Ginger D. Shaw
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View article: Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection
Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection Open
View article: The updated mouse universal genotyping array bioinformatic pipeline improves genetic QC in laboratory mice
The updated mouse universal genotyping array bioinformatic pipeline improves genetic QC in laboratory mice Open
The MiniMUGA genotyping array is a popular tool for genetic quality control of laboratory mice and genotyping samples from most experimental crosses involving laboratory strains, particularly for reduced complexity crosses. The content of …
View article: The updated mouse universal genotyping array bioinformatic pipeline improves genetic QC in laboratory mice
The updated mouse universal genotyping array bioinformatic pipeline improves genetic QC in laboratory mice Open
The MiniMUGA genotyping array is a popular tool for genetic quality control of laboratory mice and genotyping samples from most experimental crosses involving laboratory strains, particularly for reduced complexity crosses. The content of …
View article: Sarbecovirus disease susceptibility is conserved across viral and host models
Sarbecovirus disease susceptibility is conserved across viral and host models Open
View article: Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans
Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans Open
View article: The Updated Mouse Universal Genotyping Array Bioinformatic Pipeline Improves Genetic QC in Laboratory Mice
The Updated Mouse Universal Genotyping Array Bioinformatic Pipeline Improves Genetic QC in Laboratory Mice Open
The MiniMUGA genotyping array is a popular tool for genetic QC of laboratory mice and genotyping of samples from most types of experimental crosses involving laboratory strains, particularly for reduced complexity crosses. The content of t…
View article: Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection
Unique immune profiles in collaborative cross mice linked to survival and viral clearance upon infection Open
View article: Host Genetic Variation Impacts SARS-CoV-2 Vaccination Response in the Diversity Outbred Mouse Population
Host Genetic Variation Impacts SARS-CoV-2 Vaccination Response in the Diversity Outbred Mouse Population Open
The COVID-19 pandemic led to the rapid and worldwide development of highly effective vaccines against SARS-CoV-2. However, there is significant individual-to-individual variation in vaccine efficacy due to factors including viral variants,…
View article: Host Genetic Variation Impacts SARS-CoV-2 Vaccination Response in the Diversity Outbred Mouse Population
Host Genetic Variation Impacts SARS-CoV-2 Vaccination Response in the Diversity Outbred Mouse Population Open
The COVID-19 pandemic led to the rapid and worldwide development of highly effective vaccines against SARS-CoV-2. However, there is significant individual-to-individual variation in vaccine efficacy due to factors including viral variants,…
View article: Sarbecovirus disease susceptibility is conserved across viral and host models
Sarbecovirus disease susceptibility is conserved across viral and host models Open
Coronaviruses have caused three severe epidemics since the start of the 21 st century: SARS, MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing likelihood of future coronavirus outbreaks motivates greater under…
View article: A mutation in<i>Themis</i>contributes to peanut-induced oral anaphylaxis in CC027 mice
A mutation in<i>Themis</i>contributes to peanut-induced oral anaphylaxis in CC027 mice Open
Background The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut- sensitized CC027/GeniUnc (CC027) mic…
View article: Memory T cells possess an innate-like function in local protection from mucosal infection
Memory T cells possess an innate-like function in local protection from mucosal infection Open
Mucosal infections pose a significant global health burden. Antigen-specific tissue-resident T cells are critical to maintaining barrier immunity. Previous studies in the context of systemic infection suggest that memory CD8+ T cells may a…
View article: Multi-omics analysis identifies drivers of protein phosphorylation
Multi-omics analysis identifies drivers of protein phosphorylation Open
View article: Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis
Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis Open
Variation in immune homeostasis, the state in which the immune system is maintained in the absence of stimulation, is highly variable across populations. This variation is attributed to both genetic and environmental factors. However, the …
View article: Additional file 2 of Multi-omics analysis identifies drivers of protein phosphorylation
Additional file 2 of Multi-omics analysis identifies drivers of protein phosphorylation Open
Additional file 2: Table S1. Information about the 58 CC strains included in this study.
