Gianluca Ianiro
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View article: Biomarker-Associated Remission After Switching to Dupilumab in Severe Asthma Following Failure of Prior Biologics
Biomarker-Associated Remission After Switching to Dupilumab in Severe Asthma Following Failure of Prior Biologics Open
Background/Objectives: Severe asthma remains difficult to treat, even with the range of biologics we now have that target type 2 inflammation. Some patients do not respond well enough to the first biologic they try, which raises the questi…
View article: Biomarker-Associated Remission with Anti-IL-4R/IL-13 Therapy After Failure of Prior Biologics in Severe Asthma
Biomarker-Associated Remission with Anti-IL-4R/IL-13 Therapy After Failure of Prior Biologics in Severe Asthma Open
Background/Objectives Severe asthma remains difficult to treat, even with the range of biologics we now have that target type 2 inflammation. Some patients do not respond well enough to the first biologic they try, which raises the questio…
View article: DISYNCRO: Perceived roles of clinical study coordinators and data managers: results from a web-based survey of professionals from contract research organizations
DISYNCRO: Perceived roles of clinical study coordinators and data managers: results from a web-based survey of professionals from contract research organizations Open
View article: Autobrewery Syndrome and Endogenous Ethanol Production in Patients with MASLD: A Perspective from Chronic Liver Disease
Autobrewery Syndrome and Endogenous Ethanol Production in Patients with MASLD: A Perspective from Chronic Liver Disease Open
Autobrewery syndrome is a rare condition characterized by the endogenous fermentation of carbohydrates by gut microbiota, which exceeds the liver’s detoxification capacity and leads to signs and symptoms of acute alcohol intoxication. This…
View article: Intestinal inflammation and microbiota modulation impact cochlear function: emerging insights in gut-ear axis
Intestinal inflammation and microbiota modulation impact cochlear function: emerging insights in gut-ear axis Open
View article: Fecal Microbiome Transplantation for Recurrent CDI: Treatment Efficacy and Safety with Oral Capsules
Fecal Microbiome Transplantation for Recurrent CDI: Treatment Efficacy and Safety with Oral Capsules Open
Background and Aims: Fecal microbiota transplantation is an effective treatment method for recurrent Clostridioides difficile infection. Widely used enteric tube and colonoscopy methods demonstrate excellent efficacy and safety results. Re…
View article: The Multi-Faceted Role of Gut Microbiota in Alopecia Areata
The Multi-Faceted Role of Gut Microbiota in Alopecia Areata Open
Alopecia areata (AA) is a complex autoimmune disorder with multifactorial pathogenesis. Recent research highlights the gut microbiota as a possible key player in AA pathogenesis through the gut–skin axis: gut dysbiosis may disrupt intestin…
View article: Cancer Vaccines: A Promising Therapeutic Strategy in Advanced Solid Tumors
Cancer Vaccines: A Promising Therapeutic Strategy in Advanced Solid Tumors Open
Recent advancements in understanding how cancer cells evade immune recognition have led to significant progress in cancer immunotherapy. Therapeutic cancer vaccines hold great promise due to their safety, specificity, and ability to establ…
View article: Letter: <scp><i>Helicobacter pylori</i></scp> and Eosinophilic Oesophagitis—Lost in Definition? Authors' Reply
Letter: <span><i>Helicobacter pylori</i></span> and Eosinophilic Oesophagitis—Lost in Definition? Authors' Reply Open
View article: Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial
Multistrain Probiotics Plus Vitamin D Improve Gut Barrier Function and Gut Microbiota Composition in Irritable Bowel Syndrome Without Constipation: Results from a Double-Blind, Randomized, Placebo-Controlled Trial Open
Background: The disruption of the intestinal barrier and the imbalance of the gut microbiota (GM) seem to play a major role in the complex pathogenesis of irritable bowel syndrome (IBS). Specific microbial strains could improve the gut mic…
View article: The microbiome for clinicians
The microbiome for clinicians Open
Despite promising evidence in diagnostics and therapeutics, microbiome research is not yet implemented into clinical medicine. Several initiatives, including the standardization of microbiome research, the refinement of microbiome clinical…
View article: <i>Clostridioides difficile</i>: Treating Sustained Antibiotic Responders With Fecal Microbiota Transplantation Does Not Improve Efficacy
<i>Clostridioides difficile</i>: Treating Sustained Antibiotic Responders With Fecal Microbiota Transplantation Does Not Improve Efficacy Open
To the Editor—Drekonja et al [1] describe a randomized placebo-controlled trial with lyophilized fecal microbiota transplantation (FMT) capsules to prevent recurrent Clostridioides difficile infection (rCDI). We believe the results should …
View article: Letter: Meta‐Analysis Critique: Refining the Association Between <i>Helicobacter pylori</i> and Eosinophilic Oesophagitis. Authors' Reply
Letter: Meta‐Analysis Critique: Refining the Association Between <i>Helicobacter pylori</i> and Eosinophilic Oesophagitis. Authors' Reply Open
View article: Preferred Reporting Items for Microbiotherapy (PRIM) Guidelines Across Medical Disciplines: An International Delphi Consensus
Preferred Reporting Items for Microbiotherapy (PRIM) Guidelines Across Medical Disciplines: An International Delphi Consensus Open
Microbiotherapy has opened new avenues for managing dysbiosis‐related diseases. However, many studies did not cover all the necessary reporting items for microbiotherapy making the interpretation of results, safety assessment, technology e…
View article: Letter: Disappearing Microbe, Emerging Disease? Nuancing the Protective Effects of <i>Helicobacter pylori</i> Against Eosinophilic Oesophagitis. Authors' Reply
Letter: Disappearing Microbe, Emerging Disease? Nuancing the Protective Effects of <i>Helicobacter pylori</i> Against Eosinophilic Oesophagitis. Authors' Reply Open
