Giovanni Damiani
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View article: Towards the development of upgrade criteria for the treatment of hidradenitis suppurativa with biologics
Towards the development of upgrade criteria for the treatment of hidradenitis suppurativa with biologics Open
Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized primarily by dysregulated innate immunity and abnormal keratinocyte differentiation. Over the past two decades, the treatment paradigm has evolve…
View article: Advances in Cell-Mediated Drug Delivery for Dermatologic Diseases: Mechanisms and Current Applications
Advances in Cell-Mediated Drug Delivery for Dermatologic Diseases: Mechanisms and Current Applications Open
Cell-mediated drug delivery systems represent a promising frontier in dermatologic therapy by offering enhanced targeting precision, prolonged drug release, and reduced systemic toxicity. These systems leverage the intrinsic properties of …
View article: A 14-year multicentric follow-up study of atypical pemphigus variants in Italy: the VARIANT_P study
A 14-year multicentric follow-up study of atypical pemphigus variants in Italy: the VARIANT_P study Open
Background The clinical, epidemiological and immunopathological profiles of atypical forms of pemphigus remain only partially known. Objectives To define the clinical, epidemiological and immunological characteristics, therapies and outcom…
View article: Evaluation of Combined Treatment With Picosecond Laser and Acoustic Shock Wave Therapy for Tattoo Removal: A Prospective Randomized Controlled Trial
Evaluation of Combined Treatment With Picosecond Laser and Acoustic Shock Wave Therapy for Tattoo Removal: A Prospective Randomized Controlled Trial Open
Background Laser tattoo removal traditionally employs q‐switched and picosecond lasers, which require multiple sessions. Besides the selective photothermolysis that laser devices offer, the photoacoustic effect by acoustic pulse devices ma…
View article: How to Establish the Baseline for Non-Invasive Technological Regenerative Esthetic Medicine in the Face and Neck Region: A Literature Review
How to Establish the Baseline for Non-Invasive Technological Regenerative Esthetic Medicine in the Face and Neck Region: A Literature Review Open
(1) Background: Esthetic regenerative medicine is increasingly in demand for facial and neck rejuvenation due to its proven efficacy, safety profile, and minimal downtime. This study aimed to evaluate the role of standardized assessment to…
View article: Structural Insights: What Makes Some PDE4 Inhibitors More Effective in Inflammatory Dermatoses.
Structural Insights: What Makes Some PDE4 Inhibitors More Effective in Inflammatory Dermatoses. Open
Psoriasis, seborrheic dermatitis, and atopic dermatitis are chronic inflammatory skin diseases affecting millions of people in the United States and worldwide across the human lifespan. The immune pathways underlying the pathogenesis of th…
View article: Fluoroquinolones for Dermatologists: A Practical Guide to Clinical Use and Risk Management
Fluoroquinolones for Dermatologists: A Practical Guide to Clinical Use and Risk Management Open
Background: Fluoroquinolones, available in topical and oral formulations, are used to manage bacterial skin and soft tissue infections, including Pseudomonas aeruginosa, atypical mycobacteria, and select multidrug-resistant Gram-negative o…
View article: Understanding the atopic dermatitis-psoriasis phenotypic switch through a mechanistic epidemiology approach
Understanding the atopic dermatitis-psoriasis phenotypic switch through a mechanistic epidemiology approach Open
Atopic Dermatitis (AD) and psoriasis (PsO) are two frequent dermatologic conditions that may co-occur in a cluster of patients, yet current understanding of how these two conditions relate to one-another remains poorly understood. One way …
View article: State of health and inequalities among Italian regions from 2000 to 2021: a systematic analysis based on the Global Burden of Disease Study 2021
State of health and inequalities among Italian regions from 2000 to 2021: a systematic analysis based on the Global Burden of Disease Study 2021 Open
View article: Impaired Molecular Mechanisms Contributing to Chronic Pain in Patients with Hidradenitis Suppurativa: Exploring Potential Biomarkers and Therapeutic Targets
Impaired Molecular Mechanisms Contributing to Chronic Pain in Patients with Hidradenitis Suppurativa: Exploring Potential Biomarkers and Therapeutic Targets Open
Hidradenitis suppurativa (HS) is a chronic skin condition that primarily affects areas with dense hair follicles and apocrine sweat glands, such as the underarms, groin, buttocks, and lower breasts. Intense pain and discomfort in HS have b…
View article: Management of Systemic Anti-psoriatic Drugs in Psoriasis Patients with Concurrent Paraplegia or Tetraplegia: Insights From a 6-Year Multicenter, Retrospective Observational Study
Management of Systemic Anti-psoriatic Drugs in Psoriasis Patients with Concurrent Paraplegia or Tetraplegia: Insights From a 6-Year Multicenter, Retrospective Observational Study Open
View article: How Should We Use Hyaluronidase for Dissolving Hyaluronic Acid Fillers?
