Giorgio Anselmi
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View article: Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity
Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ cDC1 infiltration and activates anti-tumor immunity Open
Tumor infiltration by XCR1⁺ conventional dendritic cells (cDC1) correlates strongly with favorable prognosis and improved responses to immunotherapy. Yet, tumor-driven immunosuppressive programs restrict efficient cDC1 recruitment, highlig…
View article: Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential <i>Runx1</i> +110 enhancer activity
Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential <i>Runx1</i> +110 enhancer activity Open
SUMMARY Hematopoietic stem cells (HSCs) are important in cell-based therapies for blood-related disorders. While progress has been made in the directed differentiation of pluripotent PSCs, such cultures promote hematopoietic progenitor cel…
View article: Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1 <sup>+</sup> cDC1 infiltration and activates anti-tumor immunity
Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1 <sup>+</sup> cDC1 infiltration and activates anti-tumor immunity Open
Tumor infiltration by XCR1⁺ conventional dendritic cells (cDC1) correlates strongly with favorable prognosis and improved responses to immunotherapy. Yet, tumor-driven immunosuppressive programs restrict efficient cDC1 recruitment, highlig…
View article: The Rab32 small GTPase is required for efficient cross-priming of CD8<sup>+</sup>T cells against cell-associated antigens by XCR1<sup>+</sup>type 1 DCs <i>in vivo</i>
The Rab32 small GTPase is required for efficient cross-priming of CD8<sup>+</sup>T cells against cell-associated antigens by XCR1<sup>+</sup>type 1 DCs <i>in vivo</i> Open
Type 1 conventional dendritic cells (cDC1s) are critical for initiating adaptive immune responses through the cross-priming of CD8⁺ T cells against antigens from tumor or virus-infected cells. This function depends on specialized cross-pre…
View article: Spatiotemporal dynamics of fetal liver hematopoietic niches
Spatiotemporal dynamics of fetal liver hematopoietic niches Open
Embryonic hematopoietic cells develop in the fetal liver (FL), surrounded by diverse non-hematopoietic stromal cells. However, the spatial organization and cytokine production patterns of the stroma during FL development remain poorly unde…
View article: Spatiotemporal dynamics of cytokines expression dictate fetal liver hematopoiesis
Spatiotemporal dynamics of cytokines expression dictate fetal liver hematopoiesis Open
During embryogenesis, yolk-sac and intra-embryonic-derived hematopoietic progenitors, comprising the precursors of adult hematopoietic stem cells, converge into the fetal liver. With a new staining strategy, we defined all non-hematopoieti…
View article: Dynamic<i>Runx1</i>chromatin boundaries affect gene expression in hematopoietic development
Dynamic<i>Runx1</i>chromatin boundaries affect gene expression in hematopoietic development Open
The transcription factor RUNX1 is a critical regulator of developmental hematopoiesis and is frequently disrupted in leukemia. Runx1 is a large, complex gene that is expressed from two alternative promoters under the spatiotemporal control…
View article: Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches
Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches Open
Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte develo…
View article: Engineered niches support the development of human dendritic cells in humanized mice
Engineered niches support the development of human dendritic cells in humanized mice Open
Classical dendritic cells (cDCs) are rare sentinel cells specialized in the regulation of adaptive immunity. Modeling cDC development is both crucial to study cDCs and harness their potential in immunotherapy. Here we addressed whether cDC…
View article: Cell cycle specific radiosensitisation by the disulfiram and copper complex
Cell cycle specific radiosensitisation by the disulfiram and copper complex Open
The disulfiram and copper complex (DSF:Cu) has emerged as a potent radiosensitising anti-cancer agent. The ability of copper to stabilise DSF in a planar conformation and to inhibit DNA replication enzymes stimulated our investigation of t…