Explanipedia

Recent Advances in Androgen Receptor Pathway Inhibitors for Castration-Sensitive Prostate Cancer Open

Andrea Lancia, Marco Oderda, Federico Camilli, Eleonora Festa, Marta Bottero , et al. · 2025

Prostate cancer (PCa) is the second most common cancer in men, and it is frequently diagnosed at an advanced stage of the disease. Androgen Deprivation Therapy (ADT) has traditionally represented the backbone of therapy for high-risk, recu…

Early Results from a Randomized Phase II Trial Testing Apalutamide and Stereotactic Body Radiation Therapy for Low-Burden Mhspc (NCT05717660) Open

Giulio Francolini, Mauro Loi, Vanessa Di Cataldo, Pietro Garlatti, Saverio Caini , et al. · 2025

The Evolving Landscape of Novel and Old Biomarkers in Localized High-Risk Prostate Cancer: State of the Art, Clinical Utility, and Limitations Toward Precision Oncology Open

Lilia Bardoscia, Angela Sardaro, M. Quattrocchi, Paola Cocuzza, E. Ciurlia , et al. · 2025

High-risk prostate cancer (PC) accounts for 50–75% of 10-year relapse after primary treatment. Routine clinicopathological parameters for PC patient stratification have proven insufficient to inform clinical decisions in this setting. Tumo…

Acute and late toxicities after moderate hypo-fractionated radiation therapy to the chest wall/breast and regional lymph nodes: a retrospective observational study Open

Simonetta Saldi, Giulia Mascari, Elisabetta Perrucci, Isabella Palumbo, Gianluca Ingrosso , et al. · 2025

The efficacy and safety of hypofractionated regimens were confirmed in real-life settings. Present evidence supports the use of HFRT as standard treatment, providing patients with the advantages of shorter treatment times and reduced healt…

Biology-guided radiotherapy in metastatic prostate cancer: time to push the envelope? Open

Andrea Lancia, Gianluca Ingrosso, Beatrice Detti, Eleonora Festa, Elisabetta Bonzano , et al. · 2024

The therapeutic landscape of metastatic prostate cancer has undergone a profound revolution in recent years. In addition to the introduction of novel molecules in the clinics, the field has witnessed a tremendous development of functional …

Image-guided moderately hypofractionated radiotherapy for localized prostate cancer: a multicentric retrospective study (IPOPROMISE) Open

Gianluca Ingrosso, Elisabetta Ponti, Giulio Francolini, Saverio Caini, S. Fondelli , et al. · 2024

Background Moderate hypofractionated radiotherapy is a treatment option for the cure of localized prostate cancer (PCa) patients based on the results of randomized prospective trials, but there is a clinical concern about the relatively sh…

Stereotactic Body Radiation Therapy and Abiraterone Acetate for Patients Affected by Oligometastatic Castrate-Resistant Prostate Cancer: A Randomized Phase II Trial (ARTO) Open

Giulio Francolini, Andrea Gaetano Allegra, Beatrice Detti, Vanessa Di Cataldo, Saverio Caini , et al. · 2023

PURPOSE ARTO (ClinicalTrials.gov identifier: NCT03449719 ) is a multicenter, phase II randomized clinical trial testing the benefit of adding stereotactic body radiation therapy (SBRT) to abiraterone acetate and prednisone (AAP) in patient…

Modulation of tumor-associated macrophage activity with radiation therapy: a systematic review Open

Carlotta Becherini, Andrea Lancia, Beatrice Detti, Sara Lucidi, Daniele Scartoni , et al. · 2023

Editorial: Reviews in genitourinary oncology Open

Stefano Arcangeli, Andrea Lancia, Gianluca Ingrosso, Luca Triggiani, Anna Wilkins · 2023

EDITORIAL article Front. Oncol., 13 April 2023Sec. Genitourinary Oncology Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1196769

Effect of internal port on dose distribution in post-mastectomy radiotherapy for breast cancer patients after expander breast reconstruction Open

Elisabetta Perrucci, M. Marcantonini, Eleonora Arena, C. Fulcheri, V. Reggioli , et al. · 2023

The port did not significantly affect dose distribution in patients who will receive post-mastectomy radiation therapy.

