Gina M. Warner
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View article: Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity
Ecto-CD38-NADase inhibition modulates cardiac metabolism and protects mice against doxorubicin-induced cardiotoxicity Open
Aims Doxorubicin (DXR) is a chemotherapeutic agent that causes dose-dependent cardiotoxicity. Recently, it has been proposed that the NADase CD38 may play a role in doxorubicin-induced cardiotoxicity (DIC). CD38 is the main NAD+-catabolizi…
View article: p21 induces a senescence program and skeletal muscle dysfunction
p21 induces a senescence program and skeletal muscle dysfunction Open
View article: Low NAD+ Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice
Low NAD+ Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice Open
Advanced paternal age has increasingly been recognized as a risk factor for male fertility and progeny health. While underlying causes are not well understood, aging is associated with a continuous decline of blood and tissue NAD + levels,…
View article: CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging
CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging Open
Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age‐related NAD decline. Whether the inhibition of CD38 increases lifespan is not …
View article: Dihydronicotinamide Riboside Is a Potent NAD+ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages
Dihydronicotinamide Riboside Is a Potent NAD+ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages Open
Nicotinamide adenine dinucleotide (NAD) metabolism plays an important role in the regulation of immune function. However, a complete picture of how NAD, its metabolites, precursors, and metabolizing enzymes work together in regulating immu…
View article: The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions Open
Nicotinamide adenine dinucleotide (NAD) acts as a cofactor in several oxidation-reduction (redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental to a variety of cellular processes including energy metabol…
View article: FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue
FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue Open
View article: A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease
A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease Open
View article: CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels Open
View article: Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis
Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis Open
Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of end-stage renal disease (ESRD). The treatment options for ADPKD are limited. We observed an upregulation in several IGF-1 pathway genes in the kidney …
View article: The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline Open
Tissue nicotinamide adenine dinucleotide (NAD+) decline has been implicated in aging. We have recently identified CD38 as a central regulator involved in tissue NAD+ decline during the aging process. CD38 is an ecto-e…
View article: A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline
A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline Open
View article: CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism Open
View article: Blockade of CCR2 reduces macrophage influx and development of chronic renal damage in murine renovascular hypertension
Blockade of CCR2 reduces macrophage influx and development of chronic renal damage in murine renovascular hypertension Open
Renovascular hypertension (RVH) is a common cause of both cardiovascular and renal morbidity and mortality. In renal artery stenosis (RAS), atrophy in the stenotic kidney is associated with an influx of macrophages and other mononuclear ce…