of the literature
Hyperacute extensive spinal cord infarction and negative spine magnetic resonance imaging: a case report and review of the literature Open
Rationale: Spinal cord infarction (SCI) accounts for only 1% to 2% of all ischemic strokes and 5% to 8% of acute myelopathies. Magnetic resonance imaging (MRI) holds a role in ruling out non-ischemic etiologies, but the diagnostic accuracy…
View article: Insights into disease mechanisms and potential therapeutics for C9orf72-related amyotrophic lateral sclerosis/frontotemporal dementia
Insights into disease mechanisms and potential therapeutics for C9orf72-related amyotrophic lateral sclerosis/frontotemporal dementia Open
View article: Management of patients with neuromuscular disorders at the time of the SARS-CoV-2 pandemic
Management of patients with neuromuscular disorders at the time of the SARS-CoV-2 pandemic Open
View article: Impact of SARS-CoV-2 pandemic on Neurology trainees in Italy: a resident-driven survey - Supplementary Material
Impact of SARS-CoV-2 pandemic on Neurology trainees in Italy: a resident-driven survey - Supplementary Material Open
Supplementary Materials
View article: Estimating the impact of COVID-19 pandemic on services provided by Italian Neuromuscular Centers: an Italian Association of Myology survey of the acute phase.
Estimating the impact of COVID-19 pandemic on services provided by Italian Neuromuscular Centers: an Italian Association of Myology survey of the acute phase. Open
Overall, COVID-19 pandemic resulted in a significant disruption of clinical and support services for patients with neuromuscular diseases. Despite the efforts to provide telemedicine consults to patients, this option could be promoted and …
View article: Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila
Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila Open
View article: Back to the origins: Human brain organoids to investigate neurodegeneration
Back to the origins: Human brain organoids to investigate neurodegeneration Open
View article: iPSCs-Based Neural 3D Systems: A Multidimensional Approach for Disease Modeling and Drug Discovery
iPSCs-Based Neural 3D Systems: A Multidimensional Approach for Disease Modeling and Drug Discovery Open
Induced pluripotent stem cells (iPSCs)-based two-dimensional (2D) protocols have offered invaluable insights into the pathophysiology of neurological diseases. However, these systems are unable to reproduce complex cytoarchitectural featur…