Gilbert Ko
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View article: Barriers and facilitators to next-generation sequencing use in United States oncology settings: a systematic review
Barriers and facilitators to next-generation sequencing use in United States oncology settings: a systematic review Open
Aim: Next-generation sequencing (NGS) of solid tumors can inform treatment decisions; however, uptake remains low. This objective of this systematic review was to identify barriers to and facilitators of NGS in US oncology settings.Materia…
View article: Clinical characteristics and treatment patterns of patients with <i>NTRK</i> fusion–positive solid tumors: A multisite cohort study at US academic cancer centers
Clinical characteristics and treatment patterns of patients with <i>NTRK</i> fusion–positive solid tumors: A multisite cohort study at US academic cancer centers Open
This study reports on contemporary real-world NTRK testing patterns and use of TRKis in solid tumors, including time between NTRK testing and initiation of TRKi therapy and duration of TRKi therapy.
View article: Projecting long-term clinical outcomes with larotrectinib compared with immune checkpoint inhibitors in metastatic nonsmall cell lung cancer and differentiated thyroid cancer
Projecting long-term clinical outcomes with larotrectinib compared with immune checkpoint inhibitors in metastatic nonsmall cell lung cancer and differentiated thyroid cancer Open
In metastatic NSCLC and DTC, larotrectinib may produce substantial life expectancy and QALY gains compared to immune checkpoint inhibitors. Additional data with longer follow-up will further inform this comparison.
View article: Next-Generation Sequencing Trends among Adult Patients with Select Advanced Tumor Types
Next-Generation Sequencing Trends among Adult Patients with Select Advanced Tumor Types Open
There are limited data on the prevalence of next-generation sequencing (NGS) in the United States, especially in light of the increasing importance of identifying actionable oncogenic variants due to molecular biomarker-based therapy appro…