Gili Greenbaum
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View article: Integrating gene drives with established pest controls to mitigate spillover risk
Integrating gene drives with established pest controls to mitigate spillover risk Open
Gene drives—artificial genetic constructs that can rapidly spread in a population due to biased inheritance—are a promising tool for controlling disease vectors and invasive species. While gene drives can eradicate target populations withi…
View article: Predicting the direction of phenotypic difference
Predicting the direction of phenotypic difference Open
Predicting phenotypes from genomes is a major goal in genetics, but for most complex phenotypes, predictions are largely inaccurate. Here, we propose a more achievable alternative: relative prediction of phenotypic differences. Even with i…
View article: Genomic signatures of increasing disease burden in recent prehistory
Genomic signatures of increasing disease burden in recent prehistory Open
One of the strongest selection pressures experienced by human populations is that driven by diseases on immune-related genomic regions. While it has been hypothesized for some time that disease burdens increased with the shift to agricultu…
View article: Network-based genetic monitoring of landscape fragmentation
Network-based genetic monitoring of landscape fragmentation Open
Habitat fragmentation is one of the most immediate and substantial threats to biodiversity, generating isolated populations with reduced genetic diversity. Genetic monitoring has become essential for detecting fragmentation and tracking it…
View article: Latitudinal phylogenetic and diversity gradients are explained by a tropical-temperate transitional region
Latitudinal phylogenetic and diversity gradients are explained by a tropical-temperate transitional region Open
The distribution of ecological and evolutionary forces throughout space bring about the patterning of biodiversity. In large geographical areas, this causes the regionalization of biodiversity into structured units known as bioregions. In …
View article: <scp>modelRxiv</scp> : A Platform for the Dissemination and Interactive Display of Models
<span>modelRxiv</span> : A Platform for the Dissemination and Interactive Display of Models Open
Modelling the dynamics of biological processes is ubiquitous across the ecological and evolutionary disciplines. However, the increasing complexity of these models poses a challenge to the dissemination of model‐derived results. Often only…
View article: Unraveling the genomic diversity and admixture history of captive tigers in the United States
Unraveling the genomic diversity and admixture history of captive tigers in the United States Open
Genomic studies of endangered species have primarily focused on describing diversity patterns and resolving phylogenetic relationships, with the overarching goal of informing conservation efforts. However, few studies have investigated gen…
View article: DORA: an interactive map for the visualization and analysis of ancient human DNA and associated data
DORA: an interactive map for the visualization and analysis of ancient human DNA and associated data Open
The ability to sequence ancient genomes has revolutionized the way we study evolutionary history by providing access to the most important aspect of evolution—time. Until recently, studying human demography, ecology, biology, and history u…
View article: Predicting the direction of phenotypic difference
Predicting the direction of phenotypic difference Open
Predicting phenotypes from genomic data is a key goal in genetics, but for most complex phenotypes, predictions are hampered by incomplete genotype-to-phenotype mapping. Here, we describe a more attainable approach than quantitative predic…
View article: Data-driven analyses of social complexity in bees reveal phenotypic diversification following a major evolutionary transition
Data-driven analyses of social complexity in bees reveal phenotypic diversification following a major evolutionary transition Open
How social complexity evolved is a long-standing enigma. In most animal groups, social complexity is typically classified into a few discrete classes. This approach is oversimplified and constrains our inference of social evolution to a na…
View article: DORA: an interactive map for the visualization and analysis of ancient human DNA and associated data
DORA: an interactive map for the visualization and analysis of ancient human DNA and associated data Open
The ability to sequence ancient genomes has revolutionized the way in which we study evolutionary history by providing access to the most important aspect of evolution — time. Until recently, studying human demography, ecology, biology, an…
View article: Acknowledgement to Reviewers of Human Population Genetics and Genomics
Acknowledgement to Reviewers of Human Population Genetics and Genomics Open
View article: Rescue by gene swamping as a gene drive deployment strategy
Rescue by gene swamping as a gene drive deployment strategy Open
Gene drives are genetic constructs that can spread deleterious alleles with potential application to population suppression of harmful species. As gene drives can potentially spill over to other populations or species, control measures and…
View article: Unraveling the Genomic Diversity and Admixture History of Captive Tigers in the United States
Unraveling the Genomic Diversity and Admixture History of Captive Tigers in the United States Open
Genomic studies of rare and endangered species have focused broadly on describing diversity patterns and resolving phylogenetic relationships, with the overarching goal of informing conservation efforts. However, few studies have investiga…
View article: Trait-based approaches to predicting biological control success: challenges and prospects
Trait-based approaches to predicting biological control success: challenges and prospects Open
View article: Rescue by gene swamping as a gene drive deployment strategy
Rescue by gene swamping as a gene drive deployment strategy Open
