Timothy Gilbert
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View article: A Preclinical Model of Human Liver Using Precision Cut Tissue Slice Culture
A Preclinical Model of Human Liver Using Precision Cut Tissue Slice Culture Open
Preclinical models vary in complexity and cost. Traditional 2D cell cultures that are high throughput and cost effective, but lack the complexity of multicellular interactions. Animal models and more complex, but are costly, raise ethical …
View article: Update to the role of staging laparoscopy in the assessment of resectability of perihilar cholangiocarcinoma: have improvements in cross-sectional and functional imaging rendered it redundant?
Update to the role of staging laparoscopy in the assessment of resectability of perihilar cholangiocarcinoma: have improvements in cross-sectional and functional imaging rendered it redundant? Open
Advances in cross-sectional imaging, including FDG PET-CT, have improved radiological staging. However, at 1-in-8, the diagnostic yield of staging laparoscopy remains high, justifying its continued role in evaluating resectability.
View article: Assessment of Scoring Balloons in STEMI Patients Treated With DCB‐Only Angioplasty: A Single Center Study
Assessment of Scoring Balloons in STEMI Patients Treated With DCB‐Only Angioplasty: A Single Center Study Open
Background and Aims A randomized trial has previously demonstrated that neointimal modification with a scoring balloon improves the anti‐restenotic effect of drug‐coated balloon (DCB) in patients with drug‐eluting stent restenosis. There a…
View article: Assessment of Paclitaxel Drug-Coated Balloon-Only Angioplasty for Stent Thrombosis: SPARTAN-ST Study
Assessment of Paclitaxel Drug-Coated Balloon-Only Angioplasty for Stent Thrombosis: SPARTAN-ST Study Open
Background: There are no data regarding the outcomes of patients with stent thrombosis (ST) being treated with drug-coated balloon (DCB) angioplasty. Our aim was to compare the outcomes of patients with ST treated with DCB vs. a drug eluti…
View article: Targeting the tumor microenvironment in cholangiocarcinoma to improve immune checkpoint blockade: potential strategies and translational pre‐clinical models
Targeting the tumor microenvironment in cholangiocarcinoma to improve immune checkpoint blockade: potential strategies and translational pre‐clinical models Open
Cholangiocarcinoma is a malignancy of significant unmet clinical need with limited therapeutic options. Most patients are diagnosed at advanced or metastatic stages, where surgical resection with curative intent is no longer an option. Gem…
View article: Human pressure-volume loops from the impedance catheter: Development and validation of semi-automated beat-by-beat analysis
Human pressure-volume loops from the impedance catheter: Development and validation of semi-automated beat-by-beat analysis Open
Introduction Pressure-volume (PV) loops offer a comprehensive evaluation of cardiac function. Impedance catheters enable the acquisition of synchronised intracardiac electrocardiogram (ECG), pressure, and volume data with high temporal re…
View article: HPB SO07 - Update to the role of staging laparoscopies in stratifying patients by operability in perihilar cholangiocarcinoma
HPB SO07 - Update to the role of staging laparoscopies in stratifying patients by operability in perihilar cholangiocarcinoma Open
Background Radical resection of perihilar cholangiocarcinoma (pCCA) is only an option for the minority presenting at an early stage. Sensitivity of radiological imaging to detect liver and peritoneal metastases is insufficient. Our publish…
View article: The importance of preclinical models in cholangiocarcinoma
The importance of preclinical models in cholangiocarcinoma Open
Cholangiocarcinoma (CCA) is an adenocarcinoma of the hepatobiliary system with a grim prognosis. Incidence is rising globally and surgery is currently the only curative treatment, but is only available for patients who are fit and diagnose…
View article: Preoperative endoscopic biliary drainage by metal versus plastic stents for resectable perihilar cholangiocarcinoma
Preoperative endoscopic biliary drainage by metal versus plastic stents for resectable perihilar cholangiocarcinoma Open
Stent failure was lower in patients with SEMSs as PBD compared with plastic stents in patients with resectable pCCA. Removal during surgery was quite feasible. Surgical outcomes were similar.
