Explanipedia

Electrospun Maltodextrin Fibers for Efficient Removal of Nanoparticles, Atenolol, and Crystal Violet: Preparation and Characterization Open

Eya Ben Khalifa, Claudio Cecone, Boutheina Rzig, Giorgio Mori, Federico Cesano , et al. · 2025

Maltodextrins are promising, sustainable, and low-cost materials suitable for environmental remediation applications. This study developed eco-friendly electrospun cross-linked fibers from maltodextrins (GLU2), combined with betaine, lysin…

Congenital granular cell epulis in a neonate: a case report and review of diagnosis, treatment, and prognosis Open

Placido Carlo Guidone, Roberta Seccia, Lelio Adelchi Fabrocini, Giuseppe Troiano, G Maffei , et al. · 2025

Congenital granular cell epulis (CGCE) is a rare benign tumor typically presenting at birth and most commonly located on the maxillary alveolar ridge. Case Presentation We report the case of a five-day-old female with a smooth, multilobula…

Inverse Regulation of TLR4 and PD ‐ L1 Shapes the Inflammatory Tumor Microenvironment in Oral Squamous Cell Carcinomas Open

Camila Alves Ferri, Giuseppe Pannone, Maria Carmela Pedicillo, Giorgio Mori, Ilenia Sara De Stefano , et al. · 2025

Background The interactions between malignant cells and immune cells within the tumor microenvironment (TME) significantly influence cancer development and progression. This study aimed to analyze and correlate the expression of TLR4 and P…

The Potential of Oncolytic Virotherapy in the Treatment of Head and Neck Cancer: A Comprehensive Review Open

Francesca Spirito, Riccardo Nocini, Giorgio Mori, Massimo Albanese, Eleni A. Georgakopoulou , et al. · 2024

Head and neck cancer (HNC) represents a challenging oncological entity with significant morbidity and mortality rates. Despite advances in conventional therapies, including surgery, chemotherapy, and radiation therapy, the overall survival…

TLR4 Downregulation Identifies High-Risk HPV Infection and Integration in H-SIL and Squamous Cell Carcinomas of the Uterine Cervix Open

Angela Santoro, Giuseppe Angelico, Damiano Arciuolo, Giulia Scaglione, Belen Padial Urtueta , et al. · 2024

Growing scientific evidence suggests a link between the expression of toll-like receptor 4 (TLR4) and cervical cancer carcinogenesis. Specifically, a close relation between TLR4 expression and FIGO stage, lymph node metastases, and tumor s…

Salivary exosomal microRNA profile as biomonitoring tool for diagnosis and prognosis of patients with head and neck squamous cell carcinoma: a systematic review Open

Lorenzo Sanesi, Giorgio Mori, Giuseppe Troiano, Andrea Ballini, Felice Valzano , et al. · 2024

Exosomal microRNA are promising biomarkers for HNSCC detection. MiR-10b-5p, miR-486-5p, miR-24-3p, miR-412-3p, and miR-512-3p are the most promising markers applicable to diagnostics, while miR-1307-5p and miR-519c-3p resulted overexpresse…

Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma Open

Roberta Zerlotin, Angela Oranger, Patrizia Pignataro, Manuela Dicarlo, Lorenzo Sanesi , et al. · 2024

Bone disease associated with multiple myeloma (MM) is characterized by osteolytic lesions and pathological fractures, which remain a therapeutic priority despite new drugs improving MM patient survival. Antiresorptive molecules represent t…

DOP88 Lipids drive myofibroblast activation and the epithelial-mesenchymal transition process in Crohn’s Disease Open

Giulia Rizzo, Maciej Woźny, S E Pineda Chavez, Giorgio Mori, A Carriles Linares , et al. · 2024

Background Fibrostenosis represents one of the major clinical complications of Crohn’s Disease (CD). However, the molecular mechanisms underlying intestinal fibrogenesis remain poorly understood and anti-fibrotic therapy has not yet been d…

Bioenergetic profile and redox tone modulate in vitro osteogenesis of human dental pulp stem cells: new perspectives for bone regeneration and repair Open

Francesca Agriesti, Francesca Landini, Mirko Tamma, Consiglia Pacelli, Carmela Mazzoccoli , et al. · 2023