How Should We Use Hyaluronidase for Dissolving Hyaluronic Acid Fillers? Open
Background Hyaluronic acid (HA) fillers are commonly used in esthetic medicine for facial contouring and rejuvenation. However, complications such as overcorrection, vascular occlusion, and irregular filler distribution necessitate the use…
View article: DNA methylation patterns of circadian and ultradian genes are altered in the peripheral blood of patients with hidradenitis suppurativa
DNA methylation patterns of circadian and ultradian genes are altered in the peripheral blood of patients with hidradenitis suppurativa Open
Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that affects hair follicles in areas with apocrine sweat glands, such as the underarms, groin, and buttocks. The pathogenesis of HS is not fully understood, …
View article: Exploring the relationship between morphea and malignancy: a decade-long single-center study of 204 patients
Exploring the relationship between morphea and malignancy: a decade-long single-center study of 204 patients Open
View article: Exploring the Relationship Between Morphea and Malignancy: A Decade-Long Single- Center Study of 204 Patients
Exploring the Relationship Between Morphea and Malignancy: A Decade-Long Single- Center Study of 204 Patients Open
The association between systemic scleroderma and malignancy is well-documented, but there is limited data on the relationship between morphea and malignancy. This study aims to assess the incidence and types of malignancies in morphea pati…
View article: Heterogeneous IL-9 Production by Circulating Skin-Tropic and Extracutaneous Memory T Cells in Atopic Dermatitis Patients
Heterogeneous IL-9 Production by Circulating Skin-Tropic and Extracutaneous Memory T Cells in Atopic Dermatitis Patients Open
Interleukin (IL)-9 is present in atopic dermatitis (AD) lesions and is considered to be mainly produced by skin-homing T cells expressing the cutaneous lymphocyte-associated antigen (CLA). However, its induction by AD-associated triggers r…
View article: The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019
The state of health in the European Union (EU-27) in 2019: a systematic analysis for the Global Burden of Disease study 2019 Open
View article: Deregulated Long Non-Coding RNAs (lncRNA) as Promising Biomarkers in Hidradenitis Suppurativa
Deregulated Long Non-Coding RNAs (lncRNA) as Promising Biomarkers in Hidradenitis Suppurativa Open
Background/Objectives: In recent times, epigenetics alterations in Hidradenitis suppurativa (HS) have been explored and exploited translationally to guide investigation of new therapeutic approaches. On the other hand, long noncoding RNAs …
View article: Corrigendum: Time-Trends in Air Pollution Impact on Health in Italy, 1990–2019: An Analysis from the Global Burden of Disease Study 2019
Corrigendum: Time-Trends in Air Pollution Impact on Health in Italy, 1990–2019: An Analysis from the Global Burden of Disease Study 2019 Open
[This corrects the article DOI: 10.3389/ijph.2023.1605959.].