View article: Variation in treatment of intrahepatic cholangiocarcinoma: a nationwide multicentre study
Variation in treatment of intrahepatic cholangiocarcinoma: a nationwide multicentre study Open
Journal Article Variation in treatment of intrahepatic cholangiocarcinoma: a nationwide multicentre study Get access Jane McClements, Jane McClements Department of HPB Surgery, Nottingham University Hospitals NHS Trust, Nottingham, UK Sear…
View article: EVALUATION OF SELF-CARE PRACTICE AMONG DIABETIC PATIENTS IN A HOS PITAL IN BAYELSA STATE, NIGERIA
EVALUATION OF SELF-CARE PRACTICE AMONG DIABETIC PATIENTS IN A HOS PITAL IN BAYELSA STATE, NIGERIA Open
Abstract The improvements in the management of diabetes mellitus have been reported by several health articles. However, their health status as it relates to physical, mental, and social status remains a challenge. Self-care in diabetes is…
View article: Oncological Outcomes after Laparoscopic and Open Liver Resection in patients with Colorectal Liver Metastases: A Single Centre Propensity Score Matched Study
Oncological Outcomes after Laparoscopic and Open Liver Resection in patients with Colorectal Liver Metastases: A Single Centre Propensity Score Matched Study Open
Introduction Minimally invasive approaches to oncological liver resection is common in many hepatobiliary centres. This study aims to compare the key oncological and survival outcomes of patients with colorectal liver metastases (CRLM) und…
View article: The incidence and natural history of ascites after liver transplantation
The incidence and natural history of ascites after liver transplantation Open
Background: Ascites is common in cirrhosis but uncommon after liver transplant. We aimed to characterize the incidence, natural history, and current management strategies of post-transplant ascites. Methods: We performed a retrospective co…
View article: Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways
Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways Open
Peri-hilar cholangiocarcinoma (pCCA) is chemorefractory and limited genomic analyses have been undertaken in Western idiopathic disease. We undertook comprehensive genomic analyses of a U.K. idiopathic pCCA cohort to characterize its mutat…
View article: Evaluating Knowledge, Preventive Measures, and Treatment Awareness Regarding Gonorrhea Among Adolescents and Adults in Sagbama, Bayelsa State
Evaluating Knowledge, Preventive Measures, and Treatment Awareness Regarding Gonorrhea Among Adolescents and Adults in Sagbama, Bayelsa State Open
Background of study: Gonorrhea is a sexually transmitted infection caused by the bacterium Neisseria gonorrhoeae. This study aimed to assess the level of knowledge, prevention, and treatment of gonorrhea among those aged 15 – 25 in Sagbama…
View article: HPB P21 Surgery for peri-hilar cholangiocarcinoma: The Liverpool hepatobiliary unit experience
HPB P21 Surgery for peri-hilar cholangiocarcinoma: The Liverpool hepatobiliary unit experience Open
Background Surgery for perihilar cholangiocarcinoma (pCCA) offers the only possibility of long-term survival but remains a formidable undertaking associated with significant post-operative morbidity and mortality. We aim to share our exper…
View article: HPB P07 A propensity matched retrospective study of metal vs plastic stents in the preoperative biliary drainage of patients with resectable perihilar cholangiocarcinoma
HPB P07 A propensity matched retrospective study of metal vs plastic stents in the preoperative biliary drainage of patients with resectable perihilar cholangiocarcinoma Open
Background Preoperative biliary drainage is required in the majority of patients with resectable perihilar cholangiocarcinoma (pCCA). Most centres use plastic stents rather than uncovered self-expanding metal stents (uSEMS) because of the …
View article: Postoperative Packing of Perianal Abscess Cavities (PPAC2): randomized clinical trial
Postoperative Packing of Perianal Abscess Cavities (PPAC2): randomized clinical trial Open
Background Perianal abscess is common. Traditionally, postoperative perianal abscess cavities are managed with internal wound packing, a practice not supported by evidence. The aim of this randomized clinical trial (RCT) was to assess if n…
View article: 39 Drug coated balloon only angioplasty for stable angina in routine clinical practice
39 Drug coated balloon only angioplasty for stable angina in routine clinical practice Open
Introduction The recent BASKETSMALL2 trial demonstrated safety and efficacy of drug coated balloon (DCB) angioplasty for de novo small vessel disease. Registry data have demonstrated that DCB angioplasty is safe; however, the majority of t…
View article: 42 Drug coated balloon only angioplasty for stemi
42 Drug coated balloon only angioplasty for stemi Open
Introduction The main benefit of stenting compared to balloon angioplasty (BA) in the context of ST segment elevation myocardial infarction (STEMI) is to reduce the need for repeat revascularisation rather than myocardial infarction or mor…
View article: O-L02 Evaluation of the Utility of Prognostic Models for Patients Diagnosed with Peri-hilar Cholangiocarcinoma
O-L02 Evaluation of the Utility of Prognostic Models for Patients Diagnosed with Peri-hilar Cholangiocarcinoma Open
Background Several potential prognostic models have been developed to stratify patients with peri-hilar cholangiocarcinoma (PHC) by Overall Survival (OS). The American Joint Committee on Cancer (AJCC) staging system is a post-resectional m…
View article: O-L08 Prognostic value of body morphometrics in patients undergoing surgery for hilar cholangiocarcinoma
O-L08 Prognostic value of body morphometrics in patients undergoing surgery for hilar cholangiocarcinoma Open
Background Hilar cholangiocarcinoma is an aggressive cancer with poor prognosis. Complex pre-operative workup is required prior to major surgery that frequently involves an extended hepatectomy with biliary reconstruction and is associated…
View article: 48 Drug coated balloon only angioplasty for STEMI
48 Drug coated balloon only angioplasty for STEMI Open
Introduction In the setting of primary percutaneous coronary intervention (PPCI), it has been shown that stenting compared to balloon angioplasty (BA) reduces the need for repeat revascularisation but not overall mortality. A recent, small…