Choline PET/CT in recurrent prostate cancer Open

Beatrice Detti, Maria Grazia Carnevale, Sara Lucidi, Luca Burchini, Saverio Caini , et al. · 2023

Purpose Biochemical recurrence (BR) occurs in up to 40% of patients with prostate cancer (PCa) treated with primary radical prostatectomy (RP). Choline PET/CT may show, in a single-step examination, the site of tumor recurrence earlier tha…

Impact of total marrow/lymphoid irradiation dose to the intestine on graft-versus-host disease in allogeneic hematopoietic stem cell transplantation for hematologic malignancies Open

Simonetta Saldi, C. Fulcheri, C. Zucchetti, Amr M H Abdelhamid, Alessandra Carotti , et al. · 2022

Background and purpose Graft-versus-host disease (GvHD) is a leading cause of non-relapse mortality in patients undergoing allogeneic hematopoietic stem cell transplantation. The Perugia Bone Marrow Transplantation Unit designed a new cond…

Recommendations for radiation therapy in oligometastatic prostate cancer: An ESTRO-ACROP Delphi consensus Open

Thomas Zilli, Vérane Achard, Alan Dal Pra, Nina Schmidt-Hegemann, Barbara Alicja Jereczek‐Fossa , et al. · 2022

These recommendations have the purpose of providing standardization and consensus to optimize the radiotherapy treatment of oligometastatic prostate cancer until mature results of randomized trials are available.

Editorial: Interaction Between Modern Radiotherapy and Novel Drugs in Prostate Cancer: Future Perspectives Open

Beatrice Detti, Thomas Zilli, Gianluca Ingrosso, Ivone Maria Ribeiro, Andrea Lancia · 2022

EDITORIAL article Front. Oncol., 30 March 2022Sec. Genitourinary Oncology Volume 12 - 2022 | https://doi.org/10.3389/fonc.2022.876318

Stereotactic radiotherapy for lung oligometastases Open

Lorenzo Falcinelli, C. Menichelli, F. Casamassima, Cynthia Aristei, Simona Borghesi , et al. · 2022

30-60% of cancer patients develop lung metastases, mostly from primary tumors in the colon-rectum, lung, head and neck area, breast and kidney. Nowadays, stereotactic radiotherapy (SRT ) is considered the ideal modality for treating pulmon…

Stereotactic or conventional radiotherapy for macroscopic prostate bed recurrence: a propensity score analysis Open

Giulio Francolini, Barbara Alicja Jereczek‐Fossa, Vanessa Di Cataldo, Gabriele Simontacchi, Giulia Marvaso , et al. · 2022

Prognostic Genomic Tissue-Based Biomarkers in the Treatment of Localized Prostate Cancer Open

Gianluca Ingrosso, Emanuele Alì, Simona Marani, Simonetta Saldi, Rita Bellavita , et al. · 2022

In localized prostate cancer clinicopathologic variables have been used to develop prognostic nomograms quantifying the probability of locally advanced disease, of pelvic lymph node and distant metastasis at diagnosis or the probability of…

Stereotactic radiotherapy for brain oligometastases Open

Marco Lupattelli, Paolo Tini, Valerio Nardone, Cynthia Aristei, Simona Borghesi , et al. · 2021

Brain metastases, the most common metastases in adults, will develop in up to 40% of cancer patients, accounting for more than one-half of all intracranial tumors. They are most associated with breast and lung cancer, melanoma and, less fr…

Dose-escalated pelvic radiotherapy for prostate cancer in definitive or postoperative setting Open

Giulio Francolini, G. Stocchi, Beatrice Detti, Vanessa Di Cataldo, Alessio Bruni , et al. · 2021

Radiotherapy at oligoprogression for metastatic castration-resistant prostate cancer patients: a multi-institutional analysis Open

Maurizio Valeriani, Beatrice Detti, Andrei Fodor, Saverio Caini, Simona Borghesi , et al. · 2021

