Giorgia Tosoni
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View article: Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilience
Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilience Open
The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain controversial. While rodent studies have highlighted active roles for adult-born imm…
View article: NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer’s disease
NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer’s disease Open
The generation of new neurons at the hippocampal neurogenic niche, known as adult hippocampal neurogenesis (AHN), and its impairment, have been implicated in Alzheimer's disease (AD). MicroRNA-132 (miR-132), the most consistently downregul…
View article: Cellular and molecular mapping of human adult hippocampal neurogenesis in Alzheimer’s disease
Cellular and molecular mapping of human adult hippocampal neurogenesis in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is a progressive, irreversible disorder accounting for 50‐70% of all dementia cases. Given the current lack of disease‐modifying therapies, systematic profiling of the cell type‐ and cell state‐specific …
View article: Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease using iPSC‐derived neurons and microglia
Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease using iPSC‐derived neurons and microglia Open
Background Mapping the mechanistic heterogeneity and multifactorial nature of Alzheimer’s Disease (AD) is a key challenge for therapeutic development and the main reason why network biology and multi‐modal therapies begin to attract attent…
View article: Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease
Systematic assessment of microRNA‐132 therapeutic targeting in Alzheimer’s disease Open
Background Mapping the mechanistic heterogeneity and multifactorial nature of AD is a key challenge for therapeutic development and the main reason why network biology and multi‐modal therapies begin to attract attention also in AD researc…
View article: microRNA-132 regulates gene expression programs involved in microglial homeostasis
microRNA-132 regulates gene expression programs involved in microglial homeostasis Open
microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly downregulated microRNAs (miRNAs) in the brain of Alzheimer's disease (AD) patients. Increasing miR-132 in AD mouse brain ameliorates amyloid and Tau pathologie…
View article: Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate?
Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate? Open
View article: Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease
Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease Open
View article: microRNA-132 regulates adult neural stem cells and their progeny to restore hippocampal neurogenesis and memory in Alzheimer’s disease
microRNA-132 regulates adult neural stem cells and their progeny to restore hippocampal neurogenesis and memory in Alzheimer’s disease Open
Neural stem cells residing in the hippocampal neurogenic niche sustain life-long neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally linked to mnemonic and cognitive plasticity in humans and rodents. In Al…
View article: Bacterial peptidoglycans as novel signaling molecules from microbiota to brain
Bacterial peptidoglycans as novel signaling molecules from microbiota to brain Open
Mounting evidence indicates that gut microbiota exerts a broad range of effects on host physiology and development beyond the gastrointestinal tract, including the modulation of brain development. However, the mechanisms mediating the inte…