Gioacchino Tedeschi
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View article: Using Psychophysiological Insights to Evaluate the Impact of Loot Boxes on Arousal
Using Psychophysiological Insights to Evaluate the Impact of Loot Boxes on Arousal Open
This study investigates the psychophysiological effects of loot box interactions in video games and their potential similarities to those recorded during gambling interactions. Using electrodermal activity (EDA) measurements, the research …
View article: No additional benefit with detoxification strategies: A real world experience in 200 patients with chronic migraine and either simple or complex MOH treated with CGRP monoclonal antibodies
No additional benefit with detoxification strategies: A real world experience in 200 patients with chronic migraine and either simple or complex MOH treated with CGRP monoclonal antibodies Open
Background Although withdrawal from analgesics with or without detoxification strategy represented a mainstay in medication overuse headache (MOH) management, recent evidence supports that it is no longer beneficial when CGRP-targeting mon…
View article: Screening of visuospatial abilities in amyotrophic lateral sclerosis (ALS): a pilot study using the battery for visuospatial abilities (BVA)
Screening of visuospatial abilities in amyotrophic lateral sclerosis (ALS): a pilot study using the battery for visuospatial abilities (BVA) Open
Background Cognitive deficits related to frontotemporal dysfunction are common in Amyotrophic Lateral Sclerosis (ALS). Visuospatial deficits, related to posterior cerebral regions, are often underestimated in ALS, though they play a crucia…
View article: Cognitive impairment in kidney transplanted patients
Cognitive impairment in kidney transplanted patients Open
Chronic kidney disease affects almost all of the organs. Recently, more attention has been paid to the kidney and the central nervous system connections. In patients on kidney replacement therapy, including kidney transplantation, there is…
View article: Care pathways for patients with cognitive impairment and chronic kidney disease
Care pathways for patients with cognitive impairment and chronic kidney disease Open
Various epidemiological datasets and pathophysiological hypotheses have highlighted a significant link between chronic kidney disease (CKD) and cognitive impairment (CI); each condition can potentially exacerbate the other. Here, we review…
View article: CONNECT: what has been done and what needs to be done
CONNECT: what has been done and what needs to be done Open
View article: Chemotherapy-related cognitive impairment and kidney dysfunction
Chemotherapy-related cognitive impairment and kidney dysfunction Open
Cancer and kidney diseases (KD) intersect in many ways resulting in worse outcomes. Both conditions are correlated with cognitive impairment, which can be exacerbated in cancer patients by known effects of many antineoplastic drugs on cogn…
View article: Big databases and biobanks for studying the links between CKD, cognitive impairment, and dementia
Big databases and biobanks for studying the links between CKD, cognitive impairment, and dementia Open
Research on cognitive function in individuals with chronic kidney disease (CKD) is critical due to the significant public health challenge posed by both CKD and cognitive impairment. CKD affects approximately 10–15% of the adult population…
View article: Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors
Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors Open
Chronic kidney disease is associated with cognitive impairment although the underlying mechanisms are still not fully understood. Characterization and efficient monitoring of the cognitive impact of kidney disease and ensuing therapies are…
View article: Multicentre case-control study on the association between COVID-19 vaccines and neurological disorders (COVIVAX)
Multicentre case-control study on the association between COVID-19 vaccines and neurological disorders (COVIVAX) Open
View article: Perceived ease-of-usability and local tolerability using CGRP monoclonal antibody autoinjectors <i>vs.</i> syringes: an online questionnaire-based study in patients with migraine
Perceived ease-of-usability and local tolerability using CGRP monoclonal antibody autoinjectors <i>vs.</i> syringes: an online questionnaire-based study in patients with migraine Open
Background: Monoclonal antibodies acting on the CGRP pathway (CGRP-mAbs) are characterized by subcutaneous administration via autoinjectors or prefilled syringes. Unfortunately, significant local tolerability concerns about injection site …
View article: Effect of an Internet-Based Pilates Telerehabilitation Intervention in People With Multiple Sclerosis: Protocol for a Randomized Controlled Trial
Effect of an Internet-Based Pilates Telerehabilitation Intervention in People With Multiple Sclerosis: Protocol for a Randomized Controlled Trial Open
Background Physical activity (PA) has been recommended in multiple sclerosis (MS) to maintain good physical fitness and mental health, reduce the severity of symptoms and risk of relapse, and improve quality of life. Pilates has been sugge…
View article: Harnessing Brain Plasticity: The Therapeutic Power of Repetitive Transcranial Magnetic Stimulation (rTMS) and Theta Burst Stimulation (TBS) in Neurotransmitter Modulation, Receptor Dynamics, and Neuroimaging for Neurological Innovations
Harnessing Brain Plasticity: The Therapeutic Power of Repetitive Transcranial Magnetic Stimulation (rTMS) and Theta Burst Stimulation (TBS) in Neurotransmitter Modulation, Receptor Dynamics, and Neuroimaging for Neurological Innovations Open
Transcranial magnetic stimulation (TMS) methods have become exciting techniques for altering brain activity and improving synaptic plasticity, earning recognition as valuable non-medicine treatments for a wide range of neurological disorde…
View article: Reduced neurovascular coupling of the visual network in migraine patients with aura as revealed with arterial spin labeling MRI: is there a demand-supply mismatch behind the scenes?
