Gilad Halpert
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View article: Long COVID-19 autoantibodies and their potential effect on fertility
Long COVID-19 autoantibodies and their potential effect on fertility Open
Impaired spermatogenesis has been reported in coronavirus disease 2019 (COVID-19) patients. However, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on male fertility remains unclear. The purpose of this multicen…
View article: Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms
Dysregulated autoantibodies targeting AGTR1 are associated with the accumulation of COVID-19 symptoms Open
View article: Integrative Systems Immunology Analysis Reveals Elevated Anti-AGTR1 Levels with Accumulating COVID-19 Symptoms
Integrative Systems Immunology Analysis Reveals Elevated Anti-AGTR1 Levels with Accumulating COVID-19 Symptoms Open
The coronavirus disease 2019 (COVID-19) displays a broad spectrum of symptoms, with the underlying reasons for this variability still not fully elucidated. Our study investigates the potential association between specific autoantibodies (A…
View article: Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach
Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach Open
View article: Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants
Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants Open
The association between the clinical picture of symptomatic women with silicone breast implants (SBI) and dysregulated immunity was in dispute for decades. In the current study, we describe for the first time the functional activity of pur…
View article: Dysregulated Levels of Circulating Autoantibodies against Neuronal and Nervous System Autoantigens in COVID-19 Patients
Dysregulated Levels of Circulating Autoantibodies against Neuronal and Nervous System Autoantigens in COVID-19 Patients Open
Background: COVID-19 is a heterogenous disease resulting in long-term sequela in predisposed individuals. It is not uncommon that recovering patients endure non-respiratory ill-defined manifestations, including anosmia, and neurological an…
View article: The possible onset of fibromyalgia following acute COVID-19 infection
The possible onset of fibromyalgia following acute COVID-19 infection Open
Introduction The exact pathogenesis of fibromyalgia (FM) syndrome is unclear. However, various infectious have been implicated with the development of FM after their acute phase. We aimed to investigate the incidence of FM syndrome among c…
View article: The Prevalence of Hearing Impairments in Women with Silicone Breast Implants
The Prevalence of Hearing Impairments in Women with Silicone Breast Implants Open
Many women with silicone breast implants (SBIs) report non-specific complaints, including hearing impairments. Hearing impairment appears to be associated with a number of autoimmune conditions. The current study aimed to evaluate the prev…
View article: Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in 2023
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in 2023 Open
In 2011, a syndrome entitled ASIA (Autoimmune/inflammatory Syndrome Induced by Adjuvants; Shoenfeld's syndrome) was first described. ASIA aimed to organize under a single umbrella, the existing evidence regarding certain environmental fact…
View article: Cross‐sectional analysis reveals autoantibody signatures associated with COVID‐19 severity
Cross‐sectional analysis reveals autoantibody signatures associated with COVID‐19 severity Open
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is associated with increased levels of autoantibodies targeting immunological proteins such as cytokines and chemokines. Reports further indicate that COVID‐19 pati…
View article: Injectable, Drug-Eluting Nanocrystals Prevent Fibrosis and Stricture Formation In Vivo
Injectable, Drug-Eluting Nanocrystals Prevent Fibrosis and Stricture Formation In Vivo Open
View article: SARS-CoV-2 infection induces the production of autoantibodies in severe COVID-19 patients in an age-dependent manner
SARS-CoV-2 infection induces the production of autoantibodies in severe COVID-19 patients in an age-dependent manner Open
Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) outcomes due to immunosenescence and certain age-dependent medical conditions (e.g., obesity, cardiovascular disorder, diabetes, chronic respiratory disease). How…
View article: Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19 Open
In patients with severe #COVID19, increased levels of autoantibodies against PAR1 were found. These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute to the pathogenesis of microthr…
View article: Cognitive Impairment, Sleep Disturbance, and Depression in Women with Silicone Breast Implants: Association with Autoantibodies against Autonomic Nervous System Receptors
Cognitive Impairment, Sleep Disturbance, and Depression in Women with Silicone Breast Implants: Association with Autoantibodies against Autonomic Nervous System Receptors Open
Background: Silicone breast implants (SBIs) has been shown to be associated with an increased risk of autoimmune diseases. In the current study, we aimed to explore the potential association between circulating autoantibodies against the a…
View article: Autoantibodies in Females Exposed to Indoor Air Dampness Microbiota and Complaining of Electromagnetic Hypersensitivity- The Case Control Report
Autoantibodies in Females Exposed to Indoor Air Dampness Microbiota and Complaining of Electromagnetic Hypersensitivity- The Case Control Report Open
