Giovanni Giangreco
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View article: Cooperative and antagonistic interactions between sub-clones favour the co-existence of multiple resistance mechanisms in melanoma
Cooperative and antagonistic interactions between sub-clones favour the co-existence of multiple resistance mechanisms in melanoma Open
Resistance to targeted therapies develops in the majority of patients, with numerous different mechanisms having been documented. This is frequently linked to intra-tumour heterogeneity and cancer cells transitioning into different states.…
View article: Multicellular Calcium Waves in Cancer-Associated Fibroblasts Regulate Neuronal Mimicry and Anisotropy Leading to Immune Exclusion
Multicellular Calcium Waves in Cancer-Associated Fibroblasts Regulate Neuronal Mimicry and Anisotropy Leading to Immune Exclusion Open
Summary Stromal barriers exclude CD8+ T cells from accessing cancer cells and hamper immune-mediated tumour control. Through multi-pronged analysis of tumours that transition from immune inflamed to immune excluded, we reveal that the form…
View article: Rapid expansion of podoplanin-positive fibroblasts following radiation limits the anti-tumour CD8+ T-cell response to radiotherapy
Rapid expansion of podoplanin-positive fibroblasts following radiation limits the anti-tumour CD8+ T-cell response to radiotherapy Open
Radiotherapy is known to cause changes in the tumour stroma which can undermine treatment efficacy. Our understanding of this process has historically centred around effects driven by Transforming Growth Factor-beta (TGF-β) and alpha-smoot…
View article: Cancer cell – Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma
Cancer cell – Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma Open
View article: Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes macrophage recruitment in squamous cell carcinoma
Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes macrophage recruitment in squamous cell carcinoma Open
Summary Interactions between cells in the tumor microenvironment (TME) shape cancer progression and patient outcomes. To gain new insights into how the TME influences cancer outcomes, we derive gene expression signatures indicative of sign…
View article: PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State
PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State Open
Small 2022, 18, 2106097 DOI: 10.1002/smll.202106097 In the originally published article, some Acknowledgements were missing. The following text should be added: Acknowledgement to the IFOM flow cytometry facility, imaging facility, electro…
View article: 1678P The interaction between cancer cells and cancer-associated fibroblasts promotes RAS signalling in squamous cell carcinoma, resulting in an immune-suppressive tumour microenvironment and poorer survival outcomes
1678P The interaction between cancer cells and cancer-associated fibroblasts promotes RAS signalling in squamous cell carcinoma, resulting in an immune-suppressive tumour microenvironment and poorer survival outcomes Open
View article: PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State
PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State Open
Circulating tumor cell (CTC) clusters are associated with increased metastatic potential and worse patient prognosis, but are rare, difficult to count, and poorly characterized biophysically. The PillarX device described here is a bimodula…
View article: miR-146 connects stem cell identity with metabolism and pharmacological resistance in breast cancer
miR-146 connects stem cell identity with metabolism and pharmacological resistance in breast cancer Open
Although ectopic overexpression of miRNAs can influence mammary normal and cancer stem cells (SCs/CSCs), their physiological relevance remains uncertain. Here, we show that miR-146 is relevant for SC/CSC activity. MiR-146a/b expression is …
View article: Specialised endocytic proteins regulate diverse internalisation mechanisms and signalling outputs in physiology and cancer
Specialised endocytic proteins regulate diverse internalisation mechanisms and signalling outputs in physiology and cancer Open
Although endocytosis was first described as the process mediating macromolecule or nutrient uptake through the plasma membrane, it is now recognised as a critical component of the cellular infrastructure involved in numerous processes, ran…
View article: USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics
USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics Open
Deregulated epidermal growth factor receptor (EGFR) signaling is a key feature in different stages of oncogenesis. One important mechanism whereby cancer cells achieve increased and uncontrolled EGFR signaling is escaping down-modulation o…
View article: A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior
A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior Open
The subversion of endocytic routes leads to malignant transformation and has been implicated in human cancers. However, there is scarce evidence for genetic alterations of endocytic proteins as causative in high incidence human cancers. He…
View article: Case fatality rate analysis of Italian COVID‐19 outbreak
Case fatality rate analysis of Italian COVID‐19 outbreak Open
The Italian outbreak of COVID‐19 cases is a public health emergency and there is a worldwide tremendous interest in the evaluation of the Italian epidemic evolution. Indeed, from February 2020, Italy is facing an explosion of COVID‐19 case…
View article: CHARACTERIZATION OF EPSIN3 FUNCTION IN THE ACQUISITION OF A PARTIAL EMT STATE IN BREAST CANCER THROUGH E-CADHERIN ENDOCYTOSIS
CHARACTERIZATION OF EPSIN3 FUNCTION IN THE ACQUISITION OF A PARTIAL EMT STATE IN BREAST CANCER THROUGH E-CADHERIN ENDOCYTOSIS Open
Epsin3 (EPN3) belongs to the Epsin family of endocytic adaptors, which in humans comprises 3 members: Epsin1 (EPN1), Epsin2 (EPN2) and EPN3. Differently from the other members, EPN3 is expressed at very low levels in almost all tissues and…
View article: Alla ricerca di un modello di avvicinamento degli allievi della scuola primaria alla storia locale. Considerazioni e interrogativi
Alla ricerca di un modello di avvicinamento degli allievi della scuola primaria alla storia locale. Considerazioni e interrogativi Open
Following is told is a life journey that has hoarded a process and produced a totally new archive. Giangreco presents his life experience which led him from a technical restorer to a public historian for passion. A rich bibliography relati…
View article: ENABLE 2017, the First European PhD and Post-Doc Symposium. Session 2: The OMICS Revolution
ENABLE 2017, the First European PhD and Post-Doc Symposium. Session 2: The OMICS Revolution Open
The European Academy for Biomedical Science (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned European Research Institutes (Institute for Research in Biomedicine—IRB Barcelona, Spain; Radbo…
View article: ENABLE 2017, the First European PhD and Post-Doc Symposium. Session 1: Building the Foundations of Biology: Synthetic and Cellular Research
ENABLE 2017, the First European PhD and Post-Doc Symposium. Session 1: Building the Foundations of Biology: Synthetic and Cellular Research Open
The European Academy for Biomedical Science (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned European Research Institutes (Institute for Research in Biomedicine—IRB Barcelona, Spain; Radbo…
View article: ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 4: From Discovery to Cure: The Future of Therapeutics
ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 4: From Discovery to Cure: The Future of Therapeutics Open
The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned European Research Institutes (Institute for Research in Biomedicine—IRB Barcelona, Spain; Radbo…
View article: ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 3: In Vitro to In Vivo: Modeling Life in 3D
ENABLE 2017, the First EUROPEAN PhD and Post-Doc Symposium. Session 3: In Vitro to In Vivo: Modeling Life in 3D Open
The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned European research institutes (Institute for Research in Biomedicine—IRB Barcelona, Spain; Radbo…