Explanipedia

Enhanced proteasome activity in perifascicular myofibres is a hallmark of dermatomyositis and its inhibition is efficient in preclinical models Open

L. Debrut, Margherita Giannini, Giulia Quiring, Simone Perniola, Daniela Rovito , et al. · 2025

Enhanced proteasome activity in perifascicular myofibres is a hallmark of DM; its inhibition, deemed effective in preclinical models, may represent a new therapeutic strategy for this disease.

Characterization of the immune landscape in healthy mouse prostate and during prostate cancer progression Open

Despoina Pervizou, Joanna De Chiara, Lionel Spinelli, Maïa Nestor-Martin, Lionel Chasson , et al. · 2025

The immune landscape of healthy prostate and its alterations during prostate cancer (PCa) progression remain poorly characterized. Using scRNA-sequencing and multiparametric flow-cytometry analysis, we comprehensively characterized immune …

Nouvelles perspectives de traitement du cancer de la prostate basé sur la vitamine D Open

Kateryna Len‐Tayon, Daniel Metzger, Gilles Laverny · 2025

Le cancer de la prostate est la troisième cause de mortalité par cancer chez l’homme. L’hormonothérapie et la chimiothérapie sont les traitements de référence pour le cancer de la prostate avancé, mais des résistances surviennent chez la p…

p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment Open

Darya Yanushko, Beatriz German, Rana El Bizri, Despoina Pervizou, Robin Dolgos , et al. · 2025

Prostate cancer is a heterogeneous disease with a slow progression and a highly variable clinical outcome. The tumor suppressor genes PTEN and TP53 are frequently mutated in prostate cancer and are predictive of early metastatic disseminat…

Experimental myositis: an optimised version of C-protein-induced myositis Open

Margherita Giannini, Daniela Rovito, Mustapha Oulad‐Abdelghani, Nadia Messaddeq, L. Debrut , et al. · 2025

Introduction Inflammatory myopathies (IM) are a group of severe autoimmune diseases, sharing some similarities, whose cause is unknown and treatment is empirical. While C-protein-induced myositis (CIM), the most currently used mouse model …

A vitamin D‐based strategy overcomes chemoresistance in prostate cancer Open

Kateryna Len‐Tayon, C Béraud, Constance Fauveau, Anna Y. Belorusova, Yassmine Chebaro , et al. · 2024

Background and purpose Castration‐resistant prostate cancer (CRPC) is a common male malignancy that requires new therapeutic strategies due to acquired resistance to its first‐line treatment, docetaxel. The benefits of vitamin D on prostat…

Experimental myositis: an optimised version of C-protein-induced myositis Open

Margherita Giannini, Daniela Rovito, Mustapha Oulad‐Abdelghani, Nadia Messaddeq, L. Debrut , et al. · 2024

Introduction Inflammatory myopathies (IM) are a group of severe autoimmune diseases, sharing some similarities, whose cause is unknown and treatment is empirical. While C-protein-induced myositis (CIM), the most currently used model of IM,…

4-Hydroxy-1α,25-Dihydroxyvitamin D3: Synthesis and Structure–Function Study Open

Carole Peluso‐Iltis, Noé Pierrat, Daniela Rovito, Judit Ősz, Daisuke Sawada , et al. · 2024

The active vitamin D metabolites, 25-hydroxyvitamin D3 (25D3) and 1,25-dihydroxyvitamin D3 (1,25D3), are produced by successive hydroxylation steps and play key roles in several cellular processes. However, alternative metabolic pathways e…

LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice Open

Qingshuang Cai, Rajesh Sahu, Vanessa Ueberschlag-Pitiot, Sirine Souali‐Crespo, Céline Charvet , et al. · 2024

Synthetic glucocorticoids (GC), such as dexamethasone, are extensively used to treat chronic inflammation and autoimmune disorders. However, long-term treatments are limited by various side effects, including muscle atrophy. GC activities …

Targeting Mitochondrial Dynamics during Lower-Limb Ischemia Reperfusion in Young and Old Mice: Effect of Mitochondrial Fission Inhibitor-1 (mDivi-1) Open

Stéphanie Paradis, Anne‐Laure Charles, Margherita Giannini, Alain Meyer, Anne Lejay , et al. · 2024

