Gianni Marone
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View article: Effects of Advanced Glycation End Products (AGEs) on Human Lung Macrophages: Implications for Pulmonary Inflammation
Effects of Advanced Glycation End Products (AGEs) on Human Lung Macrophages: Implications for Pulmonary Inflammation Open
AGE accumulation promotes a pro-inflammatory phenotype in HLMs, potentially contributing to lung injury and respiratory dysfunction in AGEs-related diseases through the release of pro-inflammatory mediators. These findings highlight HLMs a…
View article: Histamine as a mediator of cross-talk between human lung mast cells and macrophages
Histamine as a mediator of cross-talk between human lung mast cells and macrophages Open
View article: TSLP: contrasting roles in cancer
TSLP: contrasting roles in cancer Open
Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine possessing a plethora of pleiotropic properties. Human and mouse TSLP exerts their activity via a heterodimeric complex composed of TSLP receptor (TSLPR) chain and IL-7Rα. TSLP is …
View article: Differential activation of monocytes and PMNs in orofacial granulomatosis patients induced by bacterial and non-bacterial stimuli
Differential activation of monocytes and PMNs in orofacial granulomatosis patients induced by bacterial and non-bacterial stimuli Open
Introduction Orofacial Granulomatosis (OFG) is a rare chronic inflammatory disorder characterized by persistent or recurrent swelling of the lips and oral mucosa, often accompanied by granulomatous inflammation in the orofacial region with…
View article: Airway epithelial cells as drivers of severe asthma pathogenesis
Airway epithelial cells as drivers of severe asthma pathogenesis Open
View article: TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders
TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders Open
The term alarmin denotes a broad class of molecules rapidly released to alert the immune system through the engagement of specific receptors on immune cells. Three alarmin cytokines-thymic stromal lymphopoietin, IL-33, and IL-25-are releas…
View article: The epithelial era of asthma research: knowledge gaps and future direction for patient care
The epithelial era of asthma research: knowledge gaps and future direction for patient care Open
The Epithelial Science Expert Group convened on 18–19 October 2023, in Naples, Italy, to discuss the current understanding of the fundamental role of the airway epithelium in asthma and other respiratory diseases and to explore the future …
View article: Neutrophil exhaustion and impaired functionality in psoriatic arthritis patients
Neutrophil exhaustion and impaired functionality in psoriatic arthritis patients Open
Background Neutrophils (polymorphonuclear leukocytes, PMNs) are the most abundant subtype of white blood cells and are among the main actors in the inflammatory response. Psoriatic arthritis (PsA) is a chronic inflammatory disease affectin…
View article: The JAK1/JAK2 inhibitor ruxolitinib inhibits mediator release from human basophils and mast cells
The JAK1/JAK2 inhibitor ruxolitinib inhibits mediator release from human basophils and mast cells Open
Introduction The Janus kinase (JAK) family includes four cytoplasmic tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) constitutively bound to several cytokine receptors. JAKs phosphorylate downstream signal transducers and activators of trans…
View article: Altered levels of phospholipases C, diacylglycerols, endocannabinoids, and <i>N</i>‐acylethanolamines in patients with hereditary angioedema due to <scp>FXII</scp> mutation
Altered levels of phospholipases C, diacylglycerols, endocannabinoids, and <i>N</i>‐acylethanolamines in patients with hereditary angioedema due to <span>FXII</span> mutation Open
Background Hereditary angioedema (HAE) is a rare genetic disorder characterized by local, self‐limiting edema due to temporary increase in vascular permeability. HAE with normal C1 esterase inhibitor (C1INH) activity includes the form with…
View article: Mast cells: a novel therapeutic avenue for cardiovascular diseases?