View article: Additional file 6 of Multi-omics analysis identifies drivers of protein phosphorylation
Additional file 6 of Multi-omics analysis identifies drivers of protein phosphorylation Open
Additional file 6: Table S5. Mediation analysis summaries for distant phQTL in three tissues in CC strains.
View article: Additional file 3 of Multi-omics analysis identifies drivers of protein phosphorylation
Additional file 3 of Multi-omics analysis identifies drivers of protein phosphorylation Open
Additional file 3: Table S2. Sex effect for proteins and phosphorylation sites in three tissues in CC strains.
View article: Additional file 5 of Multi-omics analysis identifies drivers of protein phosphorylation
Additional file 5 of Multi-omics analysis identifies drivers of protein phosphorylation Open
Additional file 5: Table S4. pQTL and phQTL summaries for three tissues in CC strains.
View article: Additional file 4 of Multi-omics analysis identifies drivers of protein phosphorylation
Additional file 4 of Multi-omics analysis identifies drivers of protein phosphorylation Open
Additional file 4: Table S3. Heritability of proteins and phosphorylation sites in three tissues in CC strains.
View article: Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis
Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis Open
Variation in immune homeostasis, the state in which the immune system is maintained in the absence of stimulation, is highly variable across populations. This variation is attributed to both genetic and environmental factors. However, the …
View article: Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis
Forward genetic screen of homeostatic antibody levels in the Collaborative Cross identifies MBD1 as a novel regulator of B cell homeostasis Open
Variation in immune homeostasis, the state in which the immune system is maintained in the absence of stimulation, is highly variable across populations. This variation is attributed to both genetic and environmental factors. However, the …
View article: A Multitrait Locus Regulates Sarbecovirus Pathogenesis
A Multitrait Locus Regulates Sarbecovirus Pathogenesis Open
Host genetic variation is an important determinant that predicts disease outcomes following infection. In the setting of highly pathogenic coronavirus infections genetic determinants underlying host susceptibility and mortality remain uncl…
View article: An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice
An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice Open
View article: Multi-omics analysis identifies drivers of protein phosphorylation
Multi-omics analysis identifies drivers of protein phosphorylation Open
Phosphorylation of proteins is a key step in the regulation of many cellular processes including activation of enzymes and signaling cascades. The abundance of a phosphorylated peptide (phosphopeptide) is determined by the abundance of its…
View article: A Multitrait Locus Regulates Sarbecovirus Pathogenesis
A Multitrait Locus Regulates Sarbecovirus Pathogenesis Open
Infectious diseases have shaped the human population genetic structure, and genetic variation influences the susceptibility to many viral diseases. However, a variety of challenges have made the implementation of traditional human Genome-w…
View article: Cocaine-Induced Locomotor Activation Differs Across Inbred Mouse Substrains
Cocaine-Induced Locomotor Activation Differs Across Inbred Mouse Substrains Open
Cocaine use disorders (CUD) are devastating for affected individuals and impose a significant societal burden, but there are currently no FDA-approved therapies. The development of novel and effective treatments has been hindered by substa…
View article: Author response: Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice
Author response: Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract The outcome…
View article: Cocaine-induced locomotor activation differs across six sets of inbred mouse substrains
Cocaine-induced locomotor activation differs across six sets of inbred mouse substrains Open
Cocaine use disorders (CUD) are devastating for affected individuals and impose a significant burden on society, but there are currently no FDA-approved therapies. The development of novel and effective treatments has been hindered by subs…
View article: Regulation of protein abundance in genetically diverse mouse populations
Regulation of protein abundance in genetically diverse mouse populations Open
View article: Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species
Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species Open
Sarbecovirus (CoV) infections, including Severe Acute Respiratory CoV (SARS-CoV) and SARS-CoV-2, are considerable human threats. Human GWAS studies have recently identified loci associated with variation in SARS-CoV-2 susceptibility. Howev…