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View article: Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium Open
Isogenic bacteria can be phenotypically diverse. This heterogeneity is evident in the Bacteroidota, a predominant phylum of the human gut microbiota. These bacteria adopt diverse morphologies, yet the molecular basis of their morphological…
View article: The global RNA-binding protein RbpB is a regulator of polysaccharide utilization in Bacteroides thetaiotaomicron
The global RNA-binding protein RbpB is a regulator of polysaccharide utilization in Bacteroides thetaiotaomicron Open
View article: An expanded transcriptome atlas for Bacteroides thetaiotaomicron reveals a small RNA that modulates tetracycline sensitivity
An expanded transcriptome atlas for Bacteroides thetaiotaomicron reveals a small RNA that modulates tetracycline sensitivity Open
Plasticity in gene expression allows bacteria to adapt to diverse environments. This is particularly relevant in the dynamic niche of the human intestinal tract; however, transcriptional networks remain largely unknown for gut-resident bac…
View article: CRISPR-based screening of small RNA modulators of bile susceptibility in <i>Bacteroides thetaiotaomicron</i>
CRISPR-based screening of small RNA modulators of bile susceptibility in <i>Bacteroides thetaiotaomicron</i> Open
Microbiota-centric interventions are limited by our incomplete understanding of the gene functions of many of its constituent species. This applies in particular to small RNAs (sRNAs), which are emerging as important regulators in microbio…
View article: The RNA-binding protein RbpB is a central regulator of polysaccharide utilization in gut<i>Bacteroides</i>
The RNA-binding protein RbpB is a central regulator of polysaccharide utilization in gut<i>Bacteroides</i> Open
Paramount to human health, symbiotic bacteria in the gastrointestinal tract rely on the breakdown of complex polysaccharides to thrive in this sugar-deprived environment. Gut Bacteroides are metabolic generalists and deploy dozens of polys…
View article: Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr
Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr Open
View article: A CRISPR-based genetic screen in<i>Bacteroides thetaiotaomicron</i>reveals a small RNA modulator of bile susceptibility
A CRISPR-based genetic screen in<i>Bacteroides thetaiotaomicron</i>reveals a small RNA modulator of bile susceptibility Open
Microbiota-centric interventions are limited by our incomplete understanding of the gene functions of many of its constituent species. This applies in particular to small RNAs (sRNAs), which are emerging as important regulators in microbio…
View article: An integrated transcriptomics–functional genomics approach reveals a small RNA that modulates<i>Bacteroides thetaiotaomicron</i>sensitivity to tetracyclines
An integrated transcriptomics–functional genomics approach reveals a small RNA that modulates<i>Bacteroides thetaiotaomicron</i>sensitivity to tetracyclines Open
Gene expression plasticity allows bacteria to adapt to diverse environments, tie their metabolism to available nutrients, and cope with stress. This is particularly relevant in a niche as dynamic and hostile as the human intestinal tract, …
View article: Comparative genomics provides structural and functional insights into <i>Bacteroides</i> RNA biology
Comparative genomics provides structural and functional insights into <i>Bacteroides</i> RNA biology Open
Bacteria employ noncoding RNA molecules for a wide range of biological processes, including scaffolding large molecular complexes, catalyzing chemical reactions, defending against phages, and controlling gene expression. Secondary structur…
View article: Stockholm sequence-structure alignments for 9 Bacteroides sRNAs
Stockholm sequence-structure alignments for 9 Bacteroides sRNAs Open
Sequence alignment supporting the manuscript "Comparative genomics provides structural and functional insights into Bacteroides RNA biology".
View article: Stockholm sequence-structure alignments for 9 Bacteroides sRNAs
Stockholm sequence-structure alignments for 9 Bacteroides sRNAs Open
Sequence alignment supporting the manuscript "Comparative genomics provides structural and functional insights into Bacteroides RNA biology".
View article: An RNA-centric view on gut Bacteroidetes
An RNA-centric view on gut Bacteroidetes Open
Bacteria employ noncoding RNAs to maintain cellular physiology, adapt global gene expression to fluctuating environments, sense nutrients, coordinate their interaction with companion microbes and host cells, and protect themselves against …
View article: Improved bacterial RNA-seq by Cas9-based depletion of ribosomal RNA reads
Improved bacterial RNA-seq by Cas9-based depletion of ribosomal RNA reads Open
A major challenge for RNA-seq analysis of gene expression is to achieve sufficient coverage of informative nonribosomal transcripts. In eukaryotic samples, this is typically achieved by selective oligo(dT)-priming of messenger RNAs to excl…