How Has Prostate Cancer Radiotherapy Changed in Italy between 2004 and 2011? An Analysis of the National Patterns-Of-Practice (POP) Database by the Uro-Oncology Study Group of the Italian Society of Radiotherapy and Clinical Oncology (AIRO) Open

Ercole Mazzeo, Luca Triggiani, Luca Frassinelli, Alessia Guarneri, Sara Bartoncini , et al. · 2021

Background and purpose: Two previous “Patterns Of Practice” surveys (POP I and POP II), including more than 4000 patients affected by prostate cancer treated with radical external beam radiotherapy (EBRT) between 1980 and 2003, established…

Upfront metastasis-directed therapy in oligorecurrent prostate cancer does not decrease the time from initiation of androgen deprivation therapy to castration resistance Open

Luca Triggiani, Rosario Mazzola, Davide Tomasini, Alessio Bruni, G. Alicino , et al. · 2021

Breakdown of Symbiosis in Radiation-Induced Oral Mucositis Open

Gianluca Ingrosso, Simonetta Saldi, Simona Marani, Alicia Y. W. Wong, Matteo Bertelli , et al. · 2021

Oral mucositis is an acute side effect of radiation therapy that is especially common with head and neck cancer treatment. In recent years, several studies have revealed the predisposing factors for mucositis, leading to the pre-treatment …

Personalization in Modern Radiation Oncology: Methods, Results and Pitfalls. Personalized Interventions and Breast Cancer Open

Cynthia Aristei, Elisabetta Perrucci, Emanuele Alì, Fabio Marazzi, Valeria Masiello , et al. · 2021

Breast cancer, the most frequent malignancy in women worldwide, is a heterogeneous group of diseases, characterized by distinct molecular aberrations. In precision medicine, radiation oncology for breast cancer aims at tailoring treatment …

Haploidentical age-adapted myeloablative transplant and regulatory and effector T cells for acute myeloid leukemia Open

Antonio Pierini, Loredana Ruggeri, Alessandra Carotti, Franca Falzetti, Simonetta Saldi , et al. · 2021

Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment in eradicating high-risk acute myeloid leukemia (AML). Here, we present data from a novel HLA-haploidentical HSCT protocol that addressed the 2 remai…

Management of prostate cancer radiotherapy during the COVID-19 pandemic: A necessary paradigm change Open

Beatrice Detti, Gianluca Ingrosso, Carlotta Becherini, Andrea Lancia, Emanuela Olmetto , et al. · 2021

In Covid-19 Era, the challenge should concern a correct management of the oncologic patient, reducing the risk of spreading the virus without worsening tumor prognosis.

Stereotactic body radiotherapy for adrenal oligometastasis in lung cancer patients Open

Fabio Arcidiacono, Cynthia Aristei, Alessandro Marchionni, M. Italiani, Cristian Paolo Luca Fulcheri , et al. · 2020

Objective: To report our experience on stereotactic body radiotherapy (SBRT) in adrenal metastases from lung cancer. Methods: 37 oligometastatic lung cancer patients with 38 adrenal metastases submitted to SBRT were retrospectively analyze…

Stereotactic Radiotherapy for Brain Metastases: Imaging Tools and Dosimetric Predictive Factors for Radionecrosis Open

Marco Lupattelli, Emanuele Alì, Gianluca Ingrosso, Simonetta Saldi, C. Fulcheri , et al. · 2020

Radionecrosis (RN) is the most important side effect after stereotactic radiotherapy (SRT) for brain metastases, with a reported incidence ranging from 3% to 24%. To date, there are no unanimously accepted criteria for iconographic diagnos…

Radiotherapy in the era of COVID-19 Open

Andrea Lancia, Elisabetta Bonzano, Marta Bottero, Marta Camici, Francesco Catellani , et al. · 2020

Radiotherapy treatment volumes for oligorecurrent nodal prostate cancer: a systematic review Open

Vérane Achard, Marta Bottero, M. Rouzaud, Andrea Lancia, Marta Scorsetti , et al. · 2020

With a large variability in patterns of practice, the optimal RT strategy remains to be determined in the setting of nodal oligorecurrent PCa. Ongoing randomized trials and advances in translational research will help to shed light on the …

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