Gianluca Selvestrel
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View article: Chemical Mixture Exposures and Their Effects on Sensitisation and Elicitation Responses: A Systematic Review
Chemical Mixture Exposures and Their Effects on Sensitisation and Elicitation Responses: A Systematic Review Open
Consumers and workers are generally exposed to multiple allergens and irritants simultaneously in products. This systematic review of 13 studies: 4 clinical, 6 animal, and 3 in vitro studies, suggests that co‐exposure often enhances both s…
View article: QSAR Models for Predicting the Antioxidant Potential of Chemical Substances
QSAR Models for Predicting the Antioxidant Potential of Chemical Substances Open
Antioxidants are widely studied compounds with significant applications in the nutraceutical and dietary industries. To enable the rapid screening of large libraries of substances for antioxidant activity and to provide a useful tool for t…
View article: Legislation and Current Practices Concerning Risk Assessment of Skin Sensitizers in the European Union: A Comparative and Survey Study
Legislation and Current Practices Concerning Risk Assessment of Skin Sensitizers in the European Union: A Comparative and Survey Study Open
Background Despite legislation aimed to protect the population against skin sensitization in the European Union (EU), over one quarter of the general population is sensitised to at least one chemical. Objectives To provide an overview and …
View article: Computational Tools to Facilitate Early Warning of New Emerging Risk Chemicals
Computational Tools to Facilitate Early Warning of New Emerging Risk Chemicals Open
Innovative tools suitable for chemical risk assessment are being developed in numerous domains, such as non-target chemical analysis, omics, and computational approaches. These methods will also be critical components in an efficient early…
View article: Monte Carlo Models for Sub-Chronic Repeated-Dose Toxicity: Systemic and Organ-Specific Toxicity
Monte Carlo Models for Sub-Chronic Repeated-Dose Toxicity: Systemic and Organ-Specific Toxicity Open
The risk-characterization of chemicals requires the determination of repeated-dose toxicity (RDT). This depends on two main outcomes: the no-observed-adverse-effect level (NOAEL) and the lowest-observed-adverse-effect level (LOAEL). These …
View article: Defining the Human-Biota Thresholds of Toxicological Concern for Organic Chemicals in Freshwater: The Proposed Strategy of the LIFE VERMEER Project Using VEGA Tools
Defining the Human-Biota Thresholds of Toxicological Concern for Organic Chemicals in Freshwater: The Proposed Strategy of the LIFE VERMEER Project Using VEGA Tools Open
Several tons of chemicals are released every year into the environment and it is essential to assess the risk of adverse effects on human health and ecosystems. Risk assessment is expensive and time-consuming and only partial information i…
View article: SpheraCosmolife: a new tool for the risk assessment of cosmetic products
SpheraCosmolife: a new tool for the risk assessment of cosmetic products Open
A new, freely available software for cosmetic products has been designed that considers the regulatory framework for cosmetics. The software allows an overall toxicological evaluation of cosmetic ingredients without the need for additional…
View article: SpheraCosmolife: a new tool for the risk assessment of cosmetic products_suppl
SpheraCosmolife: a new tool for the risk assessment of cosmetic products_suppl Open
A new, freely available software for cosmetic products has been designed that considers the regulatory framework for cosmetics. The software allows an overall toxicological evaluation of cosmetic ingredients without the need for additional…
View article: Idealization of correlations between optimal simplified molecular input-line entry system-based descriptors and skin sensitization
Idealization of correlations between optimal simplified molecular input-line entry system-based descriptors and skin sensitization Open
The Index of Ideality of Correlation (IIC) is a new criterion of the predictive potential for quantitative structure–property/activity relationships. The value of the IIC is a mathematical function sensitive to the value of the correlation…