View article: Telemedicine in Nail Psoriasis: Validation of a New Tool to Monitor (In-Person, In-Picture, and In-Video) Nail Psoriasis Severity in Patients with Concurrent Onychophagia and Onychotillomania
Telemedicine in Nail Psoriasis: Validation of a New Tool to Monitor (In-Person, In-Picture, and In-Video) Nail Psoriasis Severity in Patients with Concurrent Onychophagia and Onychotillomania Open
View article: Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution
Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution Open
Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory dermatological condition characterized by painful and recurrent nodules and purulent abscesses. HS can have a devastating impact on the quality of life of patients. …
View article: BJD Reviewers January 2023–December 2023
BJD Reviewers January 2023–December 2023 Open
View article: Responses of Freshwater Invertebrates to Imhoff Tank Sewage Effluents: A Preliminary Study in Four Watercourses with Different Ecological Status (Abruzzo, Central Italy)
Responses of Freshwater Invertebrates to Imhoff Tank Sewage Effluents: A Preliminary Study in Four Watercourses with Different Ecological Status (Abruzzo, Central Italy) Open
In many EU countries, a large proportion of domestic effluents is treated in small, decentralized wastewater treatment plants (WWTPs) which often lack appropriate treatment technologies. The low efficiency of these systems and their incorr…
View article: Dermatoscopic patterns of cutaneous metastases: A multicentre cross‐sectional study of the International Dermoscopy Society
Dermatoscopic patterns of cutaneous metastases: A multicentre cross‐sectional study of the International Dermoscopy Society Open
Background The detection of cutaneous metastases (CMs) from various primary tumours represents a diagnostic challenge. Objectives Our aim was to evaluate the general characteristics and dermatoscopic features of CMs from different primary …
View article: Structural Basis for p19 Targeting by Anti–IL-23 Biologics: Correlations with Short- and Long-Term Efficacy in Psoriasis
Structural Basis for p19 Targeting by Anti–IL-23 Biologics: Correlations with Short- and Long-Term Efficacy in Psoriasis Open
IL-23 is central to psoriasis pathogenesis. Biologics targeting IL-23 are important therapies against psoriasis. IL-23 inhibitors risankizumab, tildrakizumab, and guselkumab bind the IL-23 p19 subunit, whereas ustekinumab binds p40; howeve…
View article: Dataset related to article "Brodalumab for the treatment of plaque psoriasis in a real-life setting: a 3 years multicenter retrospective study-IL PSO (Italian landscape psoriasis) "
Dataset related to article "Brodalumab for the treatment of plaque psoriasis in a real-life setting: a 3 years multicenter retrospective study-IL PSO (Italian landscape psoriasis) " Open
<p><strong>Abstract</strong></p>\n<div>\n<p><strong> Introduction: </strong> Brodalumab is a monoclonal antibody that targets the subunit A of the interleukin-17A receptor (IL17RA), inhibitin…
View article: Effectiveness, Tolerability, and Drug Survival of Risankizumab in a Real-World Setting: A Three-Year Retrospective Multicenter Study—IL PSO (ITALIAN LANDSCAPE PSORIASIS)
Effectiveness, Tolerability, and Drug Survival of Risankizumab in a Real-World Setting: A Three-Year Retrospective Multicenter Study—IL PSO (ITALIAN LANDSCAPE PSORIASIS) Open
Background: Risankizumab is a humanized monoclonal antibody that selectively inhibits interleukin-23. It has been approved for moderate-to-severe plaque psoriasis and has shown efficacy and safety in clinical trials and real-world experien…
View article: Drug survival of IL-12/23, IL-17 and IL-23 inhibitors for moderate-to-severe plaque psoriasis: a retrospective multicenter real-world experience on 5932 treatment courses – IL PSO (Italian landscape psoriasis)
Drug survival of IL-12/23, IL-17 and IL-23 inhibitors for moderate-to-severe plaque psoriasis: a retrospective multicenter real-world experience on 5932 treatment courses – IL PSO (Italian landscape psoriasis) Open
Introduction The development of several effective biological drugs for moderate-to-severe plaque psoriasis has dramatically changed the lives of patients. Despite the wide use of interleukin (IL) inhibitors, limited data are available to d…
View article: Multi‐failure psoriasis patients: characterization of the patients and response to biological therapy in a multicenter Italian cohort
Multi‐failure psoriasis patients: characterization of the patients and response to biological therapy in a multicenter Italian cohort Open
Introduction Patients with psoriasis who have failed multiple biologic drugs have been defined as “multi‐failure,” although there are no clear data on the characteristics, comorbidities, and best treatment strategies for this population. N…
View article: Epidemiology, Characteristics of Disease, and Unmet Needs of Patients with Generalized Pustular Psoriasis: A Large Italian Delphi Consensus
Epidemiology, Characteristics of Disease, and Unmet Needs of Patients with Generalized Pustular Psoriasis: A Large Italian Delphi Consensus Open
Introduction: Generalized pustular psoriasis (GPP) is a rare and chronic, debilitating skin condition characterized, in its acute flare phase, by clinically severe and potentially life-threatening systemic manifestations. Dat…