Molecules Inducing Dental Stem Cells Differentiation and Bone Regeneration: State of the Art Open

Anastasia Ariano, Francesca Posa, Giuseppina Storlino, Giorgio Mori · 2023

Teeth include mesenchymal stem cells (MSCs), which are multipotent cells that promote tooth growth and repair. Dental tissues, specifically the dental pulp and the dental bud, constitute a relevant source of multipotent stem cells, known a…

Irisin Protects against Loss of Trabecular Bone Mass and Strength in Adult Ovariectomized Mice by Stimulating Osteoblast Activity Open

Giuseppina Storlino, Manuela Dicarlo, Roberta Zerlotin, Patrizia Pignataro, Lorenzo Sanesi , et al. · 2023

Irisin is a peptide secreted by skeletal muscle that plays a major role in bone metabolism. Experiments in mouse models have shown that administration of recombinant irisin prevents disuse-induced bone loss. In this study, we aimed to eval…

Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice Open

Manuela Dicarlo, Patrizia Pignataro, Roberta Zerlotin, Clelia Suriano, Chiara Zecca , et al. · 2023

As a result of physical exercise, muscle releases multiple exerkines, such as “irisin”, which is thought to induce pro-cognitive and antidepressant effects. We recently demonstrated in young healthy mice the mitigation of depressive behavi…

New Discoveries on Molecules Inducing Dental Stem Cells Differentiation and Bone Regeneration Open

Anastasia Ariano, Francesca Posa, Giuseppina Storlino, Giorgio Mori · 2023

Teeth include mesenchymal stem cells (MSCs), which are multipotent cells that promote tooth growth and repair. Dental tissues, specifically the dental pulp and the dental bud, constitute a relevant source of multipotent stem cells, known a…

Once-Daily Subcutaneous Irisin Administration Mitigates Depression- and Anxiety-like Behavior in Young Mice Open

Patrizia Pignataro, Manuela Dicarlo, Clelia Suriano, Lorenzo Sanesi, Roberta Zerlotin , et al. · 2023

Major depression is one of the most common psychiatric disorders worldwide, usually associated with anxiety. The multi-etiological nature of depression has increased the search for new antidepressant molecules, including irisin, for which,…

Irisin Role in Chondrocyte 3D Culture Differentiation and Its Possible Applications Open

Francesca Posa, Roberta Zerlotin, Anastasia Ariano, Michele Di Cosola, Graziana Colaianni , et al. · 2023

Irisin is a recently discovered cytokine, better known as an exercise-induced myokine, produced primarily in skeletal muscle tissue as a response to exercise. Although the skeleton was initially identified as the main target of Irisin, its…

Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing Open

Angela Oranger, Roberta Zerlotin, Cinzia Buccoliero, Lorenzo Sanesi, Giuseppina Storlino , et al. · 2023

Bone fractures are a widespread clinical event due to accidental falls and trauma or bone fragility; they also occur in association with various diseases and are common with aging. In the search for new therapeutic strategies, a crucial li…

Temporomandibular Disorders as a Risk Factor for Suicidal Behavior: A Systematic Review Open

Vittorio Dibello, Francesco Panza, Giorgio Mori, Andrea Ballini, Michele Di Cosola , et al. · 2022

Background: Temporomandibular disorders (TMD) are a group of common musculoskeletal dysfunctions that affect the temporomandibular joint or masticatory muscles and related structures or are expressed as a clinical combination of these two …

Antidepressant Effect of Intermittent Long-Term Systemic Administration of Irisin in Mice Open

Patrizia Pignataro, Manuela Dicarlo, Roberta Zerlotin, Giuseppina Storlino, Angela Oranger , et al. · 2022

Depression is a psychiatric disorder increasingly diffused worldwide. Evidence suggests that irisin, a myokine secreted by contracting muscle, mediates beneficial effects on several targets, including the brain. Here, the potential antidep…

Myoglobin expression by alternative transcript in different mesenchymal stem cells compartments Open

Rosella Scrima, Francesca Agriesti, Consiglia Pacelli, Cláudia Piccoli, Piero Pucci , et al. · 2022

Irisin and Secondary Osteoporosis in Humans Open

Roberta Zerlotin, Angela Oranger, Patrizia Pignataro, Manuela Dicarlo, Filippo Maselli , et al. · 2022