Mast cells: a novel therapeutic avenue for cardiovascular diseases? Open
Mast cells are tissue-resident immune cells strategically located in different compartments of the normal human heart (the myocardium, pericardium, aortic valve, and close to nerves) as well as in atherosclerotic plaques. Cardiac mast cell…
View article: Thymic Stromal Lymphopoietin (TSLP) Is Cleaved by Human Mast Cell Tryptase and Chymase
Thymic Stromal Lymphopoietin (TSLP) Is Cleaved by Human Mast Cell Tryptase and Chymase Open
Thymic stromal lymphopoietin (TSLP), mainly expressed by epithelial cells, plays a central role in asthma. In humans, TSLP exists in two variants: the long form TSLP (lfTSLP) and a shorter TSLP isoform (sfTSLP). Macrophages (HLMs) and mast…
View article: Neutrophil extracellular traps and neutrophil-related mediators in human thyroid cancer
Neutrophil extracellular traps and neutrophil-related mediators in human thyroid cancer Open
Background Polymorphonuclear neutrophils (PMNs) are the main effector cells in inflammatory responses and play multiple roles in thyroid cancer (TC). PMNs contain and release a plethora of mediators, including granular enzymes [e.g., myelo…
View article: Melanoma-derived soluble mediators modulate neutrophil biological properties and the release of neutrophil extracellular traps
Melanoma-derived soluble mediators modulate neutrophil biological properties and the release of neutrophil extracellular traps Open
View article: TSLP mediates bidirectional interactions between human lung macrophages and mast cells
TSLP mediates bidirectional interactions between human lung macrophages and mast cells Open
Background Thymic stromal lymphopoietin (TSLP), a pleiotropic cytokine mainly expressed by epithelial cells, plays a key role in asthma pathobiology. In humans, TSLP exists in two variants: the long form TSLP (lfTSLP) and a shorter TSLP is…
View article: Basophils beyond allergic and parasitic diseases
Basophils beyond allergic and parasitic diseases Open
Basophils bind IgE via FcεRI-αβγ 2, which they uniquely share only with mast cells. In doing so, they can rapidly release mediators that are hallmark of allergic disease. This fundamental similarity, along with some morphological features …
View article: Melanoma-derived soluble mediators modulate neutrophil plasticity and the release of Neutrophil Extracellular Traps
Melanoma-derived soluble mediators modulate neutrophil plasticity and the release of Neutrophil Extracellular Traps Open
Background: polymorphonuclear neutrophils (PMNs) are main effector cells in the inflammatory responses. The significance of PMN infiltration in tumor microenvironment remains to be clarified. Metastatic melanoma is the most lethal type of …
View article: Melanoma-derived soluble mediators modulate neutrophil plasticity and the release of Neutrophil Extracellular Traps
Melanoma-derived soluble mediators modulate neutrophil plasticity and the release of Neutrophil Extracellular Traps Open
Background: polymorphonuclear neutrophils (PMNs) are main effector cells in the inflammatory responses. The significance of PMN infiltration in tumor microenvironment remains to be clarified. Metastatic melanoma is the most lethal type of …
View article: Correction to: Is there a role for microbiome‑based approach in common variable immunodeficiency?
Correction to: Is there a role for microbiome‑based approach in common variable immunodeficiency? Open
View article: Is there a role for microbiome-based approach in common variable immunodeficiency?
Is there a role for microbiome-based approach in common variable immunodeficiency? Open
View article: SARS-CoV-2 Spike Protein Activates Human Lung Macrophages
SARS-CoV-2 Spike Protein Activates Human Lung Macrophages Open
COVID-19 is a viral disease caused by SARS-CoV-2. This disease is characterized primarily, but not exclusively, by respiratory tract inflammation. SARS-CoV-2 infection relies on the binding of spike protein to ACE2 on the host cells. The v…
View article: Basophils from allergy to cancer
Basophils from allergy to cancer Open
Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating leukocytes. While this scarcity long hampered basophil studies, innovations during the past 30 years, beginning with their isolation and more rece…
View article: Human Lung Mast Cells: Therapeutic Implications in Asthma
Human Lung Mast Cells: Therapeutic Implications in Asthma Open
Mast cells are strategically located in different compartments of the lung in asthmatic patients. These cells are widely recognized as central effectors and immunomodulators in different asthma phenotypes. Mast cell mediators activate a wi…
View article: Interplay between C1-inhibitor and group IIA secreted phospholipase A2 impairs their respective function
Interplay between C1-inhibitor and group IIA secreted phospholipase A2 impairs their respective function Open
View article: Neutrophil Extracellular Traps in Asthma: Friends or Foes?
Neutrophil Extracellular Traps in Asthma: Friends or Foes? Open
Asthma is a chronic inflammatory disease characterized by variable airflow limitation and airway hyperresponsiveness. A plethora of immune and structural cells are involved in asthma pathogenesis. The roles of neutrophils and their mediato…
View article: Autoantibodies to IgE can induce the release of proinflammatory and vasoactive mediators from human cardiac mast cells
Autoantibodies to IgE can induce the release of proinflammatory and vasoactive mediators from human cardiac mast cells Open
View article: IgG Autoantibodies Against IgE from Atopic Dermatitis Can Induce the Release of Cytokines and Proinflammatory Mediators from Basophils and Mast Cells
IgG Autoantibodies Against IgE from Atopic Dermatitis Can Induce the Release of Cytokines and Proinflammatory Mediators from Basophils and Mast Cells Open
IgE-mediated release of proinflammatory mediators and cytokines from basophils and mast cells is a central event in allergic disorders. Several groups of investigators have demonstrated the presence of autoantibodies against IgE and/or Fcε…
View article: Differential Effects of Alarmins on Human and Mouse Basophils
Differential Effects of Alarmins on Human and Mouse Basophils Open
Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation. We evaluated the in vitro effects of IL-33, TSLP, and IL…
View article: Angiogenesis, Lymphangiogenesis, and Inflammation in Chronic Obstructive Pulmonary Disease (COPD): Few Certainties and Many Outstanding Questions
Angiogenesis, Lymphangiogenesis, and Inflammation in Chronic Obstructive Pulmonary Disease (COPD): Few Certainties and Many Outstanding Questions Open
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation, predominantly affecting the lung parenchyma and peripheral airways, that results in progressive and irreversible airflow obstruction. COPD development i…
View article: Gender dimorphism in IgA subclasses in T2-high asthma
Gender dimorphism in IgA subclasses in T2-high asthma Open
Immunoglobulin A (Chan in J Allergy Clin Immunol 134:1394–14014e4, 2014), the second most abundant immunoglobulin in serum, plays an important role in mucosal homeostasis. In human serum, there are two subclasses of IgA, IgA1 (≅ 90%) and I…