Giovambattista Desideri
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View article: Neutrophil cathepsin G and risk of cardiovascular events in patients with diabetes mellitus
Neutrophil cathepsin G and risk of cardiovascular events in patients with diabetes mellitus Open
NCT01882114, NCT04036357.
View article: Frailty elements, direct oral anticoagulants and mortality risk in atrial fibrillation patients aged ≥ 80 or ≥ 90 years from the nationwide Italian START registry: a propensity score matching analysis
Frailty elements, direct oral anticoagulants and mortality risk in atrial fibrillation patients aged ≥ 80 or ≥ 90 years from the nationwide Italian START registry: a propensity score matching analysis Open
This study aims to investigate the use of direct oral anticoagulants (DOACs) in elderly frail patients with atrial fibrillation (AF). In 4244 patients aged ≥ 80 years and 533 aged ≥ 90 years from the nationwide START registry, we examined …
View article: Environmental and social determinants of cardiovascular risk in women with type 2 diabetes: a life-course perspective
Environmental and social determinants of cardiovascular risk in women with type 2 diabetes: a life-course perspective Open
Background Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality among women with type 2 diabetes (T2DM). The interplay between sex-specific biological factors, social determinants, and environmental exposures a…
View article: Metabolic Determinants of Systemic Inflammation Dynamics During Hemodialysis: Insights from the Systemic Immune–Inflammation Index in a Single-Center Observational Study
Metabolic Determinants of Systemic Inflammation Dynamics During Hemodialysis: Insights from the Systemic Immune–Inflammation Index in a Single-Center Observational Study Open
Background/Objective: Systemic inflammation is a hallmark of end-stage renal disease (ESRD) and contributes to the high burden of cardiovascular morbidity and mortality in hemodialysis (HD) patients. The systemic immune–inflammation index …
View article: The I-KAPCAM-AI-Q: a novel instrument for evaluating health care providers’ AI awareness in Italy
The I-KAPCAM-AI-Q: a novel instrument for evaluating health care providers’ AI awareness in Italy Open
Background Understanding healthcare providers’ readiness and attitudes is crucial for integrating AI in healthcare, yet no validated tool exists to evaluate these aspects among Italian physicians. This study developed and validated the Ita…
View article: Metabolic Dysfunction-Associated Steatotic Liver Disease: A Silent Driver of Cardiovascular Risk and a New Target for Intervention
Metabolic Dysfunction-Associated Steatotic Liver Disease: A Silent Driver of Cardiovascular Risk and a New Target for Intervention Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) significantly increases the risk of steatohepatitis and cirrhosis and multiple extrahepatic complications, in particular, cardiometabolic disease, including type 2 diabetes, …
View article: Comparative Study Between the Short-Term Effects of Replacement Therapy with Liquid and Tablet Formulations of Levothyroxine on Insulin Resistance Markers in Recently Thyroidectomized Female Patients
Comparative Study Between the Short-Term Effects of Replacement Therapy with Liquid and Tablet Formulations of Levothyroxine on Insulin Resistance Markers in Recently Thyroidectomized Female Patients Open
Background/Objectives: Levothyroxine (L-T4) replacement therapy is essential following total thyroidectomy. While liquid L-T4 formulations exhibit superior pharmacokinetic properties compared to tablets, their specific metabolic impact—par…
View article: Medical Clinical Minds Meet Artificial Intelligence: Italian Physicians’ Knowledge, Attitudes, and Concordance between Italian Physicians and AI-Generated Diagnoses. A National Cross-Sectional Study
Medical Clinical Minds Meet Artificial Intelligence: Italian Physicians’ Knowledge, Attitudes, and Concordance between Italian Physicians and AI-Generated Diagnoses. A National Cross-Sectional Study Open
Background Artificial Intelligence has increasingly been integrated into clinical practice, yet its adoption and perception among medical professionals remain poorly understood, particularly in the Italian healthcare system. To investigate…