Peripheral arterial disease (PAD) strikes more than 200 million people worldwide and has a severe prognosis by potentially leading to limb amputation and/or death, particularly in older patients. Skeletal muscle mitochondrial dysfunctions …

OP0117 PROTEASOME INHIBITION AS A NEW TREATMENT FOR DERMATOMYOSITIS: RESULTS OF A DRUG REPURPOSING ANALYSIS BASED ON THE TRANSCRIPTOMIC SIGNATURE OF PATIENTS' PERIFASCICULAR FIBERS VALIDATED IN PRE-CLINICAL MODELS Open

L. Debrut, Margherita Giannini, Céline Keime, Daniela Rovito, Philippe Mertz , et al. · 2023

OP0119 MUSCLE FIBRE PLAYS A CRUCIAL ROLE IN THE THERAPEUTIC RESPONSE OF MYOSITIS TO GLUCOCORTICOIDS THROUGH THE PARACRINE EFFECT OF EPINEPHRINE ON THE IMMUNE SYSTEM Open

Margherita Giannini, Daniela Rovito, L. Debrut, Régis Lutzing, Anne‐Laure Charles , et al. · 2023

Background Glucocorticoids (GC) are the first line treatment in myositis. GC treatment is empirical. Both GC therapeutic and iatrogenic effects are mediated by the glucocorticoid receptor (GR), which is ubiquitously expressed. Our team has…

Mouse Models of Mineral Bone Disorders Associated with Chronic Kidney Disease Open

Ariane Zaloszyc, Julie Bernardor, Justine Bacchetta, Gilles Laverny, Claus Peter Schmitt · 2023

Patients with chronic kidney disease (CKD) inevitably develop mineral and bone disorders (CKD–MBD), which negatively impact their survival and quality of life. For a better understanding of underlying pathophysiology and identification of …

Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants Open

Anna Y. Belorusova, Daniela Rovito, Yassmine Chebaro, Stefanie Doms, Lieve Verlinden , et al. · 2022

The Vitamin D receptor (VDR) plays a key role in calcium homeostasis, as well as in cell proliferation and differentiation. Among the large number of VDR ligands that have been developed, we have previously shown that BXL-62 and Gemini-72,…

Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression Open

Mohamed A. Abu el Maaty, Julie Terzic, Céline Keime, Daniela Rovito, Régis Lutzing , et al. · 2022

Prostate cancer (PCa) is a leading cause of cancer-related deaths. The slow evolution of precancerous lesions to malignant tumors provides a broad time frame for preventing PCa. To characterize prostatic intraepithelial neoplasia (PIN) pro…

Vitamin D and calcium intakes in general pediatric populations: A French expert consensus paper Open

Justine Bacchetta, Thomas Édouard, Gilles Laverny, Julie Bernardor, Aurélia Bertholet‐Thomas , et al. · 2022

This consensus document was developed to provide guidance to health care professionals on the use of nutritional vitamin D and dietary modalities to achieve the recommended calcium intakes in general pediatric populations. These CPPs will …

Single-cell analyses unravel cell type–specific responses to a vitamin D analog in prostatic precancerous lesions Open

Mohamed A. Abu el Maaty, Élise Grelet, Céline Keime, Anna‐Isavella Rerra, Justine Gantzer , et al. · 2021

Anti- and protumoral effects of a vitamin D analog revealed at single-cell resolution.

Design, Synthesis, Evaluation and Structure of Allenic 1α,25‐Dihydroxyvitamin D<sub>3</sub> Analogs with Locked Mobility at C‐17 Open

Ramón Fraga, Kateryna Len‐Tayon, Régis Lutzing, Gilles Laverny, Julian Loureiro , et al. · 2021

Vitamin D receptor ligands have potential for the treatment of hyperproliferative diseases and disorders related to the immune system. However, hypercalcemic effects limit their therapeutical uses and call for the development of tissue‐sel…

OP0243 AN APPROACH COMBINING TRANSCRIPTOMIC AND TOPOGRAPHIC ANALYSIS REVEALS A POTENTIAL ROLE OF PROTEASOME AND AUTOPHAGY DEREGULATION IN THE PATHOPHYSIOLOGY OF DERMATOMYOSITIS Open

