Giovanni Gaudino YOU? Author Swipe

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Germline <i>BARD1</i> variants predispose to mesothelioma by impairing DNA repair and calcium signaling Open

Flavia Novelli, Yoshie Yoshikawa, Veronica Angela Maria Vitto, Lorenzo Modesti, Michael Minaai , et al. · 2024

We report that ~1.8% of all mesothelioma patients and 4.9% of those younger than 55, carry rare germline variants of the BRCA1 associated RING domain 1 ( BARD1) gene that were predicted to be damaging by computational analyses. We conducte…

HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma Open

Joelle Sacks Suarez, Flavia Novelli, Keisuke Goto, Michiko Ehara, Mika Steele , et al. · 2023

Asbestos is the main cause of malignant mesothelioma. Previous studies have linked asbestos-induced mesothelioma to the release of HMGB1 from the nucleus to the cytoplasm, and from the cytoplasm to the extracellular space. In the cytoplasm…

Supplementary Figure 6 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 2458K, CSPG4 knockdown decreases the rate of wound healing in MM cells.

Supplementary Figure Legend from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 91K.

Supplementary Figure 6 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 2458K, CSPG4 knockdown decreases the rate of wound healing in MM cells.

Supplementary Figure 5 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 3582K, CSPG4-specific mAb TP41.2 reduces MM wound healing.

Supplementary Figure 3 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 4250K, The interaction between CSPG4 and the extracellular matrix (ECM) promotes MM cell adhesion.

Supplementary Figure 3 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 4250K, The interaction between CSPG4 and the extracellular matrix (ECM) promotes MM cell adhesion.

Data from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

Purpose: Malignant mesothelioma (MM) is an aggressive cancer, resistant to current therapies. Membrane chondroitin sulphate proteoglycan 4 (CSPG4), which has been successfully targeted in melanoma and breast cancer, was found highly…

Supplementary Figure Legend from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 91K.

Supplementary Figure 4 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 2167K, CSPG4 knockdown reduces MM cell migration.

Supplementary Figure 4 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 2167K, CSPG4 knockdown reduces MM cell migration.

Supplementary Figure 2 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 2191K, Silencing of CSPG4 expression in MM cells.

Supplementary Figure 1 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 1296K, Characterization of CSPG4 in Malignant Mesothelioma.

Supplementary Figure 1 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 1296K, Characterization of CSPG4 in Malignant Mesothelioma.

Data from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

Purpose: Malignant mesothelioma (MM) is an aggressive cancer, resistant to current therapies. Membrane chondroitin sulphate proteoglycan 4 (CSPG4), which has been successfully targeted in melanoma and breast cancer, was found highly…

Supplementary Figure 5 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 3582K, CSPG4-specific mAb TP41.2 reduces MM wound healing.

Supplementary Figure 2 from CSPG4 as a Target of Antibody-Based Immunotherapy for Malignant Mesothelioma Open

Zeyana Rivera, Soldano Ferrone, Xinhui Wang, Sandro Jube, Haining Yang , et al. · 2023

PDF file, 2191K, Silencing of CSPG4 expression in MM cells.

Supplementary Materials and Methods from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open

Sandro Jube, Zeyana S. Rivera, Marco E. Bianchi, Amy Powers, Ena Wang , et al. · 2023

PDF file - 106K

Supplementary Materials and Methods from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open

Sandro Jube, Zeyana S. Rivera, Marco E. Bianchi, Amy Powers, Ena Wang , et al. · 2023

PDF file - 106K

Data from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open

Sandro Jube, Zeyana S. Rivera, Marco E. Bianchi, Amy Powers, Ena Wang , et al. · 2023

Human malignant mesothelioma is an aggressive and highly lethal cancer that is believed to be caused by chronic exposure to asbestos and erionite. Prognosis for this cancer is generally poor because of late-stage diagnosis and resistance t…

Data from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open

Sandro Jube, Zeyana S. Rivera, Marco E. Bianchi, Amy Powers, Ena Wang , et al. · 2023

Human malignant mesothelioma is an aggressive and highly lethal cancer that is believed to be caused by chronic exposure to asbestos and erionite. Prognosis for this cancer is generally poor because of late-stage diagnosis and resistance t…

Supplementary Figures 1-10 from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open

Sandro Jube, Zeyana S. Rivera, Marco E. Bianchi, Amy Powers, Ena Wang , et al. · 2023

PDF file - 4.5MB, Figure S1. HMGB1 inhibitors hinder asbestos-induced HM transformation. Figure S2. Expressions of the HMGB1 receptors TLR2 and TLR4 are variable in MM cells. Figure S3. HMGB1 is a chemotactic and mitogenic factor in MM cel…

Supplementary Figures 1-10 from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma Open

Sandro Jube, Zeyana S. Rivera, Marco E. Bianchi, Amy Powers, Ena Wang , et al. · 2023

PDF file - 4.5MB, Figure S1. HMGB1 inhibitors hinder asbestos-induced HM transformation. Figure S2. Expressions of the HMGB1 receptors TLR2 and TLR4 are variable in MM cells. Figure S3. HMGB1 is a chemotactic and mitogenic factor in MM cel…

BAP1 is a novel regulator of HIF-1α Open

Angela Bononi, Qian Wang, Alicia A. Zolondick, Fang Bai, Mika Steele-Tanji , et al. · 2023

BAP1 is a powerful tumor suppressor gene characterized by haplo insufficiency. Individuals carrying germline BAP1 mutations often develop mesothelioma, an aggressive malignancy of the serosal layers covering the lungs, pericardium, and abd…

Standard model anomalies: Lepton flavour non-universality and lepton $g-2$ Open

Alessandra D'Alise, L. Lista, Maria Grazia Di Luca, Giuseppe Fabiano, Domenico Frattulillo , et al. · 2022

We critically analyze the body of results that hints to the existence of New Physics from possible violations of lepton universality observed by the LHCb experiment in the μ/e ratios R$_{K}$ and $ {R}_{K^{\\ast }} $ to the g − 2 lepton ano…

BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos Open

Flavia Novelli, Angela Bononi, Qian Wang, Fang Bai, Simone Patergnani , et al. · 2021

Significance Our findings explain mechanistically the observed gene × environment (G×E) interaction in mesotheliomas occurring in carriers of heterozygous germline BAP1 mutations ( BAP1 +/− ) exposed to asbestos. The increased amount of ac…

Asbestos-induced chronic inflammation in malignant pleural mesothelioma and related therapeutic approaches—a narrative review Open

Alicia A. Zolondick, Giovanni Gaudino, Jiaming Xue, Harvey I. Pass, Michele Carbone , et al. · 2021

Key regulators of chronic inflammation mediate asbestos-driven mesothelial cell transformation and survival through autophagic pathways. Recent studies have elucidated some of the key mechanisms involved in asbestos-induced chronic inflamm…

Heterozygous germline <i>BLM</i> mutations increase susceptibility to asbestos and mesothelioma Open

Angela Bononi, Keisuke Goto, Güntülü Ak, Yoshie Yoshikawa, Mitsuru Emi , et al. · 2020

Significance We found that the probability of carrying heterozygous germline BLM mutations is significantly higher among mesothelioma patients than in the general population. In vitro and in vivo experiments suggest that heterozygous BLM m…

HMGB1 as a therapeutic target in disease Open

Jiaming Xue, Joelle Sacks Suarez, Michael Minaai, Shuangjing Li, Giovanni Gaudino , et al. · 2020

High‐mobility group box 1 (HMGB1) was initially recognized as a ubiquitous nuclear protein involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 has since been reevaluated to be a prototypical damage‐a…

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