View article: Triglyceride-glucose index threshold for cardiovascular mortality in hypertensive individuals - URRAH project
Triglyceride-glucose index threshold for cardiovascular mortality in hypertensive individuals - URRAH project Open
View article: Correction: The PREVASC study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts
Correction: The PREVASC study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts Open
PREVASC study
View article: Patient perceptions, motivations and barriers to treatment adherence in hypertension: results of a questionnaire-based survey in five European countries
Patient perceptions, motivations and barriers to treatment adherence in hypertension: results of a questionnaire-based survey in five European countries Open
This large survey reveals several underestimated issues regarding patients' perspective in hypertension. It highlights the impact of emotions, exposure to family hardships, and stress on the risk of non-adherence. Non-adherence is underrep…
View article: Reconciling Complex Historical Records with Omeka S Relational Database The Case of the Graziani Archive
Reconciling Complex Historical Records with Omeka S Relational Database The Case of the Graziani Archive Open
The paper focuses on extracting data from correspondence related to diplomatic missions by Giovanni Francesco Commendone and Antonio Maria Graziani in sixteenth‑century Poland. This data is integrated into Omeka S, an open‑source platform …
View article: Arrhythmic burden of long-term postsurgical hypoparathyroidism assessed with 24-hour Holter ECG
Arrhythmic burden of long-term postsurgical hypoparathyroidism assessed with 24-hour Holter ECG Open
Purpose Postsurgical hypoparathyroidism is associated with an increased cardiovascular risk, however an increased arrhythmic risk in this population is controversial. Methods Twenty-two postmenopausal women with postsurgical hypoparathyroi…
View article: Lipid-Lowering Therapy and Cardiovascular Prevention in Elderly
Lipid-Lowering Therapy and Cardiovascular Prevention in Elderly Open
View article: The I-KAPCAM-AI-Q: A Novel Instrument for Evaluating Health Care Providers’ AI Awareness in Italy
The I-KAPCAM-AI-Q: A Novel Instrument for Evaluating Health Care Providers’ AI Awareness in Italy Open
Background: Understanding healthcare providers’ readiness and attitudes is crucial for integrating AI in healthcare, yet no validated tool exists to evaluate these aspects among Italian physicians. This study developed and validated the It…
View article: The PREVASC study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts
The PREVASC study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts Open
Aims Valvular heart disease (VHD) is the third leading cause of cardiovascular morbidity, with its incidence and public health impact projected to increase significantly. This study adopts a novel perspective, focusing on elderly individua…
View article: Impact of Hospitalization on Sarcopenia, NADPH-Oxidase 2, Oxidative Stress, and Low-Grade Endotoxemia in Elderly Patients
Impact of Hospitalization on Sarcopenia, NADPH-Oxidase 2, Oxidative Stress, and Low-Grade Endotoxemia in Elderly Patients Open
Background: Hospitalization in older adults often worsens sarcopenia due to prolonged bed rest, poor nutrition, and inactivity. This study examined how hospitalization impacts muscle mass, focusing on oxidative stress and gut-derived endot…
View article: A rare case of right-sided chylothorax induced by vertebral osteophytosis in a nonagenarian patient
A rare case of right-sided chylothorax induced by vertebral osteophytosis in a nonagenarian patient Open
Background: Chylothorax is an abnormal accumulation of lymphatic fluid in the pleural cavity, and it develops because of chyle leaking from the thoracic duct. The clinical presentation can be varied, while symptoms depend on its size and t…
View article: “Minimal-Advice” on Salt Intake: Results of a Multicentre Pilot Randomised Controlled Trial on Hypertensive Patients
“Minimal-Advice” on Salt Intake: Results of a Multicentre Pilot Randomised Controlled Trial on Hypertensive Patients Open
ClinicalTrial.gov registration number: NCT06651437.