Irisin is a peptide secreted by skeletal muscle following exercise that plays an important role in bone metabolism. Numerous experiments in vitro and in mouse models have shown that the administration of recombinant irisin promotes osteoge…

Retrospective Analysis of Clinical and Radiologic Data Regarding Zygomatic Implant Rehabilitation with a Long-Term Follow-Up Open

Michele Di Cosola, Andrea Ballini, Khrystyna Zhurakivska, Alberto Ceccarello, Riccardo Nocini , et al. · 2021

Background: Zygomatic implants have been introduced to rehabilitate edentulous patients with severely atrophic maxillae. Their use has been reported by several studies, describing high overall survival rates at medium–long follow-up. The a…

The Myokine Irisin Promotes Osteogenic Differentiation of Dental Bud-Derived MSCs Open

Francesca Posa, Graziana Colaianni, Michele Di Cosola, Manuela Dicarlo, Francesco Gaccione , et al. · 2021

The myokine irisin, well known for its anabolic effect on bone tissue, has been demonstrated to positively act on osteoblastic differentiation processes in vitro. Mesenchymal stem cells (MSCs) have captured great attention in precision med…

Surface Co-presentation of BMP-2 and integrin selective ligands at the nanoscale favors α5β1 integrin-mediated adhesion Open

Francesca Posa, Elisabeth Baha-Schwab, Qiang Wei, Adriana Di Benedetto, Stefanie Neubauer , et al. · 2020

Here we present the use of surface nanopatterning of covalently immobilized BMP-2 and integrin selective ligands to determine the specificity of their interactions in regulating cell adhesion and focal adhesion assembly. Gold nanoparticle …

Editorial: Special Issue on “Molecular Mechanisms Regulating Osteoclastogenesis” Open

Giacomina Brunetti, Giorgio Mori, Maria Felicia Faienza · 2020

Bone is an active tissue that remodels continuously throughout life [...]

Bioengineering Bone Tissue with 3D Printed Scaffolds in the Presence of Oligostilbenes Open

Francesca Posa, Adriana Di Benedetto, Giampietro Ravagnan, Elisabetta Ada Cavalcanti‐Adam, Lorenzo Lo Muzio , et al. · 2020

Diseases determining bone tissue loss have a high impact on people of any age. Bone healing can be improved using a therapeutic approach based on tissue engineering. Scientific research is demonstrating that among bone regeneration techniq…

Irisin treatment prevents dysregulation of osteoblast differentiation and activity in 3D in vitro bone cocultures exposed to microgravity during the space flight CRS-14 mission Open

Graziana Colaianni, Silvia Colucci, Giacomina Brunetti, Giorgio Mori, Maria Grano · 2020

Editorial: Advances in Endocrinology: Stem Cells and Growth Factors Open

Andrea Ballini, Salvatore Scacco, Rajiv Saini, Stefania Cantore, Giorgio Mori · 2020

Stem Cells investigation in Endocrinology: leading stem cell scientists and developmental endocrinologists, critically review both cutting-edge approaches to stem cell biology and the application of stem cells and their secretome to transl…

Irisin prevents microgravity‐induced impairment of osteoblast differentiation in vitro during the space flight CRS‐14 mission Open

Silvia Colucci, Graziana Colaianni, Giacomina Brunetti, Francesca Ferranti, Gabriele Mascetti , et al. · 2020

Understanding molecular mechanisms responsible for bone cells unbalance in microgravity would allow the development of better countermeasures for astronauts, and eventually advancing terrestrial osteoporosis treatments. We conduct a unique…

Osteogenic and Chondrogenic Potential of the Supramolecular Aggregate T-LysYal® Open

Adriana Di Benedetto, Francesca Posa, Mario Marazzi, Zamira Kalemaj, Roberta Grassi , et al. · 2020

Hard tissue regeneration represents a challenge for the Regenerative Medicine and Mesenchymal stem cells (MSCs) could be a successful therapeutic strategy. T-LysYal® (T-Lys), a new derivative of Hyaluronic Acid (HA) possessing a superior s…

Editorial: Updates on Osteoimmunology: What's New on the Crosstalk Between Bone and Immune Cells Open

Giacomina Brunetti, Patrizia D’Amelio, Giorgio Mori, Maria Felicia Faienza · 2020

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