Gianna Hirth
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View article: Mechanism and regulation of secondary immunoglobulin diversification
Mechanism and regulation of secondary immunoglobulin diversification Open
Secondary immunoglobulin diversification by somatic hypermutation and class switch recombination in B cells is instrumental for an adequate adaptive humoral immune response. These genetic events may, however, also introduce aberrations int…
View article: Cell Cycle–Mediated Regulation of Secondary Ig Diversification
Cell Cycle–Mediated Regulation of Secondary Ig Diversification Open
Secondary Ig diversification in B cells requires the deliberate introduction of DNA damage into the Ig genes by the enzyme activation-induced cytidine deaminase (AID) and the error-prone resolution of AID-induced lesions. These processes m…
View article: Regulation of the Germinal Center Reaction and Somatic Hypermutation Dynamics by Homologous Recombination
Regulation of the Germinal Center Reaction and Somatic Hypermutation Dynamics by Homologous Recombination Open
During somatic hypermutation (SHM) of Ig genes in germinal center B cells, lesions introduced by activation-induced cytidine deaminase are processed by multiple error-prone repair pathways. Although error-free repair by homologous recombin…