Gianluigi Condorelli
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View article: 787 RORγ bridges cancer-driven lipid dysmetabolism and myeloid immunosuppression
787 RORγ bridges cancer-driven lipid dysmetabolism and myeloid immunosuppression Open
View article: Predicting procedural outcomes in transcatheter aortic valve implantation: a scoping review of numerical patient-specific simulations
Predicting procedural outcomes in transcatheter aortic valve implantation: a scoping review of numerical patient-specific simulations Open
Transcatheter aortic valve implantation (TAVI)-related post-operative complications remain significant clinical challenges, and current in-silico simulations fall short in predicting them accurately, limiting their clinical applicability. …
View article: Impact of an intensive follow up program on the outcome of acute heart failure patients hospitalized in internal medicine versus cardiology units
Impact of an intensive follow up program on the outcome of acute heart failure patients hospitalized in internal medicine versus cardiology units Open
Background This study evaluates the efficacy of a post-discharge follow-up program in patients recovering from acute heart failure (AHF) hospitalized in internal medicine (IM) and in cardiology (CA) wards. Methods Patients hospitalized for…
View article: Clinical outcomes of percutaneous coronary interventions after transcatheter aortic valve replacement
Clinical outcomes of percutaneous coronary interventions after transcatheter aortic valve replacement Open
Aims The number of patients undergoing percutaneous coronary interventions (PCI) after transcatheter aortic valve replacement (TAVR) is expected to increase, but their prognosis remains poorly understood. Methods and results Consecutive PC…
View article: Reticulated platelets in coronary artery disease: a multidimensional approach unveils prothrombotic signalling and novel therapeutic targets
Reticulated platelets in coronary artery disease: a multidimensional approach unveils prothrombotic signalling and novel therapeutic targets Open
Background and Aims Reticulated platelets (RPs), hyperreactive and RNA-rich, are associated with increased risk of cardiovascular events and suboptimal response to antiplatelet therapy in coronary artery disease (CAD). However, the underly…
View article: Subclinical myocardial impairment in treatment-naive cancer patients assessed by cardiac magnetic resonance
Subclinical myocardial impairment in treatment-naive cancer patients assessed by cardiac magnetic resonance Open
Background Functional and myocardial tissue modifications can occur in treatment-naïve cancer patients naive, driven by uncontrolled inflammation and neuro-hormonal activation. These mechanisms may result in myocardial alterations that ser…
View article: Single-cell RNA sequencing of platelets: challenges and potential
Single-cell RNA sequencing of platelets: challenges and potential Open
Platelets are small, anuclear cells crucial for hemostasis, coagulation, immune responses, and vascular diseases. While unable to produce their own RNA, platelets inherit RNA from their megakaryocyte precursors, exchange RNA with other cel…
View article: Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension
Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension Open
Our findings revealed that both ventricles showed structural remodeling but only the RV underwent electromechanical alteration, while the LV displayed metabolic and inflammatory alteration. This was further validated by the preserved EF in…
View article: Figure S3 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Figure S3 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Cholesterol levels modulate cancer-driven myeloid immunosuppression
View article: Figure S8 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Figure S8 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Myeloid-specific genetic deletion of RORγ regulates tumor-promoting immunosuppressive myelopoiesis
View article: Data from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Data from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Despite well-documented metabolic and hematopoietic alterations during tumor development, the mechanisms underlying this crucial immunometabolic intersection remain elusive. Of particular interest is the connection between lipid metabolism…
View article: Table S2 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Table S2 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Statistical analysis of flow cytometry data of blood PBMC from NSCLC patients. Related to Figure 5B
View article: Table S4 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Table S4 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Murine antibodies for flow cytometry analysis
View article: Table S5 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Table S5 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Human antibodies for flow cytometry analysis
View article: Figure S1 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Figure S1 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Hypercholesterolemia exacerbates cancer-induced alterations in cholesterol metabolism
View article: Figure S2 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Figure S2 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Hypercholesterolemia exacerbates cancer progression and shapes the immunosuppressive myeloid compartment
View article: Figure S10 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Figure S10 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Blockade of cholesterol-RORγ axis restrains tumor progression and myeloid cell immunosuppressive functions
View article: Figure S11 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Figure S11 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Flow cytometry gating strategis. Related to Methods
View article: Figure S7 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Figure S7 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
RORγ deficiency limits the effects of cholesterol on both immunosuppressive activity and myeloid cell maturation
View article: Table S1 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Table S1 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Statistical analysis relative to the heatmap graphs of Figures 2C, S1A, S1E and S1L
View article: Figure S5 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Figure S5 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
IL-6/IL-1β-PCSK9-cholesterol axis regulates RORγ expression in myeloid cells
View article: Figure S6 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Figure S6 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
RORγ couples hypercholesterolemia to protumoral myelopoiesis
View article: Figure S9 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Figure S9 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
RORγ acts as a cholesterol sensor and modulator of myeloid cell immunosuppressive functions
View article: Table S3 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Table S3 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Detailed information about the patients used in the study.
View article: Figure S4 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
Figure S4 from RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Hypercholesterolemia induces bone marrow myelopoiesis, CMPs to GMPs transition, and CSF-1/CSF-1R and CCL2/CCR2 axes
View article: Timing of Cardiac Resynchronization Therapy Following Stable Medical Therapy in Patients With Heart Failure
Timing of Cardiac Resynchronization Therapy Following Stable Medical Therapy in Patients With Heart Failure Open
Time from the achievement of SMT to CRT implantation decreased over the study period. Delayed CRT implantation beyond 3 months was associated with higher cardiovascular mortality compared with earlier implantation after GDMT optimization.
View article: Perioperative management of transcatheter aortic valve implantation in acquired von Willebrand syndrome secondary to monoclonal gammopathy: a case report
Perioperative management of transcatheter aortic valve implantation in acquired von Willebrand syndrome secondary to monoclonal gammopathy: a case report Open
Background Acquired von Willebrand syndrome (AvWS) is a rare bleeding disorder associated with conditions like monoclonal gammopathy of undetermined significance (MGUS). It results from monoclonal antibodies binding to von Willebrand facto…
View article: Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts
Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts Open
Background Bypass surgery using saphenous vein (SV) grafts is commonly performed to revascularize the ischemic heart and lower limbs. These interventions have limited success due to adverse remodeling caused by overproliferation of smooth …
View article: Percutaneous Atrioventricular Valve Repair With MitraClip in Failed Adult Fontan Circulation for Tricuspid Atresia
Percutaneous Atrioventricular Valve Repair With MitraClip in Failed Adult Fontan Circulation for Tricuspid Atresia Open
View article: RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression
RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression Open
Despite well-documented metabolic and hematopoietic alterations during tumor development, the mechanisms underlying this crucial immunometabolic intersection remain elusive. Of particular interest is the connection between lipid metabolism…