Gene drives are genetic constructs that can spread deleterious alleles with potential application to population suppression of harmful species. Given that a gene drive can potentially spill over to other populations or even other species, …
View article: Limits to the evolution of dispersal kernels under rapid fragmentation
Limits to the evolution of dispersal kernels under rapid fragmentation Open
Adaptive evolution of dispersal strategies is one mechanism by which species can respond to rapid environmental changes. However, under rapid anthropogenic fragmentation, the evolution of dispersal may be limited, and species may be unable…
View article: modelRxiv: A platform for the dissemination and interactive display of models
modelRxiv: A platform for the dissemination and interactive display of models Open
Modeling the dynamics of biological processes is ubiquitous across the ecological and evolutionary disciplines. However, the increasing complexity of these models poses a significant challenge to the dissemination of model-derived results.…
View article: Extracting hierarchical features of cultural variation using network-based clustering
Extracting hierarchical features of cultural variation using network-based clustering Open
High-dimensional datasets on cultural characters contribute to uncovering insights about factors that influence cultural evolution. Because cultural variation in part reflects descent processes with a hierarchical structure – including the…
View article: Designing gene drives to limit spillover to non-target populations
Designing gene drives to limit spillover to non-target populations Open
The prospect of utilizing CRISPR-based gene-drive technology for controlling populations has generated much excitement. However, the potential for spillovers of gene-drive alleles from the target population to non-target populations has ra…
View article: Recent Evolutionary History of Tigers Highlights Contrasting Roles of Genetic Drift and Selection
Recent Evolutionary History of Tigers Highlights Contrasting Roles of Genetic Drift and Selection Open
Species conservation can be improved by knowledge of evolutionary and genetic history. Tigers are among the most charismatic of endangered species and garner significant conservation attention. However, their evolutionary history and genom…
View article: Network-based hierarchical population structure analysis for large genomic data sets
Network-based hierarchical population structure analysis for large genomic data sets Open
Analysis of population structure in natural populations using genetic data is a common practice in ecological and evolutionary studies. With large genomic data sets of populations now appearing more frequently across the taxonomic spectrum…
View article: Disease transmission and introgression can explain the long-lasting contact zone of modern humans and Neanderthals
Disease transmission and introgression can explain the long-lasting contact zone of modern humans and Neanderthals Open
Neanderthals and modern humans both occupied the Levant for tens of thousands of years prior to the spread of modern humans into the rest of Eurasia and their replacement of the Neanderthals. That the inter-species boundary remained geogra…
View article: Recent evolutionary history of tigers highlights contrasting roles of genetic drift and selection
Recent evolutionary history of tigers highlights contrasting roles of genetic drift and selection Open
Formulating strategies for species conservation requires knowledge of evolutionary and genetic history. Tigers are among the most charismatic of endangered species and garner significant conservation attention. However, the evolutionary hi…
View article: Designing gene drives to limit spillover to non-target populations
Designing gene drives to limit spillover to non-target populations Open
The prospect of utilizing CRISPR-based gene-drive technology for controlling populations, such as invasive and disease-vector species, has generated much excitement. However, the potential for spillovers of gene drive alleles from the targ…
View article: Network-based hierarchical population structure analysis for large genomic datasets
Network-based hierarchical population structure analysis for large genomic datasets Open
Analysis of population structure in natural populations using genetic data is a common practice in ecological and evolutionary studies. With large genomic datasets of populations now appearing more frequently across the taxonomic spectrum,…
View article: Disease and introgression explain the long-lasting contact zone of Modern Humans and Neanderthals and its eventual destabilization
Disease and introgression explain the long-lasting contact zone of Modern Humans and Neanderthals and its eventual destabilization Open
Neanderthals and modern humans both occupied the Levant for tens of thousands of years prior to modern humans’ spread into the rest of Eurasia and their replacement of the Neanderthals. That the inter-species boundary remained geographical…
View article: Issue Information
Issue Information Open
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View article: Detecting hierarchical levels of connectivity in a population of Acacia tortilis at the northern edge of the species’ global distribution: Combining classical population genetics and network analyses
Detecting hierarchical levels of connectivity in a population of Acacia tortilis at the northern edge of the species’ global distribution: Combining classical population genetics and network analyses Open
Genetic diversity and structure of populations at the edge of the species' spatial distribution are important for potential adaptation to environmental changes and consequently, for the long-term survival of the species. Here, we combined …
View article: Revealing life‐history traits by contrasting genetic estimations with predictions of effective population size
Revealing life‐history traits by contrasting genetic estimations with predictions of effective population size Open
Effective population size, a central concept in conservation biology, is now routinely estimated from genetic surveys and can also be theoretically predicted from demographic, life‐history, and mating‐system data. By evaluating the consist…