L. Debrut, Gilles Laverny, Pamela Mertz, Margherita Giannini, M. Pizzimenti , et al. · 2021

Myod1 and GR coordinate myofiber-specific transcriptional enhancers Open

Daniela Rovito, Anna‐Isavella Rerra, Vanessa Ueberschlag-Pitiot, Shilpy Joshi, Nezih Karasu , et al. · 2021

Skeletal muscle is a dynamic tissue the size of which can be remodeled through the concerted actions of various cues. Here, we investigated the skeletal muscle transcriptional program and identified key tissue-specific regulatory genetic e…

Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia Open

Daniela Rovito, Anna Y. Belorusova, Sandra Chalhoub, Anna‐Isavella Rerra, Elvire Guiot , et al. · 2020

Aging Exacerbates Ischemia-Reperfusion-Induced Mitochondrial Respiration Impairment in Skeletal Muscle Open

Stéphanie Paradis, Anne‐Laure Charles, Isabelle Georg, Fabienne Goupilleau, Alain Meyer , et al. · 2019

Cycles of ischemia-reperfusion (IR) that occur during peripheral arterial disease (PAD) are associated with significant morbi-mortality, and aging is an irreversible risk factor of PAD. However, the effects of advanced age on IR-induced sk…

PGC-1β modulates statin-associated myotoxicity in mice Open

François Singh, Joffrey Zoll, Urs Duthaler, Anne‐Laure Charles, Miljenko V. Panajatovic , et al. · 2018

Diabetes Worsens Skeletal Muscle Mitochondrial Function, Oxidative Stress, and Apoptosis After Lower-Limb Ischemia-Reperfusion: Implication of the RISK and SAFE Pathways? Open

Julien Pottecher, Chris Adamopoulos, Anne Lejay, Jamal Bouitbir, Anne‐Laure Charles , et al. · 2018

Objectives: Diabetic patients respond poorly to revascularization for peripheral arterial disease (PAD) but the underlying mechanisms are not well understood. We aimed to determine whether diabetes worsens ischemia-reperfusion (IR)-…

Mitochondria: An Organelle of Bacterial Origin Controlling Inflammation Open

Alain Meyer, Gilles Laverny, L. Bernardi, Anne Charles, Ghada Alsaleh , et al. · 2018

Inflammation is a cellular and molecular response to infection and/or tissues injury. While a suited inflammatory response in intensity and time allows for killing pathogens, clearing necrotic tissue, and healing injury; an excessive infla…

Ligand-Independent Actions of Vitamin D Receptor Open

Gilles Laverny, Daniel Metzger · 2017

PGC-1β prevents statin-associated myotoxicity in oxidative skeletal muscle Open

François Singh, Joffrey Zoll, Urs Duthaler, Anne‐Laure Charles, Gilles Laverny , et al. · 2017

Statins are generally well-tolerated, but can induce myopathy. Statins are associated with impaired expression of PGC-1β in human and rat skeletal muscle. The current study was performed to investigate the relation between PGC-1β expressio…

Moderate Exercise Allows for shorter Recovery Time in Critical Limb Ischemia Open

Anne Lejay, Gilles Laverny, Stéphanie Paradis, Anna-Isabel Schlagowski, Anne‐Laure Charles , et al. · 2017

Whether and how moderate exercise might allow for accelerated limb recovery in chronic critical limb ischemia (CLI) remains to be determined. Chronic CLI was surgically induced in mice, and the effect of moderate exercise (training five ti…

Conditional expression of Ki-RasG12V in the mammary epithelium of transgenic mice induces estrogen receptor alpha (ERα)-positive adenocarcinoma Open

Sebastiano Andò, Rocco Malivindi, Stefania Catalano, Pietro Rizza, Ines Barone , et al. · 2017

Androgen signaling negatively controls group 2 innate lymphoid cells Open

Sophie Laffont, Eve Blanquart, Magali Savignac, Claire Cénac, Gilles Laverny , et al. · 2017

Prevalence of asthma is higher in women than in men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) are key regulators of type 2 inflammatory responses. Here, we show that ILC2 development is…

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