Reduced neurovascular coupling of the visual network in migraine patients with aura as revealed with arterial spin labeling MRI: is there a demand-supply mismatch behind the scenes? Open
View article: Cognitive impairment in CKD patients: a guidance document by the CONNECT network
Cognitive impairment in CKD patients: a guidance document by the CONNECT network Open
Cognitive impairment is a prevalent and debilitating complication in patients with chronic kidney disease (CKD). This position paper, developed by the Cognitive Decline in Nephro-Neurology: European Cooperative Target network, provides gui…
View article: Neurophysiological assessment of peripheral neuropathy through whole plantar nerve conduction in type 2 diabetes mellitus and healthy control subjects
Neurophysiological assessment of peripheral neuropathy through whole plantar nerve conduction in type 2 diabetes mellitus and healthy control subjects Open
Aim: To neurophysiologically characterize the innervation of the sole and assess the diagnostic efficacy of whole plantar nerve (WPN) conduction study in type 2 diabetes mellitus (T2DM) patients and healthy control subjects. Methods: This …
View article: Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease
Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease Open
The relationship between chronic kidney disease (CKD) and cognitive function has received increased attention in recent years. Antibacterial agents (ABs) represent a critical component of therapy regimens in patients with CKD due to increa…
View article: Altered domain-specific striatal functional connectivity in patients with Parkinson’s disease and urinary symptoms
Altered domain-specific striatal functional connectivity in patients with Parkinson’s disease and urinary symptoms Open
Background In this study, we aimed at investigating the possible association of urinary symptoms with whole-brain MRI resting-state functional connectivity (FC) alterations from distinct striatal subregions in a large cohort of early PD pa…
View article: Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey
Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey Open
Background and hypothesis There seems to be a lack of consensus on the necessity and the modality of psychological and specifically cognitive assessment of candidates for kidney transplantation. Both points are often delegated to individua…
View article: Effect of an Internet-Based Pilates Telerehabilitation Intervention in People With Multiple Sclerosis: Protocol for a Randomized Controlled Trial (Preprint)
Effect of an Internet-Based Pilates Telerehabilitation Intervention in People With Multiple Sclerosis: Protocol for a Randomized Controlled Trial (Preprint) Open
BACKGROUND Physical activity (PA) has been recommended in multiple sclerosis (MS) to maintain good physical fitness and mental health, reduce the severity of symptoms and risk of relapse, and improve quality of life. Pilates has been sugg…
View article: Screening of visuospatial abilities in amyotrophic lateral sclerosis (ALS): a pilot study using the Battery for Visuospatial Abilities (BVA)
Screening of visuospatial abilities in amyotrophic lateral sclerosis (ALS): a pilot study using the Battery for Visuospatial Abilities (BVA) Open
Background Cognitive deficits related to frontotemporal dysfunction are common in Amyotrophic Lateral Sclerosis (ALS). Visuospatial deficits, related to posterior cerebral regions, are often underestimated in ALS, though they play a crucia…
View article: A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial
A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statistical analysis plan of TUDCA-ALS trial Open
View article: Multiple Sclerosis Progression and Relapse Activity in Children
Multiple Sclerosis Progression and Relapse Activity in Children Open
Importance Although up to 20% of patients with multiple sclerosis (MS) experience onset before 18 years of age, it has been suggested that people with pediatric-onset MS (POMS) are protected against disability because of greater capacity f…
View article: COVID-19 outbreak in Italy: an opportunity to evaluate extended interval dosing of ocrelizumab in MS patients
COVID-19 outbreak in Italy: an opportunity to evaluate extended interval dosing of ocrelizumab in MS patients Open
View article: Screening of Visuospatial Abilities in Amyotrophic Lateral Sclerosis (ALS): A Pilot Study Using the Battery for Visuospatial Abilities (BVA)
Screening of Visuospatial Abilities in Amyotrophic Lateral Sclerosis (ALS): A Pilot Study Using the Battery for Visuospatial Abilities (BVA) Open
(Background) Cognitive deficits related to frontotemporal dysfunction are common in Amyotrophic Lateral Sclerosis (ALS). Visuospatial deficits, related to posterior cerebral regions, are often underestimated in ALS, though they play a cruc…
View article: Intrinsic brain functional connectivity predicts treatment-related motor complications in early Parkinson’s disease patients
Intrinsic brain functional connectivity predicts treatment-related motor complications in early Parkinson’s disease patients Open
Background Treatment-related motor complications may develop progressively over the course of Parkinson’s disease (PD). Objective We investigated intrinsic brain networks functional connectivity (FC) at baseline in a cohort of early PD pat…
View article: Repetitive Transcranial Magnetic Stimulation (rTMS) in Mild Cognitive Impairment: Effects on Cognitive Functions—A Systematic Review
Repetitive Transcranial Magnetic Stimulation (rTMS) in Mild Cognitive Impairment: Effects on Cognitive Functions—A Systematic Review Open
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique also used as a non-pharmacological intervention against cognitive impairment. The purpose of the present review was to summarize what is curr…
View article: Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor
Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor Open
People living with chronic kidney disease (CKD) frequently suffer from mild cognitive impairment and/or other neurocognitive disorders. This review in two parts will focus on adverse drug reactions resulting in cognitive impairment as a po…
View article: Drugs with a negative impact on cognitive functions (Part 2): drug classes to consider while prescribing in CKD patients
Drugs with a negative impact on cognitive functions (Part 2): drug classes to consider while prescribing in CKD patients Open
There is growing evidence that chronic kidney disease (CKD) is an independent risk factor for cognitive impairment, especially due to vascular damage, blood–brain barrier disruption and uremic toxins. Given the presence of multiple comorbi…
View article: Migraine Treatment: Towards New Pharmacological Targets
Migraine Treatment: Towards New Pharmacological Targets Open
Migraine is a debilitating neurological condition affecting millions of people worldwide. Until a few years ago, preventive migraine treatments were based on molecules with pleiotropic targets, developed for other indications, and discover…