View article: Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study
Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study Open
Both IR and SUA/GFR ratio independently predict CV mortality, regardless of age, gender, BMI, diabetes, hypertension and statin use. The joint effect of the TG/HDL-C ratio and the elevated SUA/GFR ratio was greater than the presence of eac…
View article: Predictive Value of Insulin Resistance and GFR-Adjusted Uric Acid Levels on Cardiovascular Mortality: The Urrah Study
Predictive Value of Insulin Resistance and GFR-Adjusted Uric Acid Levels on Cardiovascular Mortality: The Urrah Study Open
Background Insulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway and contributing to IR, while IR is a known predictor for the development of hyperu…
View article: Influence of Uric Acid on Vascular and Cognitive Functions: Evidence for an Ambivalent Relationship
Influence of Uric Acid on Vascular and Cognitive Functions: Evidence for an Ambivalent Relationship Open
The growing recognition of the public health impact of cognitive impairment and dementia has sparked a global initiative to identify risk factors and develop strategies to prevent or slow the progression of these cognitive disorders. Uric …
View article: The PREVASC Study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts
The PREVASC Study: Prospective REgistry of Valve disease in Asymptomatic Italian elderly SubjeCts Open
Aims Valvular heart disease (VHD) is the third most common cause of cardiovascular morbidity, and its incidence and impact on public health is expected to rise substantially. This study explores an unconventional perspective, focusing on e…
View article: Increased nocturnal urinary cortisol levels in the elderly patients with depression, coexisting major geriatric syndromes and combined pathogenetic mechanisms
Increased nocturnal urinary cortisol levels in the elderly patients with depression, coexisting major geriatric syndromes and combined pathogenetic mechanisms Open
View article: Rate and predictors of thromboprophylaxis in internal medicine wards: Results from the AURELIO study
Rate and predictors of thromboprophylaxis in internal medicine wards: Results from the AURELIO study Open
View article: Update on Obesity and Cardiovascular Risk: From Pathophysiology to Clinical Management
Update on Obesity and Cardiovascular Risk: From Pathophysiology to Clinical Management Open
Obesity is an epidemic worldwide. Overweight and multiple obesity-related mechanisms, including dysmetabolic alterations, contribute to cardiovascular deleterious effects. Hence, overweight and obesity have been independently associated wi…
View article: Efficacy and Safety of Low-Dose Bisoprolol/Hydrochlorothiazide Combination for the Treatment of Hypertension: A Systematic Review and Meta-Analysis
Efficacy and Safety of Low-Dose Bisoprolol/Hydrochlorothiazide Combination for the Treatment of Hypertension: A Systematic Review and Meta-Analysis Open
Objectives: This systematic review and meta-analysis aimed to assess the blood pressure (BP)-lowering effect and the safety profile of low-dose bisoprolol/hydrochlorothiazide combination treatment in patients with hypertension. Methods: Mu…
View article: Impact of Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i) Therapy on Dementia and Cognitive Decline
Impact of Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i) Therapy on Dementia and Cognitive Decline Open
Dementia is an age-related syndrome characterized by the progressive deterioration of cognition and capacity for independent living. Diabetes is often associated with cognitive decline and shares similar pathophysiological mechanisms with …
View article: Risk of Cardiovascular Events in Metabolically Healthy Overweight or Obese Adults: Role of LDL-Cholesterol in the Stratification of Risk
Risk of Cardiovascular Events in Metabolically Healthy Overweight or Obese Adults: Role of LDL-Cholesterol in the Stratification of Risk Open
The objective of this study was to investigate the longitudinal association of metabolically healthy overweight/obese adults with major adverse cardiovascular events (MACE) and the effect of LDL-cholesterol levels on this association. This…
View article: Serum Uric Acid, Hypertriglyceridemia, and Carotid Plaques: A Sub-Analysis of the URic Acid Right for Heart Health (URRAH) Study
Serum Uric Acid, Hypertriglyceridemia, and Carotid Plaques: A Sub-Analysis of the URic Acid Right for Heart Health (URRAH) Study Open
High levels of serum uric acid (SUA) and triglycerides (TG) might promote high-cardiovascular-risk phenotypes, including subclinical atherosclerosis. An interaction between plaques xanthine oxidase (XO) expression, SUA, and HDL-C has been …