We hypothesized that prolonged or cumulative exposure to indoor air dampness microbiota in moisture-damaged buildings and daily exposure to wireless telecommunication devices would potentiate the risk of electromagnetic hypersensitivity (E…
View article: Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity
Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity Open
COVID-19 shares the feature of autoantibody production with systemic autoimmune diseases. In order to understand the role of these immune globulins in the pathogenesis of the disease, it is important to explore the autoantibody spectra. He…
View article: Autoantibodies linked to autoimmune diseases associate with COVID-19 outcomes
Autoantibodies linked to autoimmune diseases associate with COVID-19 outcomes Open
The SARS-CoV-2 infection is associated with increased levels of autoantibodies targeting immunological proteins such as cytokines and chemokines. Reports further indicate that COVID-19 patients may develop a wide spectrum of autoimmune dis…
View article: The relationship between autoantibodies targeting GPCRs and the renin-angiotensin system associates with COVID-19 severity
The relationship between autoantibodies targeting GPCRs and the renin-angiotensin system associates with COVID-19 severity Open
The coronavirus disease 2019 (COVID-19) can evolve to clinical manifestations resembling systemic autoimmune diseases, with the presence of autoantibodies that are still poorly characterized. To address this issue, we performed a cross-sec…
View article: Protein synthesis inhibitor omacetaxine is effective against hepatocellular carcinoma
Protein synthesis inhibitor omacetaxine is effective against hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the sixth most common and the fourth most deadly cancer worldwide. The development cost of new therapeutics is a major limitation in patient outcomes. Importantly, there is a paucity of preclinical HCC mod…
View article: The SARS-CoV-2 as an instrumental trigger of autoimmunity
The SARS-CoV-2 as an instrumental trigger of autoimmunity Open
View article: The tellurium-based immunomodulator, AS101 ameliorates adjuvant-induced arthritis in rats
The tellurium-based immunomodulator, AS101 ameliorates adjuvant-induced arthritis in rats Open
Summary Despite undeniable improvement in the management of rheumatoid arthritis (RA), the discovery of more effective, less toxic and, ideally, less immune suppressive drugs are much needed. In the current study, we set to explore the pot…
View article: SARS-CoV-2, the autoimmune virus
SARS-CoV-2, the autoimmune virus Open
View article: Classical Examples of the Concept of the ASIA Syndrome
Classical Examples of the Concept of the ASIA Syndrome Open
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. and encompasses a cluster of related immune mediated diseases, which develop among genetically prone individuals as a result of a…
View article: IVIG ameliorate inflammation in collagen-induced arthritis: projection for IVIG therapy in rheumatoid arthritis
IVIG ameliorate inflammation in collagen-induced arthritis: projection for IVIG therapy in rheumatoid arthritis Open
Summary Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease that leads to joint destruction and disability. Despite a significant progress in administration of biological agents for RA patients, there is still a need fo…
View article: IVIG ameliorate inflammation in collagen induced arthritis- projection for IVIG therapy in rheumatoid arthritis
IVIG ameliorate inflammation in collagen induced arthritis- projection for IVIG therapy in rheumatoid arthritis Open
Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease that leads to joint destruction and disability. Despite a significant progress in administration of biological agents for RA patients, there is still a need for improv…
View article: Dysregulation of G protein-coupled receptors of the autonomic nervous system, adrenergic and muscarinic acetylcholine receptors, in patients with autoimmune dysautonomic-related disorders
Dysregulation of G protein-coupled receptors of the autonomic nervous system, adrenergic and muscarinic acetylcholine receptors, in patients with autoimmune dysautonomic-related disorders Open
View article: Immunomodulation of Murine Chronic DSS-Induced Colitis by Tuftsin–Phosphorylcholine
Immunomodulation of Murine Chronic DSS-Induced Colitis by Tuftsin–Phosphorylcholine Open
Helminths or their products can immunomodulate the host immune system, and this phenomenon may be applied as the basis of new anti-inflammatory treatments. Previously, we have shown the efficacy of tuftsin–phosphorylcholine (TPC), based on…
View article: Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia
Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia Open
Despite its central role in tumor progression and treatment resistance, poor vascularization that necessitates penetration of therapeutics through tumor extracellular matrix (ECM) constitutes a significant challenge to managing tumor hypox…
View article: Local enema treatment to inhibit FOLH1 /GCPII as a novel therapy for inflammatory bowel disease
Local enema treatment to inhibit FOLH1 /GCPII as a novel therapy for inflammatory bowel disease Open
View article: The small tellurium-based compound SAS suppresses inflammation in human retinal pigment epithelium.
The small tellurium-based compound SAS suppresses inflammation in human retinal pigment epithelium. Open
Our results suggest that SAS is a promising anti-inflammatory agent in RPE cells, and may be an effective therapeutic approach for controlling chorioretinal diseases.