View article: Machine Learning and Artificial Intelligence in the Multi-Omics Approach to Gut Microbiota
Machine Learning and Artificial Intelligence in the Multi-Omics Approach to Gut Microbiota Open
The gut microbiome is involved in human health and disease, and its comprehensive understanding is necessary to exploit it as a diagnostic or therapeutic tool. Multi-omics approaches, including metagenomics, metatranscriptomics, metabolomi…
View article: From big data and experimental models to clinical trials: Iterative strategies in microbiome research
From big data and experimental models to clinical trials: Iterative strategies in microbiome research Open
Microbiome research has expanded significantly in the last two decades, yet translating findings into clinical applications remains challenging. This perspective discusses the persistent issue of correlational studies in microbiome researc…
View article: The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier
The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier Open
Ultra-processed foods (UPFs) have become a widely consumed food category in modern diets. However, their impact on gut health is raising increasing concerns. This review investigates how UPFs impact the gut microbiome and gut barrier, emph…
View article: Meta‐Analysis: Inverse Association Between <scp><i>Helicobacter pylori</i></scp> Infection and Eosinophilic Oesophagitis
Meta‐Analysis: Inverse Association Between <span><i>Helicobacter pylori</i></span> Infection and Eosinophilic Oesophagitis Open
Background Exposure to Helicobacter pylori ( H. pylori ) has been associated with a decreased risk of eosinophilic oesophagitis (EoE). Aim The aim of this study is to determine the association between H. pylori infection and EoE in this up…
View article: Guidance for Fecal Microbiota Transplantation Trials in Ulcerative Colitis: The Second ROME Consensus Conference
Guidance for Fecal Microbiota Transplantation Trials in Ulcerative Colitis: The Second ROME Consensus Conference Open
Background Fecal microbiota transplantation (FMT) is emerging as a potential treatment modality for individuals living with inflammatory bowel disease (IBD). Despite its promise, the effectiveness of FMT for treating IBD, particularly for …
View article: Fecal microbiota transplantation: transitioning from chaos and controversial realm to scientific precision era
Fecal microbiota transplantation: transitioning from chaos and controversial realm to scientific precision era Open
With the popularization of modern lifestyles, the spectrum of intestinal diseases has become increasingly diverse, presenting significant challenges in its management. Traditional pharmaceutical interventions have struggled to keep pace wi…
View article: International consensus statement on microbiome testing in clinical practice
International consensus statement on microbiome testing in clinical practice Open
View article: “Pleiotropic” Effects of Antibiotics: New Modulators in Human Diseases
“Pleiotropic” Effects of Antibiotics: New Modulators in Human Diseases Open
Antibiotics, widely used medications that have significantly increased life expectancy, possess a broad range of effects beyond their primary antibacterial activity. While some are recognized as adverse events, others have demonstrated une…
View article: Review Article: Green Management of <scp>IBD</scp>—New Paradigms for an Eco‐Friendly Approach
Review Article: Green Management of <span>IBD</span>—New Paradigms for an Eco‐Friendly Approach Open
Background The worldwide prevalence of inflammatory bowel disease (IBD) is increasing, with its potential evolution as a global disease and a consequent increase in its burden on healthcare systems. These estimates do not factor in the ‘re…
View article: The importance of gut microbiome in the perinatal period
The importance of gut microbiome in the perinatal period Open
This narrative review describes the settlement of the neonatal microbiome during the perinatal period and its importance on human health in the long term. Delivery methods, maternal diet, antibiotic exposure, feeding practices, and early i…
View article: The role of microbiome in the development of gluten-related disorders
The role of microbiome in the development of gluten-related disorders Open
Gluten-related disorders (GRD) include celiac disease (CD), non celiac gluten sensitivity (NCGS) and wheat allergy (WA), conditions that are associated with the ingestion of gluten-containing food. Gut microbiota composition and function m…
View article: Gut microbiota in colorectal cancer: From pathogenesis to clinic
Gut microbiota in colorectal cancer: From pathogenesis to clinic Open
Colorectal cancer is the third most common type of cancer, with a significant burden on healthcare and social systems. Its incidence is constantly rising, due to the spread of unhealthy lifestyle, i.e. Western diet. Increasing evidence sug…
View article: A 1-year follow-up study on checkpoint inhibitor-induced colitis: results from a European consortium
A 1-year follow-up study on checkpoint inhibitor-induced colitis: results from a European consortium Open
Patients with IBD-like colitis may need an early and more aggressive treatment. Future studies should focus on how to improve long-term clinical outcomes.
View article: Lynch Syndrome and Thyroid Nodules: A Single Center Experience
Lynch Syndrome and Thyroid Nodules: A Single Center Experience Open
Background: Lynch syndrome (LS) is a genetic disease with increased risk of colorectal cancer and other malignancies. There are few reported cases of thyroid cancer in LS patients. The aim of this study is to investigate the presence of th…
View article: Helicobacter pylori and the Human Gastrointestinal Microbiota: A Multifaceted Relationship
Helicobacter pylori and the Human Gastrointestinal Microbiota: A Multifaceted Relationship Open
Helicobacter pylori is a type of Gram-negative bacteria belonging to the Proteobacteria phylum which is known to cause gastrointestinal disorders such as gastritis and gastric ulcers. Its treatment is based on current eradication regimens,…