Gianluca Severi
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View article: Long-term exposure to particulate air pollution and components in relation to breast cancer risk: A nested case-control study in the E3N-Generations cohort
Long-term exposure to particulate air pollution and components in relation to breast cancer risk: A nested case-control study in the E3N-Generations cohort Open
View article: Dealing with differential misclassification of an outcome or a covariate in association studies with an internally validated sample selected not at random.
Dealing with differential misclassification of an outcome or a covariate in association studies with an internally validated sample selected not at random. Open
This methodological framework can be applied in association studies when an imperfect test is used as an indicator of a disease and the disease status has been validated in a subset of the sample. We extended previous works to deal with no…
View article: Association between transportation noise exposure and type 2 diabetes risk in a French prospective cohort: the E3N-generations cohort
Association between transportation noise exposure and type 2 diabetes risk in a French prospective cohort: the E3N-generations cohort Open
View article: Supplementary Figure S1 from Mediating Role of Lifestyle Behaviors in the Association between Education and Cancer: Results from the European Prospective Investigation into Cancer and Nutrition
Supplementary Figure S1 from Mediating Role of Lifestyle Behaviors in the Association between Education and Cancer: Results from the European Prospective Investigation into Cancer and Nutrition Open
Effects (pure direct effect, total indirect effect, and total effect) estimated as function of time to event (years), considering site-specific cancer occurrence as outcome, RelativeIndex of Inequality Tertiles (RIIT) as exposure, age, and…
View article: Data from Mediating Role of Lifestyle Behaviors in the Association between Education and Cancer: Results from the European Prospective Investigation into Cancer and Nutrition
Data from Mediating Role of Lifestyle Behaviors in the Association between Education and Cancer: Results from the European Prospective Investigation into Cancer and Nutrition Open
Background:Many studies have shown that socioeconomic position (SEP) is associated with the incidence of malignant tumors at different sites. This study aims to estimate the association between educational level (as proxy for SEP) and canc…
View article: Table S1, Table S2, Table S3, Table S4, Table S5 from Mediating Role of Lifestyle Behaviors in the Association between Education and Cancer: Results from the European Prospective Investigation into Cancer and Nutrition
Table S1, Table S2, Table S3, Table S4, Table S5 from Mediating Role of Lifestyle Behaviors in the Association between Education and Cancer: Results from the European Prospective Investigation into Cancer and Nutrition Open
Descriptive analyses according to sex and country, Analyses to verify mediation assumptions. Supplementary Table S1 Descriptive analyses of the male EPIC population in terms of demographic, clinical, and risk/protective factors for cancer,…
View article: Data from Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses
Data from Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses Open
Background:Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometria…
View article: Supplementary Table from Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses
Supplementary Table from Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses Open
Supplementary Table from Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses
View article: Supplementary Table from Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses
Supplementary Table from Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses Open
Supplementary Table from Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses
View article: Supplementary Table from Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses
Supplementary Table from Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses Open
Supplementary Table from Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses
View article: Correction: Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood
Correction: Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood Open
[This corrects the article DOI: 10.3389/fpubh.2025.1621495.].
