Gina Savickas
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View article: PHASE 1 STUDY OF PRT1419 (MCL1 INHIBITOR) AS MONOTHERAPY OR IN COMBINATION WITH AZACITIDINE OR VENETOCLAX IN PATIENTS WITH RELAPSED/REFRACTORY MYELOID OR B‐CELL MALIGNANCIES
PHASE 1 STUDY OF PRT1419 (MCL1 INHIBITOR) AS MONOTHERAPY OR IN COMBINATION WITH AZACITIDINE OR VENETOCLAX IN PATIENTS WITH RELAPSED/REFRACTORY MYELOID OR B‐CELL MALIGNANCIES Open
Introduction: PRT1419 is a potent and selective inhibitor of myeloid cell leukemia-1 (MCL-1). MCL-1 is frequently amplified or overexpressed in hematologic malignancies and is associated with higher grade malignancy and poor prognosis (Xia…
View article: Urine Cell Transcriptomes Implicate Specific Renal Inflammatory Pathways Associated With Difficult‐to‐Control Hypertension
Urine Cell Transcriptomes Implicate Specific Renal Inflammatory Pathways Associated With Difficult‐to‐Control Hypertension Open
Background The renal mechanisms involved in the maintenance of human hypertension and resistance to treatment are not well understood. Animal studies suggest that chronic renal inflammation contributes to hypertension. We studied cells she…
View article: COVID-19 Modulates Inflammatory and Renal Markers That May Predict Hospital Outcomes among African American Males
COVID-19 Modulates Inflammatory and Renal Markers That May Predict Hospital Outcomes among African American Males Open
Background and Objectives: African Americans and males have elevated risks of infection, hospitalization, and death from SARS-CoV-2 in comparison with other populations. We report immune responses and renal injury markers in African Americ…
View article: High SARS-CoV-2 Viral Load in Urine Sediment Correlates with Acute Kidney Injury and Poor COVID-19 Outcome
High SARS-CoV-2 Viral Load in Urine Sediment Correlates with Acute Kidney Injury and Poor COVID-19 Outcome Open
Significance statement AKI has been recognized as a common complication of coronavirus disease 2019 (COVID-19) and is associated with disease severity and mortality. The mechanisms behind these associations remain obscure, due, in part, to…