View article: Circulating fatty acid binding protein 4 ( <scp>FABP</scp> ‐4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study
Circulating fatty acid binding protein 4 ( <span>FABP</span> ‐4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study Open
Human fatty acid binding protein‐4 (FABP‐4), a protein elevated in obesity that promotes colon cancer cell invasiveness and metastasis, may be associated with higher mortality in individuals with colorectal cancer (CRC) and may serve as a …
View article: Use of Systemic Glucocorticoids and Risk of Prostate Adenocarcinoma: Evidence From a Danish Population‐Based Case–Control Study
Use of Systemic Glucocorticoids and Risk of Prostate Adenocarcinoma: Evidence From a Danish Population‐Based Case–Control Study Open
Background Glucocorticoids may promote prostate cancer by reducing apoptosis and the immune response, or prevent it by reducing inflammation, inhibiting androgens, and limiting cell proliferation. However, epidemiological evidence is limit…
View article: Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood
Serum levels of per- and polyfluoroalkylated substances and methylation of DNA from peripheral blood Open
Background Perfluorooctanoic acid (PFOA) and Perfluorooctane sulfonate (PFOS) are among numerous chemicals in the Per- and polyfluoroalkylated substances (PFAS) group, which are commonly present in various consumer and industrial products.…
View article: Impact of Hypertension on Cancer Stage at Diagnosis Among French Women: The <scp>E3N</scp> Prospective Cohort
Impact of Hypertension on Cancer Stage at Diagnosis Among French Women: The <span>E3N</span> Prospective Cohort Open
Introduction Hypertension may delay the detection of metastatic cancers. We investigated the association between incident hypertension and the risk of metastatic onset among female cancer patients. We studied notably the role of anti‐hyper…
View article: Alcohol consumption and DNA methylation: an epigenome-wide association study within the French E3N cohort
Alcohol consumption and DNA methylation: an epigenome-wide association study within the French E3N cohort Open
View article: Ingestion of titanium dioxide as an excipient in medicines and the risk of cancer: a nationwide study within the French National health data system
Ingestion of titanium dioxide as an excipient in medicines and the risk of cancer: a nationwide study within the French National health data system Open
View article: Depression, antidepressant use, and breast cancer incidence: results from the <scp>E3N</scp> prospective cohort
Depression, antidepressant use, and breast cancer incidence: results from the <span>E3N</span> prospective cohort Open
Aim Depression and antidepressant drugs may both impact breast cancer incidence, potentially in opposite directions. The few epidemiological studies attempting to disentangle their effects have been inconclusive. We aimed to assess within …
View article: Association Between Hormonal Factors and Risk of Lung and Upper Aerodigestive Tract Cancer in French Women: The <scp>E3N</scp> Prospective Cohort Study
Association Between Hormonal Factors and Risk of Lung and Upper Aerodigestive Tract Cancer in French Women: The <span>E3N</span> Prospective Cohort Study Open
Background Significant sex disparities exist in the incidence of lung and upper aero‐digestive tract (UADT) cancers. Inverse relationships have often been observed between exposure to hormonal factors and these cancers. Data from epidemiol…
View article: POS0226 BIRTHPRINTS: CAN PERINATAL EXPOSURES SHAPE THE FUTURE RISK OF RHEUMATOID ARTHRITIS
POS0226 BIRTHPRINTS: CAN PERINATAL EXPOSURES SHAPE THE FUTURE RISK OF RHEUMATOID ARTHRITIS Open
View article: Symptoms and pathophysiology of post-acute sequelae following COVID-19 (PASC): a cohort study
Symptoms and pathophysiology of post-acute sequelae following COVID-19 (PASC): a cohort study Open
View article: Dietary intake of polycyclic aromatic hydrocarbons (PAHs) and breast cancer risk: Evidence from the French E3N-Generations prospective cohort
Dietary intake of polycyclic aromatic hydrocarbons (PAHs) and breast cancer risk: Evidence from the French E3N-Generations prospective cohort Open
View article: Supplementary Table 3 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 3 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 3 shows the number of cancer cases and controls in the Mendelian randomization study of genetic liability to allergic diseases and asthma-related phenotypes and risk of colorectal cancer.
View article: Supplementary Table 5 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 5 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 5 shows the Mendelian randomization estimates for the potential causal effect of genetic liability to allergic diseases on white blood cells.
View article: Supplementary Table 4 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 4 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 4 shows the genome-wide significant variants related to (a) allergic diseases (asthma, hay fever, or eczema), (b) early-onset asthma, (c) later-onset asthma, (d) atopic asthma, and (e) hay fever or eczema and their asso…
View article: Supplementary Table 1 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 1 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 1 shows summary-level genetic association data of genetic liability to allergic diseases and colorectal cancer.
View article: Data from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Data from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Background:The tumor immunosurveillance theory supports that allergic conditions could decrease cancer risk. However, observational evidence yielded inconsistent results for the association between allergic diseases and colorectal cancer r…
View article: Supplementary Table 2 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 2 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 2 shows the genetic variant overlap (same variants or variants in LD R2>0.001 between exposures) for the three exposures tested in our Mendelian randomization analyses (i.e., genetic liability to allergic diseases and t…
View article: Supplementary Figure 1 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Figure 1 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Figure 1 shows the graphical representation of the hypothesized mediating role of white blood cells in the association between allergic diseases and colorectal cancer risk.
View article: Supplementary Table 7 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study
Supplementary Table 7 from Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study Open
Supplementary Table 7 shows the Mendelian randomization estimates for the potential causal effect of genetic liability to allergic diseases and asthma on colorectal cancer risk; leave one genetic variant out sensitivity analyses.